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Three Mutants That Extend Both Mean and Maximum Life Span of the Nematode, Caenorhabditis Elegans, Define the Age-1 Gene
Abstract
Long-lived mutants in the nematode Caenorhabditis elegans have been studied to determine if the mutations responsible for extended life were allelic. Three of four mutant strains studied (MK31, MK542, MK546) contain recessive mutations that significantly lengthen life; MK542 and MK546 consistently fail to complement the long life phenotype of age-1 and are therefore allelic. MK31, although longer lived than wild type, is equivocal, in some cases failing to complement age-1 but not in others. All three long-lived strains have reduced hermaphrodite self-fertility and also fail to complement for this presumed pleiotropic effect of the age-1 mutation. Each of these three strains also contains an independent mutation at unc-31 IV. Since the mutants were isolated in the same mutant hunt (Klass, 1983) using protocols that did not guarantee independence, the mutations cannot be assumed to be independently isolated.
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“The lifespan and healthspan of invertebrates are extended by mutations in pathways such as the DAF-2, a gene that encodes for the IGF-1 pathway in the nematode Caenorhabditis elegans (C. elegans), or the mTOR signaling pathways that are linked to accelerating the aging process (60, 62–65).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [62]
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Metadata
- Authors
- Friedman, D. B., & Johnson, T. E.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Johnson, T. E.
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-07-01
- Volume
- 43
- Issue
- 4
- Pages
- B102-B109
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W1491447916
- Cited by
- 240
- References
- 0
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 11 · 2017: 4 · 2016: 15 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Science of Aging Knowledge Environment
- Funders
- National Science Foundation
- National Institute on Aging (AG05720, N01-AG-92113)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Nematode management and characterization studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Caenorhabditis elegans, long-lived mutants, lifespan extension, allelic complementation, recessive mutations, self-fertility, unc-31, pleiotropy, aging
- MeSH terms
- Aging, Alleles, Animals, Caenorhabditis, Crosses, Genetic, Fertility, Genes, Genetic Complementation Test, Longevity, Male, Mutation, Phenotype, Disorders of Sex Development
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