Influenza virus infection and bacterial clearance in young adult and aged mice.
Abstract
The effects of influenza A/Hong Kong/68 (H3N2) virus infection on clearance of bacteria (Staphylococcus aureus or Serratia marcescens) from lungs of young adult (8-week-old) and aged (2-year-old) CBA/2N mice were studied. No consistent differences in pulmonary bacterial clearance were observed in uninfected animals of either age group. However, both young and aged virus-infected mice consistently exhibited significantly reduced ability to clear challenge bacteria from their lungs compared to age-matched nonvirus-infected controls; this deficit was markedly more pronounced in virus-infected aged mice. The extra deficit seen in virus-infected aged animals did not correlate with pulmonary virus or interferon titers, or with severity of pulmonary histopathology. Moreover, the phagocytic and bactericidal activities of pulmonary macrophages and polymorphonuclear neutrophiles from virus-infected young and aged mice were comparable.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In animal models, influenza infection increases and prolongs bacterial growth due to reduced macrophage accumulation and decreased bacterial clearance from reduced phagocytic activity.
“Many studies involving animal models have shown that influenza infection increases and prolongs bacterial growth, due to reduced macrophage accumulation and decreased bacterial clearance due to reduced phagocytic activity (Kleinerman et al., 1976; Wyde et al., 1989; Sun and Metzger, 2008).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Wyde et al., 1989
Cited by
Sorted by citations
Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat
Zetola, N., Francis, J. S., Nuermberger, E. L., & Bishai, W. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70112-2 · Cited by 791 · see citing works
Secondary bacterial infections associated with influenza pandemics
Morris, D. E., Cleary, D. W., & Clarke, S. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01041 · Cited by 576 · see citing works
“Many studies involving animal models have shown that influenza infection increases and prolongs bacterial growth, due to reduced macrophage accumulation and decreased bacterial clearance due to reduced phagocytic activity (Kleinerman et al., 1976; Wyde et al., 1989; Sun and Metzger, 2008).”
BackgroundAge-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection
Po, J. L., Gardner, E. M., Anaraki, F., Katsikis, P. D., & Murasko, D. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00010-6 · Cited by 143 · see citing works
“associated with prolonged virus shedding in the lung (Bender et al., 1995; Wyde et al., 1989; Bender et al., 1991).”
BackgroundA Mouse Model of Lethal Synergism Between Influenza Virus and Haemophilus influenzae
Lee, L. N., Dias, P. B., Han, D., Yoon, S., Shea, A., Zakharov, V., Parham, D. M., & Sarawar, S. R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090596 · Cited by 69 · see citing works
Approaches to the Identification and Recording of Nasal Lesions in Toxicology Studies
Morgan, K. T. (1991) · Toxicologic Pathology · doi:10.1177/0192623391019004-103 · Cited by 66 · see citing works
Effect of Age on Respiratory Defense Mechanisms
Antonini, J. M., Roberts, J. R., Clarke, R. W., Yang, H.-M., Barger, M. W., Ma, J. Y. C., & Weissman, D. N. (2001) · CHEST Journal · doi:10.1378/chest.120.1.240 · Cited by 50 · see citing works
Heterotypic Immune Mice Lose Protection against Influenza Virus Infection with Senescence
Bender, B. S., & Small, P. A. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/168.4.873 · Cited by 44 · see citing works
“[22], however, demonstrated that both young and aged influenza-infected mice had reduced clearance of bacteria from”
BackgroundVitamin E and infectious diseases in the aged
Han, S. N., & Meydani, S. N. (1999) · Proceedings of The Nutrition Society · doi:10.1017/s0029665199000919 · Cited by 42 · see citing works
“The increased susceptibility to secondary bacterial invasion following influenza infection is attributed to decreased mucociliary clearance by the airways, enhanced bacterial adherence to influenza-infected cells, immunosuppression caused by virus infection, and decreased bacterial clearance by phagocytes (Rouse & Hor…”
BackgroundMethicillin-resistant Staphylococcus Aureus Infection
Bradley, S. (1992) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30449-x · Cited by 38 · see citing works
The effect of aging on immune responses
Fermaglich, D. H., & Horohov, D. W. (2002) · Veterinary Clinics of North America Equine Practice · doi:10.1016/s0749-0739(02)00027-5 · Cited by 27 · see citing works
“[12] Wyde PR, Six HR, Ambrose MW, et al.”
BackgroundThe role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats
Barrientos, R. M., Thompson, V. M., Arnold, T. H., Frank, M. G., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.004 · Cited by 8 · see citing works
Effects of respiratory viruses on pulmonary alveolar macrophages
Witten, M. L., Grad, R., Quan, S. F., et al. (1992) · Pediatric Pulmonology · doi:10.1002/ppul.1950120209 · Cited by 4 · see citing works
Renegar, K. B., Menge, A. C., & Mestecky, J. F. (2006) · Viral Immunology · doi:10.1089/vim.2006.19.613 · Cited by 2 · see citing works
The effect of aging on the immune response to vaccination in the horse
Fermaglich, D. H. (2003) · doi:10.31390/gradschool_theses.2499
“7 contrast, the phagocytic and bactericidal activities of pulmonary macrophages and neutrophils from young and aged mice appear comparable (39).”
Background
- Authors
- Wyde, P. R., Six, H. R., Ambrose, M. W., & Throop, B. J.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-09-01
- Volume
- 44
- Issue
- 5
- Pages
- B118-B124
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W2325783934
- Cited by
- 14
- References
- 0
- Citations by year
- 2017: 1 · 2014: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03ag005854-01)
- National Institute on Aging (R03 AG-05854)
- National Institute of Allergy and Infectious Diseases (AI-62517)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- influenza, bacterial clearance, Staphylococcus aureus, Serratia marcescens, aged mice, immunosenescence, lung macrophages, neutrophils, phagocytosis, pulmonary infection, interferon
- MeSH terms
- Aging, Animals, Bacteria, Interferons, Lung, Macrophages, Mice, Inbred CBA, Neutrophils, Orthomyxoviridae Infections, Influenza A virus, Phagocytosis, Serratia marcescens, Staphylococcus aureus, Culture Techniques, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
