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The Influence of Dietary Protein Source on Longevity and Age-Related Disease Processes of Fischer Rats
Abstract
The influence of replacing dietary casein with soy protein on longevity and age-related pathologic lesions of male Fischer 344 rats was investigated. Caloric intake and body weights were similar for rats on the two diets. Rats on the soy protein-containing diet had a median length of life of 844 days compared to 730 days for those on the casein-containing diet (p less than .002), and the ages of the 10th percentile survivors were 937 and 857 days, respectively (p less than .02). The progression of chronic nephropathy was markedly retarded by replacing casein with soy protein. Only 7% of the rats dying spontaneously on the soy protein-containing diet exhibited end-stage chronic nephropathy compared to 41% of the rats on the casein-containing diet. Clearly, the soy protein-containing diet enables ad libitum fed male Fischer 344 rats to be used as a model for aging research without the occurrence of renal failure as a major confounding problem.
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Cited by
KDOQI clinical practice guideline for nutrition in CKD: 2020 update
Ikizler, T. A., Burrowes, J. D., Byham-Gray, L. D., Campbell, K. L., Carrero, J.-J., Chan, W., Fouque, D., Friedman, A. N., Ghaddar, S., Goldstein-Fuchs, D. J., et al. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.05.006 · Cited by 1,960
Weindruch, R., & Sohal, R. S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710023371407 · Cited by 743
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
Mair, W., Piper, M. D. W., & Partridge, L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030223 · Cited by 522
Aging and oxidative stress: Modulation by dietary restriction
Yu, B. P. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00162-1 · Cited by 443
Self-citationStrategies for Reducing or Preventing the Generation of Oxidative Stress
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Metadata
- Authors
- Iwasaki, K., Gleiser, C. A., Masoro, E. J., McMahan, C. A., Seo, E.-J., & Yu, B. P.
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-01-01
- Volume
- 43
- Issue
- 1
- Pages
- B5-B12
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W2034094218
- Cited by
- 224
- References
- 0
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Influence of Dietary Protein Source on Longevity and Age-Related Disease Processes of Fischer Rats. https://app.cochat.ai/papers/10.1093/geronj/43.1.b5
- The paper
- Iwasaki, K., Gleiser, C. A., Masoro, E. J., McMahan, C. A., Seo, E.-J., & Yu, B. P. (1988). The Influence of Dietary Protein Source on Longevity and Age-Related Disease Processes of Fischer Rats. Journal of Gerontology. https://doi.org/10.1093/geronj/43.1.b5
Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
