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Cited by 518

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Siglecs—the major subfamily of I-type lectins

Varki, Ajit, Angata, Takashi·2006·Glycobiology

Abstract

Animal glycan-recognizing proteins can be broadly classified into two groups-lectins (which typically contain an evolutionarily conserved carbohydrate-recognition domain [CRD]) and sulfated glycosaminoglycan (SGAG)-binding proteins (which appear to have evolved by convergent evolution). Proteins other than antibodies and T-cell receptors that mediate glycan recognition via immunoglobulin (Ig)-like domains are called "I-type lectins." The major homologous subfamily of I-type lectins with sialic acid (Sia)-binding properties and characteristic amino-terminal structural features are called the "Siglecs" (Sia-recognizing Ig-superfamily lectins). The Siglecs can be divided into two groups: an evolutionarily conserved subgroup (Siglecs-1, -2, and -4) and a CD33/Siglec-3-related subgroup (Siglecs-3 and -5-13 in primates), which appear to be rapidly evolving. This article provides an overview of historical and current information about the Siglecs.

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Metadata

Authors
Varki, A., & Angata, T.
Venue
Glycobiology
Published
2005-07-13
Volume
16
Issue
1
Pages
1R-27R
ISSN
  • 0959-6658 (ISSN-L)
  • 1460-2423
OpenAlex
W2154872900
Cited by
518
References
6
FWCI
11.64
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Siglecs—the major subfamily of I-type lectins. https://app.cochat.ai/papers/10.1093/glycob/cwj008
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Varki, A., & Angata, T. (2006). Siglecs—the major subfamily of I-type lectins. Glycobiology. https://doi.org/10.1093/glycob/cwj008

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