The DOI matches its Crossref record.
Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics
Abstract
The aims of this research were (a) to compare food restriction initiated in adult life of male Fischer 344 rats with that limited to early life or involving most of the life span on physical, metabolic, and longevity characteristics and (b) to study a similar level of protein restriction without caloric restriction on these characteristics. Food restriction (60% of the ad libitum intake) initiated at 6 months of age markedly increased life span as did a similar restriction started at 6 weeks of age, but food restriction limited to early life (6 weeks to 6 months of age) and protein restriction caused only a small increase in longevity. Food restriction does not act by reducing the intake of calories or other nutrient per gram of body mass, a finding not in accord with classic views. A progressive decrease in spontaneous locomotive activity with age occurred in ad libitum fed but not restricted rats.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Overview of caloric restriction and ageing
Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 879
Self-citationTranscriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16
McElwee, J., Bubb, K., & Thomas, J. H. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00043.x · Cited by 416
Methionine restriction increases blood glutathione and longevity in F344 rats
Richie, J. P., Leutzinger, Y., Parthasarathy, S., Maixoy, V., Orentreich, N., & Zimmerman, J. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.15.8001743 · Cited by 363
Molecular mechanisms linking calorie restriction and longevity
Merry, B. J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00038-9 · Cited by 304
Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., & Cider, N. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90107-q · Cited by 279
Metadata
- Authors
- Yu, B. P., Masoro, E. J., & McMahan, C. A.
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-11-01
- Volume
- 40
- Issue
- 6
- Pages
- 657-670
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W1965217275
- Cited by
- 591
- References
- 0
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics. https://app.cochat.ai/papers/10.1093/geronj/40.6.657
- The paper
- Yu, B. P., Masoro, E. J., & McMahan, C. A. (1985). Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics. Journal of Gerontology. https://doi.org/10.1093/geronj/40.6.657
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
