The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Another recent study demonstrated a functional link between CLEC16A and disrupted mitophagy in murine splenic immune cells and showed that incomplete mitophagy predisposes clec16a knockout mice to a cascade of altered immune signaling functions resulting in pathogenic inflammation [321,322].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [322]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000298 · Cited by 2,944
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224
Self-citationAge, Neuropathology, and Dementia
Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806142 · Cited by 900
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2528 · Cited by 885
Shiba-Fukushima, K., Imai, Y., Yoshida, S., Ishihama, Y., Kanao, T., Sato, S., & Hattori, N. (2012) · Scientific Reports · doi:10.1038/srep01002 · Cited by 577 · cited 1×
“After dissipation of mitochondrial membrane potential (ΔΨm), the autophosphorylation of PINK1 is essential for its activation, promoting the recruitment of PARK2 to the mitochondria and its phosphorylation at Ser65 as an initial step of mitophagy (19,20).”
BackgroundReddy, P. H., Tripathi, R., Troung, Q., Tirumala, K., Reddy, T. P., Anekonda, V., Shirendeb, U. P., Calkins, M. J., Reddy, A. P., Mao, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.011 · Cited by 394
Yu, W. H., Kumar, A., Peterhoff, C., Shapiro Kulnane, L., Uchiyama, Y., Lamb, B. T., Cuervo, A. M., & Nixon, R. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.010 · Cited by 279
Flagged first, then by citations
Research works printed but not linked: 41
- 10.1146/annurev.genet.32.1.461 · DOI · Paper page
- Zhu, 2013, Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease, J. Alzheimers Dis., 33, S253
- 10.1016/j.neuropharm.2010.04.005 · DOI
- Garcia-Escudero, 2013, Deconstructing mitochondrial dysfunction in Alzheimer disease, Oxid. Med. Cell. Longev., 2013, 162152, 10.1155/2013/162152 · DOI
- 10.1089/ars.2011.4173 · DOI · Paper page
- 10.1021/bi035345j · DOI
- 10.1016/j.febslet.2011.04.022 · DOI
- 10.2174/156720511796717131 · DOI
- 10.1016/j.freeradbiomed.2011.11.020 · DOI
- 10.1016/j.ajpath.2011.07.004 · DOI
- 10.1038/33416 · DOI · Paper page
- 10.1111/j.1471-4159.2008.05398.x · DOI
- 10.1083/jcb.200507002 · DOI · Paper page
- 10.1038/ncomms2016 · DOI
- 10.1093/hmg/ddq419 · DOI · Paper page
- 10.1002/embr.201337294 · DOI
- 10.1093/jnen/64.2.113 · DOI · Paper page
- 10.4161/auto.7.8.15761 · DOI
- 10.1016/j.tcb.2003.12.002 · DOI
- 10.1016/j.neurobiolaging.2004.09.018 · DOI
- 10.1016/j.cell.2010.05.008 · DOI · Paper page
- 10.1097/01.jnen.0000240476.73532.b0 · DOI
- 10.4161/auto.4872 · DOI
- 10.1016/S0891-5849(02)01049-3 · DOI
- 10.1073/pnas.91.25.11993 · DOI · Paper page
- 10.1371/journal.pone.0053040 · DOI
- Ozawa K. , Komatsubara A.T. , Nishimura Y. , Sawada T. , Kawafune H. , Tsumoto H. , Tsuji Y. , Zhao J. , Kyotani Y. , Tanaka T. et al . (2013) S-nitrosylation regulates mitochondrial quality control via activation of parkin. Sci. Rep., 3, 2202. · DOI
- 10.1073/pnas.85.21.7972 · DOI
- Yoshimori, 1991, Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells, J. Biol. Chem., 266, 17707, 10.1016/S0021-9258(19)47429-2 · DOI
- 10.1111/febs.13540 · DOI
- 10.1093/cercor/bht101 · DOI
- Wang, 2014, Oxidative stress and mitochondrial dysfunction in Alzheimer's disease, Biochim. Biophys. Acta, 1842, 1240, 10.1016/j.bbadis.2013.10.015 · DOI · Paper page
- 10.4161/auto.4625 · DOI
- 10.2353/ajpath.2007.060524 · DOI
- Polgar, 1987, Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B, J. Biol. Chem., 262, 14448, 10.1016/S0021-9258(18)47815-5 · DOI
- Lonskaya, 2013, Diminished parkin solubility and co-localization with intraneuronal amyloid-beta are associated with autophagic defects in Alzheimer's disease, J. Alzheimers Dis., 33, 231, 10.3233/JAD-2012-121141 · DOI
- 10.1016/j.nbd.2009.08.009 · DOI
- 10.1093/hmg/ddr091 · DOI
- 10.1074/jbc.M401417200 · DOI
- 10.1016/0022-1759(83)90303-4 · DOI · Paper page
- 10.1038/ncb1981 · DOI
Cited by
Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationEmerging roles of oxidative stress in brain aging and Alzheimer's disease
Ionescu-Tucker, A., & Cotman, C. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.014 · Cited by 737
Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches
Mary, A., Eysert, F., Checler, F., & Chami, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01631-6 · Cited by 244
Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease
McDaid, J., Mustaly-Kalimi, S., & Stutzmann, G. E. (2020) · Cells · doi:10.3390/cells9122655 · Cited by 73
Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases
Li, X., Huang, L., Lan, J., Feng, X., Li, P., Wu, L., & Peng, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105240 · Cited by 57
Metadata
- Authors
- Martín-Maestro, P., Gargini, R., Perry, G., Avila, J., & García-Escudero, V.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-12-31
- Volume
- 25
- Issue
- 4
- Pages
- 792-806
- ISSN
- 0964-6906
- 1460-2083
- Cited by
- 184
- References
- 10
- Language
- en
- Funders
- Ministerio de Economía y Competitividad (24841, BES-2012-055068)
- National Institute on Minority Health and Health Disparities (G12-MD007591)
- National Institutes of Health
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
