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Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60
Abstract
Previous studies have suggested an association between depressed cell-mediated immunity and increased mortality in elderly persons. However, the effects of age and existing disease on this association have not been adequately addressed. We studied the association between cell-mediated immunity and subsequent morbidity and mortality in 273 initially healthy persons 60 years of age and older. In 1979, two tests of cell-mediated immunity were conducted--mitogen stimulation with phytohaemagglutinin, and delayed hypersensitivity skin testing. The study group was followed annually for development of pneumonia, cancer, and death. Anergy was associated with all-cause mortality (hazard ratio of 2.16; 95% confidence interval [1.10,4.28]). When the results were adjusted for age, the resulting hazard ratio was 1.89;[0.94,3.79]. A relationship was also suggested between anergy and cancer mortality although this association was not statistically significant. Response to phytohaemagglutinin was a poorer predictor of mortality than was response to delayed hypersensitivity skin testing. The results show that anergy may be a good indicator of subsequent all-cause mortality, and perhaps cancer mortality, in elderly who lack other indicators of poor health.
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“Early studies indicated that the magnitude of T cell proliferative responses to mitogens in vitro is positively associated with survival in the elderly (Roberts-Thomson et al. 1974; Wayne et al. 1990).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Wayne et al. 1990
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Self-citationPawelec, G., Sansom, D., Rehbein, A., Adibzadeh, M., & Beckman, I. (1996) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00097-6 · Cited by 68
Pekmezci, D. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386960-9.00008-3 · Cited by 70
“Recent studies also suggest that the status of the immune response could predict mortality in the elderly (RobertsThomson et al., 1974; Wayne et al., 1990) and animals (Nagel et al.,”
BackgroundDecreased Immunity and Increased Morbidity in the Elderly
Goodwin, J. S. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb01515.x · Cited by 67
Self-citationWaart, F. G. D., Portengen, L., Doekes, G., Verwaal, C. J., & Kok, F. J. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970193 · Cited by 67
CD4 memory T cell levels predict life span in genetically heterogeneous mice
Miller, R. A., Chrisp, C. E., & Gałecki, A. T. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.10.9271362 · Cited by 67
Micronutrients in women’s health and immune function
Bendich, A. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00649-9 · Cited by 65
Effect of Acupuncture Treatment on the Immune Function Impairment Found in Anxious Women
Arranz, L., Guayerbas, N., Siboni, L., & la Fuente, M. D. (2007) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x07004606 · Cited by 66
“In view of the above, the aim of the present work was to study, in adult anxious women, whether several immune functions, which have been described to be impaired in anxiety (Koh and Lee, 1996) and are good health markers (Wayne et al., 1990), can be restored to the levels of healthy women after an acupuncture treatme…”
BackgroundAlvarado, C., Álvarez, P., Jiménez, L., & la Fuente, M. D. (2006) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2006.03.004 · Cited by 63
The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women
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Metadata
- Authors
- Wayne, S. J., Rhyne, R. L., Garry, P. J., & Goodwin, J. S.
- Affiliations
- University of New Mexico (US)
- ORCID
- Goodwin, J. S.
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-03-01
- Volume
- 45
- Issue
- 2
- Pages
- M45-M48
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W1993142368
- Cited by
- 303
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 15
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag006086-04)
- U.S. Public Health Service
- National Institute on Aging (AG 02049, AG 06086)
- National Center for Research Resources (RR 00997, M01RR000997)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- cell-mediated immunity, anergy, mortality prediction, morbidity, older adults, phytohemagglutinin, mitogen stimulation, pneumonia, cancer mortality, all-cause mortality, aging
- MeSH terms
- Aged, Aging, Female, Follow-Up Studies, Humans, Hypersensitivity, Delayed, Immunity, Cellular, Lymphocyte Activation, Male, Middle Aged, Mitogens, Morbidity, Mortality, Neoplasms, Phytohemagglutinins, Probability, Skin Tests, Cohort Studies, Survival Rate, Proportional Hazards Models
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