Methionine restriction increases blood glutathione and longevity in F344 rats

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

Tietze, F. (1969) · Analytical Biochemistry · doi:10.1016/0003-2697(69)90064-5 · Cited by 6,077 · see citing works

Glutathione metabolism and its selective modification.

Meister, A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77815-6 · Cited by 2,012 · see citing works

A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids

Gaitonde, M. (1967) · Biochemical Journal · doi:10.1042/bj1040627 · Cited by 1,235 · see citing works

Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

Yu, B., Masoro, E. J., & McMahan, C. A. (1985) · Journal of Gerontology · doi:10.1093/geronj/40.6.657 · Cited by 591 · see citing works

Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine.

Kalebic, T., Kinter, A. L., Poli, G., Anderson, M. E., Meister, A., & Fauci, A. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.986 · Cited by 324 · see citing works

Free and protein-bound glutathione in normal and cataractous human lenses

Harding, J. J. (1970) · Biochemical Journal · doi:10.1042/bj1170957 · Cited by 290 · see citing works

Glutathione contents of tissues in the aging mouse

Hazelton, G. A., & Lang, C. A. (1980) · Biochemical Journal · doi:10.1042/bj1880025 · Cited by 268 · see citing works

Influence of diet on survival of mice.

Fernandes, G., Yunis, E. J., & Good, R. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1279 · Cited by 264 · see citing works

Hepatic Glutathione Homeostasis in the Rat: Efflux Accounts for Glutathione Turnover

Lauterburg, B. H., Adams, J. D., Jr., & Mitchell, J. R. (1984) · Hepatology · doi:10.1002/hep.1840040402 · Cited by 261 · see citing works

Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus

Murakami, K., Kondo, T., Ohtsuka, Y., et al. (1989) · Metabolism · doi:10.1016/0026-0495(89)90061-9 · Cited by 251 · see citing works

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

Youngman, L. D., Park, J. Y., & Ames, B. N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9112 · Cited by 250 · see citing works

Low blood glutathione levels in healthy aging adults.

Lang, C. A., Naryshkin, S., Schneider, D. L., Mills, B. J., & Lindeman, R. D. (1992) · PubMed · Cited by 213 · see citing works

Influence of mouse age and erythrocyte age on glutathione metabolism

Abraham, E. C., Taylor, J. F., & Lang, C. A. (1978) · Biochemical Journal · doi:10.1042/bj1740819 · Cited by 114 · see citing works

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

Chen, T. S., Richie, J. P., & Lang, C. A. (1989) · Experimental Biology and Medicine · doi:10.3181/00379727-190-42879 · Cited by 110 · see citing works

Life span profiles of glutathione and acetaminophen detoxification.

Chen, T. S., Richie, J. P., & Lang, C. A. (1990) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08686-6 · Cited by 101 · see citing works

Severe depletion in liver glutathione during physical exercise

Pyke, S., Lew, H., & Quintanilha, A. T. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80266-2 · Cited by 77 · see citing works

The role of glutathione in aging and cancer

Richie, J. P. (1992) · Experimental Gerontology · doi:10.1016/0531-5565(92)90015-r · Cited by 77 · see citing works

Age-related cysteine uptake as rate-limiting in glutathione synthesis and glutathione half-life in the cultured human lens

Rathbun, W. B., & Murray, D. L. (1991) · Experimental Eye Research · doi:10.1016/0014-4835(91)90075-p · Cited by 73 · see citing works

Effect of age on oxygen consumption, superoxide dismutase, catalase, glutathione, inorganic peroxides and chloroform-soluble antioxidants in the adult male housefly, Musca domestica

Sohal, R. S., Farmer, K. J., Allen, R. G., & Cohen, N. R. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90070-8 · Cited by 67 · see citing works

Calorie Source, Calorie Restriction, Immunity and Aging of (NZB/NZW)F1 Mice

Kubo, C., Johnson, B. C., Day, N. K. B., & Good, R. A. (1984) · Journal of Nutrition · doi:10.1093/jn/114.10.1884 · Cited by 66 · see citing works

Tissue Glutathione as a Cyst(e)ine Reservoir during Cystine Depletion in Growing Rats

Cho, E. S., Johnson, N. J., & Snider, B. C. F. (1984) · Journal of Nutrition · doi:10.1093/jn/114.10.1853 · Cited by 64 · see citing works

Glutathione levels in hepatic and extrahepatic tissues of mice as a function of age

STOHS, S. J., Hassing, J. M., Al-Turk, W. A., et al. (1980) · AGE · doi:10.1007/bf02435000 · Cited by 55 · see citing works

Thiazolidine-4-carboxylic acid, a physiologic sulfhydryl antioxidant with potential value in geriatric medicine

Weber, H. U., Fleming, J. F., & Miquel, J. (1982) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(82)90030-9 · Cited by 55 · see citing works

Age-related changes of glutathione content, glutathione reductase and glutathione peroxidase activity of human erythrocytes.

Matsubara, L. S., & Machado, P. E. (1991) · PubMed · Cited by 54 · see citing works

Renal and hepatic output of glutathione in plasma and whole blood

Dass, P. D., Bermes, E. W., & HOLMES, E. W. (1992) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(92)90102-z · Cited by 53 · see citing works

Correction of a Glutathione Deficiency in the Aging Mosquito Increases Its Longevity

Richie, J. P., Mills, B. J., & Lang, C. A. (1987) · Experimental Biology and Medicine · doi:10.3181/00379727-184-42454 · Cited by 49 · see citing works

Some biochemical parameters of ageing in relation to dietary protein

De, A. K., Chipalkatti, S., & Aiyar, A. S. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90014-3 · Cited by 45 · see citing works

Glutathione Levels during the Mosquito Life Span with Emphasis on Senescence

Hazelton, G. A., & Lang, C. A. (1984) · Experimental Biology and Medicine · doi:10.3181/00379727-176-41867 · Cited by 44 · see citing works

Effects of Variation in the Dietary Supply of Cysteine and Methionine on Liver Concentration of Glutathione and “Active Sulfate” (PAPS) and Serum Levels of Sulfate, Cystine, Methionine and Taurine: Relation to the Metabolism of Acetaminophen

Glazenburg, E. J., Jekel-Halsema, I. M. C., Scholtens, E., et al. (1983) · Journal of Nutrition · doi:10.1093/jn/113.7.1363 · Cited by 38 · see citing works

Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age

Al-Turk, W. A., STOHS, S. J., El-Rashidy, F. H., et al. (1987) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1987.tb07154.x · Cited by 33 · see citing works

The effect of low protein-high dextrin diet and subsequent food restriction upon life prolongation in Fischer 344 male rats

Horáková, M., Deyl, Z., Hausmann, J., & Macek, K. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90014-0 · Cited by 29 · see citing works

Blood glutathione: a biochemical index of life span enhancement in the diet restricted Lobund-Wistar rat.

LANG, C. A., Wu, W. K., Chen, T., & Bj, M. (1989) · PubMed · Cited by 23 · see citing works

THE EFFECT OF DIET ON THE GLUTATHIONE CONTENT OF ERYTHROCYTES

Mortensen, R. A. (1953) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66133-2 · Cited by 22 · see citing works

A Decrease in Cysteine Levels Causes the Glutathione Deficiency of Aging in the Mosquito

Richie, J. P., & Lang, C. A. (1988) · Experimental Biology and Medicine · doi:10.3181/00379727-187-42660 · Cited by 20 · see citing works

Effect of sulfhydryl-deficient diets on hepatic metallothionein, glutathione, and adenosine 3′-phosphate 5′-phosphosulfate (PAPS) levels in rats

Sendelbach, L. E., White, C. A., Howell, S. R., Gregus, Z., & Klaassen, C. D. (1990) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(90)90025-p · Cited by 17 · see citing works

Radical-free biology of oxidative stress

Jones, D. P. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00283.2008 · Cited by 1,213 · see citing works

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534 · see citing works

Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts

Barja, G. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5148 · Cited by 290 · see citing works

MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism

Lee, C., Kim, K. H., & Cohen, P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.015 · Cited by 178 · see citing works

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., Khaitovich, P., Clish, C. B., Miller, R. A., & Gladyshev, V. N. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.018 · Cited by 167 · see citing works

Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats

Perrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N. (2010) · Metabolism · doi:10.1016/j.metabol.2009.10.023 · Cited by 136 · see citing works

FGF21 mediates the thermogenic and insulin-sensitizing effects of dietary methionine restriction but not its effects on hepatic lipid metabolism

Wanders, D., Forney, L. A., Stone, K. P., Burk, D. H., Pierse, A., & Gettys, T. W. (2017) · Diabetes · doi:10.2337/db16-1212 · Cited by 137 · see citing works

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00451-9 · Cited by 134 · see citing works

Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

Speakman, J. R., Mitchell, S. E., & Mazidi, M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.03.011 · Cited by 131 · see citing works

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

Lionaki, E., Ploumi, C., & Tavernarakis, N. (2022) · Cells · doi:10.3390/cells11020214 · Cited by 110 · see citing works

Cutting back on the essentials: can manipulating intake of specific amino acids modulate health and lifespan

Brown-Borg, H. M., & Buffenstein, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.007 · Cited by 70 · see citing works

The Antisteatotic and Hypolipidemic Effect of Insect Meal in Obese Zucker Rats is Accompanied by Profound Changes in Hepatic Phospholipid and 1-Carbon Metabolism

Meyer, S., Gessner, D. K., Wen, G., Most, E., Liebisch, G., Zorn, H., Ringseis, R., & Eder, K. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801305 · Cited by 23 · see citing works

Modification of tight junction structure and permeability by nutritional means

Mullin, J. M., Skrovanek, S. M., & Valenzano, M. C. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04028.x · Cited by 21 · see citing works

Supplementation of Sulfur-Containing Amino Acids or Essential Amino Acids Does Not Reverse the Hepatic Lipid-Lowering Effect of a Protein-Rich Insect Meal in Obese Zucker Rats

Meyer, S., Schäfer, L., Röhrig, J., Maheshwari, G., Most, E., Zorn, H., Ringseis, R., Eder, K., & Gessner, D. K. (2020) · Nutrients · doi:10.3390/nu12040987 · Cited by 5 · see citing works

Simple Structural Requirements for Sequence-Selective Peptide Receptors? Tripeptide Binding by a Podand Ionophore

Burger, M. T., & Still, W. C. (1997) · The Journal of Organic Chemistry · doi:10.1021/jo970256w · Cited by 14 · see citing works

Copper Tripeptides

Anastassakis, K. (2022) · Springer eBooks · doi:10.1007/978-3-031-08057-9_22

Synthesis of the tripeptide L-Trp-L-Ser-L-Glu. Comparison of its biological activity with that of the delta-sleep-inducing-peptide (DSIP).

Monnier, V. M. (1977) · PubMed · Cited by 5 · see citing works

Systemic screening of milk protein-derived ACE inhibitors through a chemically synthesised tripeptide library

Ren, F., Zhang, S., Guo, H., et al. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.03.108 · Cited by 10 · see citing works

Synthesis of the ‘southern’ tripeptide of Cyclomarins A and C having novel anti-tuberculocidal mode of action

Sathish, K., Reddy, G. P., Mainkar, P. S., et al. (2011) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2011.08.026 · Cited by 6 · see citing works