The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes
Abstract
We have identified three new members of the olfactory receptor (OR) gene family within a large segment of DNA that is duplicated with high similarity near many human telomeres. This segment is present at 3q, 15q, and 19p in each of 45 unrelated humans sampled from various populations. Additional copies are present polymorphically at 11 other subtelomeric locations. The frequency with which the block is present at some locations varies among populations. While humans carry seven to 11 copies of the OR-containing block, it is located in chimpanzee and gorilla predominantly at a single site, which is not orthologous to any of the locations in the human genome. The observation that sequences flanking the OR-containing segment are duplicated on larger and different sets of chromosomes than the OR block itself demonstrates that the segment is part of a much larger, complex patchwork of subtelomeric duplications. The population analyses and structural results suggest the types of processes that have shaped these regions during evolution. From its sequence, one of the OR genes in this duplicated block appears to be potentially functional. Our findings raise the possibility that functional diversity in the OR family is generated in part through duplications and inter-chromosomal rearrangements of the DNA near human telomeres.
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Cites
Telomeres shorten during ageing of human fibroblasts
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A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
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Telomere reduction in human colorectal carcinoma and with ageing
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Self-citationOrigin of human chromosome 2: an ancestral telomere-telomere fusion.
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Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
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Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Self-citationThe sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Self-citationStructural variation in the human genome
Feuk, L., Carson, A. R., & Scherer, S. W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1767 · Cited by 2,034
Segmental Duplications: Organization and Impact Within the Current Human Genome Project Assembly
Bailey, J. A., Yavor, A. M., Massa, H. F., Trask, B. J., & Eichler, E. E. (2001) · Genome Research · doi:10.1101/gr.187101 · Cited by 717
Self-citationOlfaction: Diverse Species, Conserved Principles
Ache, B. W., & Young, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.022 · Cited by 655
Metadata
- Authors
- Trask, B. J., Friedman, C., Martin-Gallardo, A., Rowen, L., Akinbami, C., Blankenship, J., Collins, C., Giorgi, D., Iadonato, S., Johnson, F., Kuo, W.-L., Massa, H., Morrish, T., Naylor, S., Nguyen, O. T. H., Rouquier, S., Smith, T., Wong, D. J., Youngblom, J., & van den Engh, G.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 7
- Issue
- 1
- Pages
- 13-26
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2119402784
- Cited by
- 206
- References
- 6
- FWCI
- 32.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trask, B. J., Friedman, C., Martin-Gallardo, A., Rowen, L., Akinbami, C., Blankenship, J., Collins, C., Giorgi, D., Iadonato, S., Johnson, F., Kuo, W.-L., Massa, H., Morrish, T., Naylor, S., Nguyen, O. T. H., Rouquier, S., Smith, T., Wong, D. J., Youngblom, J., & van den Engh, G. (1998). Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. Human Molecular Genetics. https://doi.org/10.1093/hmg/7.1.13
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
