The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Brain extracellular matrix
Abstract
The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant. Matrix proteins common in other tissues are nearly absent in adult brain. The brain extracellular matrix appears to have trophic effects on neuronal cells and affect neurite outgrowth. The unique composition of this matrix may be responsible for the resistance of brain tissue toward invasion by tumors of non-neuronal origin.
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In the citing paper
“The striking feature of the brain ECM is the prominence of proteoglycans and hyaluronan with the exception of basement membrane structures (Ruoslahti, 1996).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Ruoslahti, 1996
In the citing paper
“The current concept of supramolecular organization and assembly of PNN was first proposed by Ruoslahti (1996) and designated as “HLT (hyaluronan, lecticans and TN-R)” model by Yamaguchi (2000) (Fig. 2).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Ruoslahti, 1996
Citations
Cites
Proteoglycans as modulators of growth factor activities
Ruoslahti, E. I., & Yamaguchi, Y. (1991) · Cell · doi:10.1016/0092-8674(91)90308-l · Cited by 1,342
Self-citationWillis, R. A. (1948) · Butterworths eBooks · Cited by 1,254
Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation
Lasky, L. A. (1992) · Science · doi:10.1126/science.1439808 · Cited by 1,236
Varki, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7390 · Cited by 946
Proteoglycans in Cell Regulation
Ruoslahti, E. I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80001-1 · Cited by 679
Self-citationMultiple domains of the large fibroblast proteoglycan, versican.
Zimmermann, D., & Ruoslahti, E. I. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08447.x · Cited by 652
Self-citationGladson, C. L., & Cheresh, D. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115516 · Cited by 415
Chondroitin Sulfate as a Regulator of Neuronal Patterning in the Retina
Brittis, P. A., Canning, D. R., & Silver, J. (1992) · Science · doi:10.1126/science.1738848 · Cited by 415
Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties.
Faissner, A., Clement, A. M., Lochter, A., Streit, A., Mandl, C., & Schachner, M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.3.783 · Cited by 354
Schönherr, E., Järveläinen, H., Sandell, L. J., & Wight, T. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47419-x · Cited by 335
Cited by
Sorted by citations
Extracellular Matrix Assembly: A Multiscale Deconstruction
Mouw, J. K., Ou, G., & Weaver, V. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3902 · Cited by 1,534
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
Extracellular space structure revealed by diffusion analysis
Nicholson, C., & Syková, E. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01261-2 · Cited by 914
Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Metadata
- Authors
- Ruoslahti, E.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Ruoslahti, Erkki
- ORCID
- Ruoslahti, Erkki
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996
- Volume
- 6
- Issue
- 5
- Pages
- 489-492
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W1988575276
- Cited by
- 467
- References
- 40
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 22 · 2021: 28 · 2020: 35 · 2019: 23 · 2018: 17 · 2017: 19 · 2016: 18 · 2015: 17 · 2014: 25 · 2013: 16 · 2012: 19
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glycobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karolinska Institutet
- National Institutes of Health (5p01ca028896-15)
- National Cancer Institute (CA30199, CA 28896, P30CA030199)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- brain extracellular matrix, lecticans, proteoglycans, hyaluronic acid, tenascin, matrix protein, neurite outgrowth
- MeSH terms
- Adult, Brain Chemistry, Extracellular Matrix, Humans, Hyaluronic Acid, Protein Binding, Proteoglycans, Tenascin, Lectins
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