Cited by 362Influenza Virus Research Studiesinterferon and immune responsesVirology and Viral Diseases

Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication

Open access
Bergmann, Michael, Garcia-Sastre, Adolfo, Carnero, Elena, Pehamberger, Hubert, Wolff, Klaus, Palese, Peter, Muster, Thomas·2000·Journal of Virology

Abstract

The availability of an influenza virus NS1 gene knockout virus (delNS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA-activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.

Integrity signals

Registry

Crossref · 10.1128/jvi.74.13.6203-6206.2000

Cites

38 of 38 references verified0 citation errors · 0 not checkable

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  • The influenza virus NS1 protein inhibits PKR activation, resulting in increased viral replication in the lung.

    “The influenza virus NS1 protein, for example, inhibits PKR activation, resulting in increased viral replication in the lung (20).”

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Authors
Bergmann, M., Garcia-Sastre, A., Carnero, E., Pehamberger, H., Wolff, K., Palese, P., & Muster, T.
Affiliations
  • <!--label omitted: 1-->Department of Surgery1and
  • <!--label omitted: 2-->Department of Microbiology, Mount Sinai Medical Center, New York, New York 100292
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Vienna (AT)
Venue
Journal of Virology
Published
2000-07
Volume
74
Issue
13
Pages
6203-6206
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2151778974
Cited by
362
References
38
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 13 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 18
FWCI
14.43
Type
journal article
Language
en
Open access
Locations
  • Journal of Virology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
PKR, double-stranded RNA-dependent protein kinase, antiviral response, viral replication, host-pathogen interaction, viral pathogenicity, interferon-stimulated genes
MeSH terms
Animals, Disease Models, Animal, DNA-Binding Proteins, Humans, Influenza, Human, Interferons, Lung, Mice, Inbred C57BL, Influenza A virus, Virus Replication, Trans-Activators, Viral Nonstructural Proteins, Mice, Knockout, eIF-2 Kinase, STAT1 Transcription Factor, Mice

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