The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
Strategies for Reducing or Preventing the Generation of Oxidative Stress
Open accessAbstract
The reduction of oxidative stress could be achieved in three levels: by lowering exposure to environmental pollutants with oxidizing properties, by increasing levels of endogenous and exogenous antioxidants, or by lowering the generation of oxidative stress by stabilizing mitochondrial energy production and efficiency. Endogenous oxidative stress could be influenced in two ways: by prevention of ROS formation or by quenching of ROS with antioxidants. However, the results of epidemiological studies where people were treated with synthetic antioxidants are inconclusive and contradictory. Recent evidence suggests that antioxidant supplements (although highly recommended by the pharmaceutical industry and taken by many individuals) do not offer sufficient protection against oxidative stress, oxidative damage or increase the lifespan. The key to the future success of decreasing oxidative-stress-induced damage should thus be the suppression of oxidative damage without disrupting the wellintegrated antioxidant defense network. Approach to neutralize free radicals with antioxidants should be changed into prevention of free radical formation. Thus, this paper addresses oxidative stress and strategies to reduce it with the focus on nutritional and psychosocial interventions of oxidative stress prevention, that is, methods to stabilize mitochondria structure and energy efficiency, or approaches which would increase endogenous antioxidative protection and repair systems.
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Cited by
Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants
Poljsak, B., Šuput, D., & Milisav, I. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/956792 · Cited by 1,301
Self-citationRegulation of Pichia pastoris promoters and its consequences for protein production
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Jamwal, S., Blackburn, J. K., & Elsworth, J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107705 · Cited by 236
The neglected significance of “antioxidative stress”
Poljsak, B., & Milisav, I. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/480895 · Cited by 177
Coles, L. D., Tuite, P. J., Öz, G., Mishra, U. R., Kartha, R. V., Sullivan, K. M., Cloyd, J. C., & Terpstra, M. (2018) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.1008 · Cited by 170
Metadata
- Authors
- Poljsak, B.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-15
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2101108369
- Cited by
- 286
- References
- 190
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
