Cited by 303T-cell and B-cell ImmunologyImmune responses and vaccinationsNutrition and Health in Aging

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Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60

Wayne, S. J., Rhyne, R. L., Garry, P. J., Goodwin, J. S.·1990·Journal of Gerontology

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Abstract

Previous studies have suggested an association between depressed cell-mediated immunity and increased mortality in elderly persons. However, the effects of age and existing disease on this association have not been adequately addressed. We studied the association between cell-mediated immunity and subsequent morbidity and mortality in 273 initially healthy persons 60 years of age and older. In 1979, two tests of cell-mediated immunity were conducted--mitogen stimulation with phytohaemagglutinin, and delayed hypersensitivity skin testing. The study group was followed annually for development of pneumonia, cancer, and death. Anergy was associated with all-cause mortality (hazard ratio of 2.16; 95% confidence interval [1.10,4.28]). When the results were adjusted for age, the resulting hazard ratio was 1.89;[0.94,3.79]. A relationship was also suggested between anergy and cancer mortality although this association was not statistically significant. Response to phytohaemagglutinin was a poorer predictor of mortality than was response to delayed hypersensitivity skin testing. The results show that anergy may be a good indicator of subsequent all-cause mortality, and perhaps cancer mortality, in elderly who lack other indicators of poor health.

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Effects of aging and long-term dietary restrictions on cholesterol metabolism in the rat forebrain
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Immune System
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Authors: Wayne, S. J., Rhyne, R. L., Garry, P. J., & Goodwin, J. S.
Affiliations: University of New Mexico (US)
ORCID: Goodwin, J. S.
Venue: Journal of Gerontology
Publisher: Oxford University Press (OUP)
Published: 1990-03-01
Volume: 45
Issue: 2
Pages: M45-M48
ISSN: 0022-1422 (ISSN-L)
DOI: 10.1093/geronj/45.2.m45
OpenAlex: W1993142368
Cited by: 303
References: 0
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 15
FWCI: 2.92
Type: journal article
Language: en
Open access: closed
Locations: Journal of Gerontology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag006086-04)
U.S. Public Health Service
National Institute on Aging (AG 02049, AG 06086)
National Center for Research Resources (RR 00997, M01RR000997)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: cell-mediated immunity, anergy, mortality prediction, morbidity, older adults, phytohemagglutinin, mitogen stimulation, pneumonia, cancer mortality, all-cause mortality, aging
MeSH terms: Aged, Aging, Female, Follow-Up Studies, Humans, Hypersensitivity, Delayed, Immunity, Cellular, Lymphocyte Activation, Male, Middle Aged, Mitogens, Morbidity, Mortality, Neoplasms, Phytohemagglutinins, Probability, Skin Tests, Cohort Studies, Survival Rate, Proportional Hazards Models

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Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60

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