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p53 tagged sites from human genomic DNA
Abstract
The product of the tumor suppressor gene p53 binds to DNA and activates transcription from promoters containing its consensus binding site. This activity has been hypothesized to be responsible for its biological effects. However, the total number and nature of human genomic sites with which p53 can functionally interact is unknown. In this paper, we have used a Saccharomyces cerevisiae-based screen to identify human genomic sequences that activate transcription from an adjacent reporter gene in a p53-dependent manner (p53-tagged sites, PTS). Fifty-seven different PTS were identified, and the total number of such sites in the human genome was predicted to be between 200 and 300. Almost all contained two adjacent copies of the previously defined consensus 5'-PuPuPuC(A/T)(T/A)GPyPyPy-3'. Spacing between the copies was found to be critical for sequence-specific transcriptional activation in vivo. These results further refine the nature of the genomic sequences likely to be most important for p53-mediated tumor suppression.
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“First, due to the high degeneracy of the p53‐RE, several hundred genes have been shown to be activated by p53 and to carry p53‐RE in their regulatory regions [64].”
From The TP53 tumor suppressor gene: From molecular biology to clinical investigations (2025) · cites this paper as [64]
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Cited by
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921
The multiple mechanisms that regulate p53 activity and cell fate
Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
Tanaka, H., Arakawa, H., Yamaguchi, T., Shiraishi, K., Fukuda, S., Matsui, K., Takei, Y., & Nakamura, Y. (2000) · Nature · doi:10.1038/35003506 · Cited by 904
Cellular and molecular determinants of cisplatin resistance
Perez, R. P. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00227-5 · Cited by 384
Ets target genes: past, present and future
Sementchenko, V. I., & Watson, D. K. (2000) · Oncogene · doi:10.1038/sj.onc.1204034 · Cited by 371
Metadata
- Authors
- Tokino, T., Thiagalingam, S., EI-Deiry, W. S., Waldman, T., Kinzler, K. W., & Vogelstein, B.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1994
- Volume
- 3
- Issue
- 9
- Pages
- 1537-1542
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2124637558
- Cited by
- 177
- References
- 0
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: p53 tagged sites from human genomic DNA. https://app.cochat.ai/papers/10.1093/hmg/3.9.1537
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- Tokino, T., Thiagalingam, S., EI-Deiry, W. S., Waldman, T., Kinzler, K. W., & Vogelstein, B. (1994). p53 tagged sites from human genomic DNA. Human Molecular Genetics. https://doi.org/10.1093/hmg/3.9.1537
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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