The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Brain extracellular matrix
Abstract
The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant. Matrix proteins common in other tissues are nearly absent in adult brain. The brain extracellular matrix appears to have trophic effects on neuronal cells and affect neurite outgrowth. The unique composition of this matrix may be responsible for the resistance of brain tissue toward invasion by tumors of non-neuronal origin.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The striking feature of the brain ECM is the prominence of proteoglycans and hyaluronan with the exception of basement membrane structures (Ruoslahti, 1996).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Ruoslahti, 1996
In the citing paper
“The current concept of supramolecular organization and assembly of PNN was first proposed by Ruoslahti (1996) and designated as “HLT (hyaluronan, lecticans and TN-R)” model by Yamaguchi (2000) (Fig. 2).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Ruoslahti, 1996
Citations
Cites
Proteoglycans as modulators of growth factor activities
Ruoslahti, E. I., & Yamaguchi, Y. (1991) · Cell · doi:10.1016/0092-8674(91)90308-l · Cited by 1,342
Self-citationWillis, R. A. (1948) · Butterworths eBooks · Cited by 1,254
Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation
Lasky, L. A. (1992) · Science · doi:10.1126/science.1439808 · Cited by 1,236
Varki, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7390 · Cited by 946
Proteoglycans in Cell Regulation
Ruoslahti, E. I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80001-1 · Cited by 679
Self-citationMultiple domains of the large fibroblast proteoglycan, versican.
Zimmermann, D., & Ruoslahti, E. I. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08447.x · Cited by 652
Self-citationGladson, C. L., & Cheresh, D. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115516 · Cited by 415
Chondroitin Sulfate as a Regulator of Neuronal Patterning in the Retina
Brittis, P. A., Canning, D. R., & Silver, J. (1992) · Science · doi:10.1126/science.1738848 · Cited by 415
Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties.
Faissner, A., Clement, A. M., Lochter, A., Streit, A., Mandl, C., & Schachner, M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.3.783 · Cited by 354
Schönherr, E., Järveläinen, H., Sandell, L. J., & Wight, T. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47419-x · Cited by 335
Rauch, U., Karthikeyan, L., Maurel, P., Margolis, R. U., & Margolis, R. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41808-x · Cited by 333
Milev, P., Friedlander, D. R., Sakurai, T., Karthikeyan, L., Flad, M., Margolis, R. K., Grumet, M., & Margolis, R. U. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1703 · Cited by 328
Hyaluronate binding properties of versican.
LeBaron, R. G., Zimmermann, D., & Ruoslahti, E. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50191-0 · Cited by 317
Self-citationThe extracellular matrix of the central and peripheral nervous systems: structure and function
Rutka, J. T., Apodaca, G., Stern, R., & Rosenblum, M. L. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.69.2.0155 · Cited by 307
Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix.
Knudson, C. B. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.3.825 · Cited by 280
Hoffman, S., Crossin, K., & Edelman, G. M. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.2.519 · Cited by 274
Oakley, R. A., & Tosney, K. W. (1991) · Developmental Biology · doi:10.1016/s0012-1606(05)80017-x · Cited by 260
Grumet, M., Milev, P., Sakurai, T., Karthikeyan, L., Bourdon, M. A., Margolis, R. K., & Margolis, R. U. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32692-3 · Cited by 255
Dours-Zimmermann, M. T., & Zimmermann, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30089-2 · Cited by 249
Herndon, M. E., & Lander, A. D. (1990) · Neuron · doi:10.1016/0896-6273(90)90148-9 · Cited by 245
Krusius, T., Gehlsen, K. R., & Ruoslahti, E. I. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45176-9 · Cited by 188
Self-citationFuss, B., Wintergerst, E. S., Bartsch, U., & Schachner, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.5.1237 · Cited by 179
Nörenberg, U., Ville, H., Wolff, J. M., Frank, R. W., & Rathjen, F. G. (1992) · Neuron · doi:10.1016/0896-6273(92)90199-n · Cited by 160
The versican C-type lectin domain recognizes the adhesion protein tenascin-R.
Aspberg, A., Binkert, C., & Ruoslahti, E. I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10590 · Cited by 142
Self-citationSnow, A. D., Sekiguchi, R., Nochlin, D., Kalaria, R. N., & Kimata, K. (1994) · PubMed Central · Cited by 132
Meyer‐Puttlitz, B., Milev, P., Junker, E., Zimmer, I., Margolis, R. U., & Margolis, R. K. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052327.x · Cited by 124
Asher, R., Perides, G., Vanderhaeghen, J., & Bignami, A. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490280314 · Cited by 120
A segment of the cartilage proteoglycan core protein has lectin-like activity.
Halberg, D. F., Proulx, G., Doege, K. J., Yamada, Y., & Drickamer, K. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76567-3 · Cited by 116
Bignami, A., Perides, G., & Rahemtulla, F. G. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490340110 · Cited by 109
Paganetti, P., Caroni, P., & Schwab, M. E. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.6.2281 · Cited by 100
Chiquet‐Ehrismann, R., Hagios, C., & Matsumoto, K. (1994) · PubMed · Cited by 95
Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes.
Moses, M. A., Sudhalter, J., & Langer, R. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.2.475 · Cited by 94
[6] Aggrecan-versican-neurocan family of proteoglycans
Margolis, R. U., & Margolis, R. K. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)45008-0 · Cited by 93
Fryer, H. J., Kelly, G. M., Molinaro, L., & Hockfield, S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50175-2 · Cited by 92
Differential effects of glycosaminoglycans on neurite growth on laminin and L1 substrates
Dou, C., & Levine, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08053.1995 · Cited by 85
Isolation of a large aggregating proteoglycan from human brain.
Perides, G., Rahemtulla, F. G., Lane, W. S., Asher, R. A., & Bignami, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35919-2 · Cited by 73
Iwata, M., & Carlson, S. S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-01-00195.1993 · Cited by 63
Ujita, M., Shinomura, T., Ito, K., Kitagawa, Y., & Kimata, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47027-5 · Cited by 52
Junghans, U., Koops, A., Westmeyer, A., Kappler, J., Meyer, H. E., & Müller, H. W. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00655.x · Cited by 51
Hennig, A. K., Mangoura, D. A., & Schwartz, N. B. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90146-2 · Cited by 26
Cited by
Sorted by citations
Extracellular Matrix Assembly: A Multiscale Deconstruction
Mouw, J. K., Ou, G., & Weaver, V. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3902 · Cited by 1,534
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
Extracellular space structure revealed by diffusion analysis
Nicholson, C., & Syková, E. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01261-2 · Cited by 914
Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Metadata
- Authors
- Ruoslahti, E.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Ruoslahti, Erkki
- ORCID
- Ruoslahti, Erkki
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996
- Volume
- 6
- Issue
- 5
- Pages
- 489-492
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W1988575276
- Cited by
- 467
- References
- 40
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 22 · 2021: 28 · 2020: 35 · 2019: 23 · 2018: 17 · 2017: 19 · 2016: 18 · 2015: 17 · 2014: 25 · 2013: 16 · 2012: 19
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glycobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karolinska Institutet
- National Institutes of Health (5p01ca028896-15)
- National Cancer Institute (CA30199, CA 28896, P30CA030199)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- brain extracellular matrix, lecticans, proteoglycans, hyaluronic acid, tenascin, matrix protein, neurite outgrowth
- MeSH terms
- Adult, Brain Chemistry, Extracellular Matrix, Humans, Hyaluronic Acid, Protein Binding, Proteoglycans, Tenascin, Lectins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
