Determinants of change in total cholesterol and HDL-C with age: the Framingham Study
Abstract
OBJECTIVE: The purpose of the study was to assess the determinants of change of total cholesterol and high density lipoprotein cholesterol (HDL-C) change in an adult population. METHODS: The prospective cohort was examined at baseline and eight years later. A total of 2,222 men and 2,677 women age 20-79 years at baseline were included. Analyses were performed in 15-year age groups, and persons with cardiovascular disease or cancer during the observation period were excluded. RESULTS: In longitudinal analyses, body mass index (BMI) and plasma total cholesterol levels of each rose in concert among younger age groups, whereas levels declined in older individuals. Mean levels of BMI and total cholesterol peaked at a later age in women than in men. The corresponding changes in HDL-C were negative at all ages, and greater declines were seen in the elderly. A decrease in plasma total cholesterol was highly associated with greater age and a decrease in body mass index over the study interval, whereas the decline in HDL-C was proportional to change in body mass index. These changes remained significant after adjustment for baseline age and change in alcohol intake, cigarette consumption, diuretic use, and oral estrogen use. CONCLUSIONS: The rise in plasma total cholesterol among apparently healthy young men and women and its fall in the elderly are significantly associated with similar trends for obesity. The key determinants of a decline in HDL-C are an increase in obesity and advancing age itself. A decline in total cholesterol and in HDL-C is particularly common among the elderly, and it can be expected to occur without specific dietary or pharmacologic intervention.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The annual change in total cholesterol level is the combined effect from BMI change and aging, predicted separately using polynomial regression equations derived from Wilson et al.
“The annual change in total cholesterol level is the combined effect from BMI change and aging, which were predicted separately using polynomial regression equations derived based on findings from Wilson et al [24].”
Cites
Still being checked.
Cited by
Sorted by citations
Avenell, A., Broom, J., Brown, T., Poobalan, A., Aucott, L., Stearns, S., Smith, W., Jung, R., Campbell, M., & Grant, A. (2004) · Health Technology Assessment · doi:10.3310/hta8210 · Cited by 1,041 · see citing works
Strength Training in the Elderly
Hurley, B. F., & Roth, S. M. (2000) · Sports Medicine · doi:10.2165/00007256-200030040-00002 · Cited by 327 · see citing works
Wilson, P. W. F., Hoeg, J. M., D’Agostino, R. B., Silbershatz, H., Belanger, A. J., Poehlmann, H. W., O’Leary, D. H., & Wolf, P. A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708213370802 · Cited by 319 · see citing works
Self-citationNonalcoholic fatty liver disease and aging: Epidemiology to management
Bertolotti, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14185 · Cited by 309 · see citing works
Plasma Total Cholesterol Level as a Risk Factor for Alzheimer Disease
Tan, Z. S., Seshadri, S. S., Beiser, A., Wilson, P. W. F., Kiel, D. P., Tocco, M., D’Agostino, R. B., & Wolf, P. A. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.9.1053
Self-citationTotal, LDL, and HDL Cholesterol Decrease With Age in Older Men and Women
Ferrara, A. M., Barrett-Connor, E. L., & Shan, J. (1997) · Circulation · doi:10.1161/01.cir.96.1.37 · Cited by 257 · see citing works
Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum
Gorgels, T. G. M. F., Hu, X., Scheffer, G. L., van der Wal, A. C., Toonstra, J., de Jong, P. T. V. M., Kuppevelt, T. H. V., Levelt, C. N., de Wolf, A., Loves, W. J. P., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi183 · Cited by 206 · see citing works
Plasma HDL Levels Highly Correlate With Cognitive Function in Exceptional Longevity
Atzmon, G., Gabriely, I., Greiner, W., Davidson, D., Schechter, C. B., & Barzilai, N. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.11.m712 · Cited by 164 · see citing works
Lin, Y.-C., Hsiao, T.-J., & Chen, P. (2009) · Chronobiology International · doi:10.1080/07420520902929029 · Cited by 156 · see citing works
Interrelationships Among HDL Metabolism, Aging, and Atherosclerosis
Walter, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.181438 · Cited by 135 · see citing works
Morgan, A. E., Mooney, K. M., Wilkinson, S. J., Pickles, N. A., & Auley, M. T. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.03.008 · Cited by 136 · see citing works
Offspring of Centenarians Have a Favorable Lipid Profile
Barzilai, N., Gabriely, I., Gabriely, M., Iankowitz, N., & Sorkin, J. D. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49013.x · Cited by 119 · see citing works
Does serum cholesterol contribute to vertebral bone loss in postmenopausal women?
Tankó, L. B., Bagger, Y. Z., Nielsen, S. B., & Christiansen, C. (2003) · Bone · doi:10.1016/s8756-3282(02)00918-3 · Cited by 117 · see citing works
Caveolins and macrophage lipid metabolism
Gargalovic, P. S., & Dory, L. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r200005-jlr200 · Cited by 104 · see citing works
The Effect of Cardiorespiratory Fitness on Age-Related Lipids and Lipoproteins
Park, Y., Sui, X., Liu, J., Zhou, H., Kokkinos, P. F., Lavie, C. J., Hardin, J. W., & Blair, S. N. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.517 · Cited by 102 · see citing works
Correlation between serum lipid concentrations and psychological distress
Chen, C. C., Lu, F., Wu, J., & Chang, C. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00231-1 · Cited by 102 · see citing works
Association of Apo E Polymorphism With Plasma Lipid Levels in a Multiethnic Elderly Population
Pablos-Méndez, A., Mayeux, R. P., Ngai, C. I., Shea, S., & Berglund, L. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3534 · Cited by 101 · see citing works
Özbey, N., Sencer, E., Molvalilar, S., & Orhan, Y. (2002) · Endocrine Journal · doi:10.1507/endocrj.49.503 · Cited by 96 · see citing works
Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia
Vasunilashorn, S., Crimmins, E. M., Kim, J. K., Winking, J., Gurven, M., Kaplan, H., & Finch, C. E. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21074 · Cited by 95 · see citing works
Zanoni, P., Velagapudi, S., Yalçınkaya, M., Rohrer, L., & von Eckardstein, A. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.881 · Cited by 92 · see citing works
Low HDL levels in sepsis versus trauma patients in intensive care unit
Tanaka, S., Labreuche, J., Drumez, É., Harrois, A., Hamada, S., Vigué, B., Couret, D., Duranteau, J., & Meilhac, O. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0284-3 · Cited by 93 · see citing works
Curb, J. D., Abbott, R. D., Rodríguez, B. L., Masaki, K., Chen, R., Popper, J. S., Petrovitch, H., Ross, G. W., Schatz, I. J., Belleau, G. C., et al. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh177 · Cited by 93 · see citing works
Feng, L., Nian, S., Tong, Z., Zhu, Y. Y., Li, Y., Zhang, C., Bai, X., Luo, X., Wu, M., & Yan, Z. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034226 · Cited by 92 · see citing works
Wagner, M., Helmer, C., Tzourio, C., Berr, C., Proust‐Lima, C., & Samieri, C. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2004 · Cited by 86 · see citing works
Sui, X., Sarzynski, M. A., Lee, D.-C., & Kokkinos, P. F. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.02.006 · Cited by 85 · see citing works
Wong, F. L., Yamada, M., Sasaki, H., Kodama, K., & Hosoda, Y. (1999) · Radiation Research · doi:10.2307/3580213 · Cited by 83 · see citing works
Age-Related Changes in Risk Factor Effects on the Incidence of Coronary Heart Disease
Abbott, R. D., Curb, J. D., Rodríguez, B. L., Masaki, K., Yano, K., Schatz, I. J., Ross, G. W., & Petrovitch, H. (2002) · Annals of Epidemiology · doi:10.1016/s1047-2797(01)00309-x · Cited by 83 · see citing works
Serum High-Density Lipoprotein Cholesterol and Risk of Non-Hodgkin Lymphoma
Lim, U., Gayles, T., Katki, H. A., Stolzenberg‐Solomon, R. Z., Weinstein, S. J., Pietinen, P., Taylor, P. R., Virtamo, J. R. K., & Albanes, D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0212 · Cited by 82 · see citing works
Zuliani, G., Volpato, S., Blé, A., Bandinelli, S., Corsi, A. M., Lauretani, F., Paolisso, G., Fellin, R., & Ferrucci, L. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.024 · Cited by 81 · see citing works
Stabilization of Caveolin-1 by Cellular Cholesterol and Scavenger Receptor Class B Type I
Frank, P. G., Marcel, Y. L., Connelly, M. A., Lublin, D. M., Franklin, V., Williams, D. L., & Lisanti, M. P. (2002) · Biochemistry · doi:10.1021/bi0257078 · Cited by 80 · see citing works
Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins
Frank, P. G., Galbiati, F., Volonté, D., Razani, B., Cohen, D. E., Marcel, Y. L., & Lisanti, M. P. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.5.c1204 · Cited by 76 · see citing works
Age-related changes in risk factor effects on the incidence of thromboembolic and hemorrhagic stroke
Abbott, R. D., Curb, J. D., Rodríguez, B. L., Masaki, K., Popper, J. S., Ross, G. W., & Petrovitch, H. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00611-x · Cited by 73 · see citing works
Hillen, T., Nieczaj, R., Münzberg, H., Schaub, R., Borchelt, M., & Steinhagen‐Thiessen, E. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00681.x · Cited by 67 · see citing works
Age-related changes in total and high-density-lipoprotein cholesterol in elderly Dutch men.
Weijenberg, M. P., Feskens, E. J. M., & Kromhout, D. (1996) · American Journal of Public Health · doi:10.2105/ajph.86.6.798 · Cited by 64 · see citing works
Volpato, S., Zuliani, G., Guralnik, J. M., Palmieri, E., & Fellin, R. (2001) · Gerontology · doi:10.1159/000052768 · Cited by 63 · see citing works
Zeller, M., Masson, D., Farnier, M., Lorgis, L., Deckert, V., de Barros, J.-P. P., Desrumaux, C. M., Sicard, P., Grober, J., Blache, D., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.052 · Cited by 63 · see citing works
Hernández-Bautista, R., Alarcón-Aguilar, F. J., Escobar-Villanueva, M. D. C., Almanza-Pérez, J. C., Merino-Aguilar, H., Fainstein, M. K., & López‐Díazguerrero, N. E. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150711473 · Cited by 62 · see citing works
Abbott, R. D., Sharp, D. S., Burchfiel, C. M., Curb, J. D., Rodríguez, B. L., Hakim, A. A., & Yano, K. (1997) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00043-4 · Cited by 63 · see citing works
Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
Wellington, C. L. (2004) · Clinical Genetics · doi:10.1111/j.0009-9163.2004.00280.x · Cited by 62 · see citing works
Chen, F., Su, W., Becker, S. H., Payne, M., Castro Sweet, C. M., Peters, A. L., & Dall, T. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0163627 · Cited by 60 · see citing works
“The annual change in total cholesterol level is the combined effect from BMI change and aging, which were predicted separately using polynomial regression equations derived based on findings fromWilson et al [24].”
MethodPolymorphisms at the 5'-end of the apolipoprotein AI gene and severity of coronary artery disease.
Wang, X. L., Liu, S. X., McCredie, R. M., & Wilcken, D. E. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118802 · Cited by 58 · see citing works
Aging and HDL Metabolism in Elderly People More Than 100 Years Old
Arai, Y., & Hirose, N. (2004) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11.246 · Cited by 57 · see citing works
Ray, J. A., Boye, K. S., Yurgin, N., Valentine, W. J., Roze, S., McKendrick, J., Tucker, D. M. D., FOOS, V., & Palmer, A. J. (2007) · Current Medical Research and Opinion · doi:10.1185/030079907x178685 · Cited by 55 · see citing works
Matthan, N. R., Jalbert, S. M., Barrett, P. H. R., Dolnikowski, G. G., Schaefer, E. J., & Lichtenstein, A. H. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.163931 · Cited by 56 · see citing works
Effect of biological sex on human circulating lipidome: An overview of the literature
Tabassum, R., Widén, E., & Ripatti, S. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117274 · Cited by 55 · see citing works
Wilsgaard, T., & Arnesen, E. (2004) · Annals of Epidemiology · doi:10.1016/j.annepidem.2003.08.004 · Cited by 55 · see citing works
Hopstock, L. A., Bønaa, K. H., Eggen, A. E., Grimsgaard, S., Jacobsen, B. K., Løchen, M., Mathiesen, E. B., Njølstad, I., & Wilsgaard, T. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015001 · Cited by 54 · see citing works
Value of Lifestyle Intervention to Prevent Diabetes and Sequelae
Dall, T. M., Storm, M. V., Semilla, A. P., Wintfeld, N., O’Grady, M., & Venkat Narayan, K. M. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.10.003 · Cited by 53 · see citing works
Simpson, S. H., Johnson, J. A., & Tsuyuki, R. T. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.6.627.34538 · Cited by 50 · see citing works
HDL Genetics: Candidate Genes, Genome Wide Scans and Gene-Environment Interactions
Ordovás, J. M. (2002) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1021769523568 · Cited by 50 · see citing works
de Freitas, E. V., Brandão, A. A., Pozzan, R., Magalhães, M. E. C., Fonseca, F. L., Pizzi, O. L., Campana, É. M. G., & Brandão, A. P. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.03.022 · Cited by 49 · see citing works
Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes
Pokharel, D. R., Khadka, D., Sigdel, M., Yadav, N. K., Acharya, S., Kafle, R., Sapkota, R. M., & Sigdel, T. K. (2017) · BMC Research Notes · doi:10.1186/s13104-017-2465-4 · Cited by 47 · see citing works
Current understanding of the role of high-density lipoproteins in atherosclerosis and senescence
Nofer, J., Walter, M., & Assmann, G. (2005) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.3.6.1071 · Cited by 47 · see citing works
Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity
Milman, S., Atzmon, G., Crandall, J. P., & Barzilai, N. (2013) · Current Vascular Pharmacology · doi:10.2174/1570161111666131219101551 · Cited by 44 · see citing works
Poon, A. K., Meyer, M. L., Tanaka, H., Selvin, E., Pankow, J. S., Zeng, D., Loehr, L. R., Knowles, J. W., Rosamond, W. D., & HEISS, G. M. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-0986-y · Cited by 46 · see citing works
Downer, B. G., Estus, S., Katsumata, Y., & Fardo, D. W. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph111010663 · Cited by 45 · see citing works
Rodríguez, C. J., Pablos-Méndez, A., Palmas, W., Lantigua, R., Mayeux, R. P., & Berglund, L. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02197-x · Cited by 45 · see citing works
Etiologic factors in progression of carotid stenosis: A 10-year study in 905 patients
Garvey, L., Makaroun, M. S., Muluk, V. S., Webster, M. W., & Muluk, S. C. (2000) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(00)70065-6 · Cited by 44 · see citing works
Calvo, I., Olivar, J. E. R., Martínez, E., Rico, A., Diaz, J. M. Q., & Gimena, M. (2012) · PubMed · doi:10.3305/nh.2012.27.5.5888 · Cited by 43 · see citing works
Novel rare mutations and promoter haplotypes in ABCA1 contribute to low‐HDL‐C levels
Slatter, T., Jones, G. T., Williams, M., van Rij, A., & McCormick, S. P. A. (2008) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00940.x · Cited by 42 · see citing works
Plasma biomarkers of mouse aging
Ding, J., & Kopchick, J. J. (2010) · AGE · doi:10.1007/s11357-010-9179-z · Cited by 41 · see citing works
Ferreira, M. G., Valente, J. G., Gonçalves‐Silva, R. M. V., & Sichieri, R. (2006) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2006000200008 · Cited by 41 · see citing works
Abbott, R., Yano, K., Hakim, A. A., Burchfiel, C., Sharp, D. S., Rodríguez, B. L., & Curb, J. D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00310-5 · Cited by 41 · see citing works
The role of cardiorespiratory fitness on plasma lipid levels
Parto, P., Lavie, C., Swift, D., & Sui, X.-M. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1092384 · Cited by 40 · see citing works
Repurposing drugs to fight aging: The difficult path from bench to bedside
Vaiserman, A. M., Koliada, A. K., Lushchak, O. V., & Castillo, M. J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21773 · Cited by 42 · see citing works
Lahoz, C. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00094-7 · Cited by 40 · see citing works
Kuzuya, M., Ando, F., Iguchi, A., & Shimokata, H. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.05.040 · Cited by 39 · see citing works
Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT
Lin, Y.-C., Hsiao, T.-J., & Chen, P. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5654 · Cited by 38 · see citing works
Age-Related Changes in Biomarkers: Longitudinal Data from a Population-Based Sample
Glei, D. A., Goldman, N., Lin, Y.-H., & Weinstein, M. (2011) · Research on Aging · doi:10.1177/0164027511399105 · Cited by 37 · see citing works
Pulkkinen, A., Viitanen, L., Kareinen, A., Lehto, S., & Laakso, M. (2000) · Diabetes Care · doi:10.2337/diacare.23.6.791 · Cited by 37 · see citing works
Stylianou, I. M., Tsaih, S., DiPetrillo, K., Ishimori, N., Li, R., Paigen, B. J., & Churchill, G. A. (2006) · Genetics · doi:10.1534/genetics.106.059717 · Cited by 35 · see citing works
Early Nutritional Screening of Older Adults
Stechmiller, J. K. (2003) · Journal of Infusion Nursing · doi:10.1097/00129804-200305000-00009 · Cited by 35 · see citing works
Changes in serum lipid levels during a 10 year period in a large Japanese population
Kuzuya, M., Ando, F., Iguchi, A., & Shimokata, H. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00009-6 · Cited by 33 · see citing works
Distribution and Correlates of Lipids and Lipoproteins in Elderly Japanese-American Men
Burchfiel, C. M., Abbott, R. D., Sharp, D. S., Curb, J. D., Rodríguez, B. L., & Yano, K. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.11.1356 · Cited by 33 · see citing works
Cho, K., Park, H., Kim, S., & Kim, J.-R. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16183329 · Cited by 32 · see citing works
Schmidt, D. A., Ellersieck, M. R., Cranfield, M. R., & Karesh, W. B. (2006) · Journal of Zoo and Wildlife Medicine · doi:10.1638/05-040.1 · Cited by 32 · see citing works
Frank, P. G., Pedraza, A. J., Cohen, D. E., & Lisanti, M. P. (2001) · Biochemistry · doi:10.1021/bi0106437 · Cited by 31 · see citing works
Bertolotti, M., Mussi, C., Pellegrini, E., Magni, A., Puppo, M. D., Ognibene, S., Carulli, L., Anzivino, C., Baldelli, E., Loria, P., et al. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s57714 · Cited by 31 · see citing works
Longitudinal changes in serum lipids in older people The Turku Elderly Study 1991–2006
Upmeier, E., Lavonius, S., Heinonen, P., Viitanen, M. H., Isoaho, H., Arve, S., & Lehtonen, A. (2011) · Age and Ageing · doi:10.1093/ageing/afq180 · Cited by 31 · see citing works
Gao, T., Wilkins, J. T., Zheng, Y., Joyce, B. T., Jacobs, D. R., Schreiner, P. J., Horvath, S., Greenland, P., Lloyd‐Jones, D. M., & Hou, L. (2022) · Clinical Epigenetics · doi:10.1186/s13148-021-01222-2 · Cited by 30 · see citing works
Lipid Profile Components and Subclinical Cerebrovascular Disease in the Northern Manhattan Study
Willey, J. Z., Gardener, H. E., Moon, Y. P., Yoshita, M., DeCarli, C. S., Cheung, Y. K., Sacco, R. L., Elkind, M. S. V., & Wright, C. B. (2014) · Cerebrovascular Diseases · doi:10.1159/000362920 · Cited by 30 · see citing works
Postprandial Metabolic Responses Differ by Age Group and Physical Activity Level
Emerson, S. R., Kurti, S. P., Emerson, E. M., Cull, B. J., Casey, K., Haub, M. D., & Rosenkranz, S. K. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0956-6 · Cited by 28 · see citing works
The care gap: underuse of statin therapy in the elderly
Gaw, A. J. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1368-5031.2004.00300.x · Cited by 27 · see citing works
Lipoproteins, Vascular-Related Genetic Factors, and Human Longevity
Panza, F., D’Introno, A., Capurso, C. A., Colacicco, A. M., Seripa, D., Pilotto, A., Santamato, A., Capurso, A., & Solfrizzi, V. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0537 · Cited by 27 · see citing works
양중석 (2015) · CHINESE LITERATURE · doi:10.21192/scll.83..201505.001 · Cited by 26 · see citing works
Body Mass Index and Coronary Heart Disease Risk Score: The Tromsø Study, 1979 to 2001
Wilsgaard, T., & Arnesen, E. (2006) · Annals of Epidemiology · doi:10.1016/j.annepidem.2006.05.006 · Cited by 26 · see citing works
Heng, C., Low, P., & Saha, N. (2001) · Pediatric Research · doi:10.1203/00006450-200104000-00013 · Cited by 26 · see citing works
Koohi, F., Khalili, D., Mansournia, M. A., Hadaegh, F., & Soori, H. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02966-4 · Cited by 25 · see citing works
Scranton, R. E., Sesso, H. D., Stampfer, M. J., Levenson, J. W., Buring, J. E., & Gaziano, J. M. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.11.018 · Cited by 25 · see citing works
Differences in DBA/1J and DBA/2J reveal lipid QTL genes
Stylianou, I. M., Langley, S. R., Walsh, K., Chen, Y., Revenu, C., & Paigen, B. J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800244-jlr200 · Cited by 24 · see citing works
Correlation between white blood cell count and metabolic syndrome in adolescence
Hsieh, C., Pei, D., Kuo, S., Chen, C., TSAI, S., LAI, C., LEE, C., Wu, C., Hung, Y.-J., & Hsieh, M.-C. (2007) · Pediatrics International · doi:10.1111/j.1442-200x.2007.02450.x · Cited by 24 · see citing works
HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2q
North, K. E., Martin, L. J., Dyer, T., Comuzzie, A. G., & Williams, J. T. (2003) · BMC Genetics · doi:10.1186/1471-2156-4-s1-s98 · Cited by 24 · see citing works
Perona, J. S., Cañizares, J., Montero, E., Sánchez-Domínguez, J. M., & Ruíz-Gutiérrez, V. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003852 · Cited by 24 · see citing works
Laclaustra, M., González-García, M. P., Casasnovas, J. A., Luengo, E., León-Latre, M., Pérez, P. P., Ligorit, A. D. R., Giner, A., & Montero, I. J. F. (2006) · Revista Española de Cardiología · doi:10.1157/13091368 · Cited by 23 · see citing works
Jeng, J., Sacco, R. L., Kargman, D. E., Boden-Albala, B. M., Paik, M. C., Jones, J. S., & Berglund, L. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00246-0 · Cited by 23 · see citing works
García, J. B., de Sá, E. L., Lopez-Sendon, J. L., Osuna, P. P., García‐Morán, E., Bethencourt, A., Bosch, X., Rabadán, I. R., Santos, R. C., & Valle, V. (2000) · Revista Española de Cardiología · doi:10.1016/s0300-8932(00)75281-x · Cited by 23 · see citing works
C-Reactive protein and lipid parameters in older persons aged 80 years and older
Cesari, M., Onder, G., Zamboni, V., Capoluongo, E., Russo, A., Bernabei, R., Pahor, M., & Landi, F. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0168-9 · Cited by 22 · see citing works
Bakx, J. C., van den Hoogen, H. J. M., Deurenberg, P., van Doremalen, J., & van den Bosch, W. J. H. M. (2000) · Preventive Medicine · doi:10.1006/pmed.1999.0608 · Cited by 22 · see citing works
Stern, N., Grosskopf, I., Shapira, I., Kisch, E. S., Isaacov, A., Limor, R., Baz, M., Leshem, Y. A., FLATAU, E., Miller, A., et al. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00724.x · Cited by 22 · see citing works
A negative association between total cholesterol and bone mineral density in US adult women
Fang, W., Peng, P., Xiao, F., He, W., Wei, Q., & He, M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.937352 · Cited by 21 · see citing works
- Authors
- Wilson, P. W. F., Anderson, K. M., Harri, T., Kannel, W. B., & Castelli, W. P.
- Affiliations
- Framingham Heart Study (US)
- National Institutes of Health (US)
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-11-01
- Volume
- 49
- Issue
- 6
- Pages
- M252-M257
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W1998598117
- Cited by
- 223
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 10 · 2019: 8 · 2018: 3 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 8 · 2012: 5
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- total cholesterol, HDL cholesterol, age-related changes, body mass index, obesity, aging, sex differences, Framingham Heart Study, longitudinal cohort, cardiovascular risk factors
- MeSH terms
- Adult, Age Factors, Aged, Aging, Alcohol Drinking, Cholesterol, Cross-Sectional Studies, Diuretics, Estrogens, Female, Follow-Up Studies, Humans, Cholesterol, HDL, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Sex Factors, Smoking, Cohort Studies, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
