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Nutritional Influences on Aging of Fischer 344 Rats: II. Pathology
Abstract
The aim of this study was to explore the effects of nutritional manipulations on the occurrence and progression of age-related pathologic lesions in male Fischer 344 rats. The following nutritional regimens were studied: (a) ad libitum feeding, (b) food restriction initiated at 6 weeks of age, (c) food restriction initiated at 6 months of age, (d) food restriction limited to a period of early life (6 weeks to 6 months of age), (e) protein restriction without caloric restriction. The major age-related lesions observed were chronic nephropathy, cardiomyopathy, and neoplasia. Food restriction initiated at 6 months of age was as effective as food restriction initiated at 6 weeks of age in slowing the progression of chronic nephropathy and cardiomyopathy and in delaying the occurrence of neoplasia. Food restriction limited to early life was much less effective. Protein restriction in the absence of caloric restriction did not delay the occurrence of neoplasia, but it did retard chronic nephropathy and cardiomyopathy, although much less effectively than caloric restriction involving a similar level of protein restriction.
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Citations
Cited by
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245
Weindruch, R., Walford, R. L., Fligiel, S., & Guthrie, D. (1986) · The Journal of Nutrition · doi:10.1093/jn/116.4.641 · Cited by 992
Overview of caloric restriction and ageing
Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 879
Self-citationVan Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734
WILLCOX, B. J., WILLCOX, D. C., TODORIKI, H., FUJIYOSHI, A., YANO, K., HE, Q., CURB, J. D., & SUZUKI, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.037 · Cited by 370
Metadata
- Authors
- Maeda, H., Gleiser, C. A., Masoro, E. J., Murata, I., McMahan, C. A., & Yu, B. P.
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-11-01
- Volume
- 40
- Issue
- 6
- Pages
- 671-688
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W1972361162
- Cited by
- 362
- References
- 0
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maeda, H., Gleiser, C. A., Masoro, E. J., Murata, I., McMahan, C. A., & Yu, B. P. (1985). Nutritional Influences on Aging of Fischer 344 Rats: II. Pathology. Journal of Gerontology. https://doi.org/10.1093/geronj/40.6.671
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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