The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hormonal control of regional fat distribution
Abstract
Hormones exert powerful influences on body fat distribution in humans. Studies under fully controlled conditions in vitro have indicated that cortisol and insulin facilitate lipid accumulation by expressing lipoprotein lipase (LPL). Growth hormone (GH) abolishes this and turns metabolism towards lipid mobilization. Testosterone and GH inhibit LPL and stimulate lipolysis markedly. Cortisol effects are mediated via a glucocorticoid receptor, and testosterone effects via an androgen receptor, the density of which appears to be higher in visceral than subcutaneous adipose tissue. The receptor-mediated effects are probably expressed via transcription of appropriate genes. The female sex steroids also regulate adipose tissue metabolism, but apparently not directly in the absence of specific cellular receptors. Oestrogens seem to exert net effects similar to those of testosterone. These results of cellular studies agree well with in-vivo studies of triglyceride uptake and turnover in different adipose tissue regions. Furthermore, clinical entities with characteristic disturbances in hormone levels show the expected redistribution patterns.
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Cites
Androgen Treatment of Abdominally Obese Men
Mårin, P., Holmtäng, S., Gustafsson, C., Jönsson, ‡., Kvist, ‡., Elander, A., Eldh, J., Sjöström, L., Holm, G., & Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00618.x · Cited by 345
Self-citationMårin, P., Odén, B., & Björntorp, P. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829619 · Cited by 332 · cited 1×
“Upon administration of testosterone to slightly hypogonadal men, this difference is exaggerated ( Marin et al, 1995, 1996 ).”
BackgroundSelf-citationMårin, P., Lönn, L., Andersson, B., Odén, B., Olbe, L., Bengtsson, B. A., & Björntorp, P. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772568 · Cited by 172
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Cited by
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 741
Hak, A. E., Stehouwer, C. D. A., Bots, M. L., Polderman, K. H., Schalkwijk, C. G., Westendorp, I. C. D., Hofman, A., & Witteman, J. C. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.8.1986 · Cited by 525
Gender differences in cardiovascular disease
Gao, Z., Chen, Z., Sun, A., & Deng, X. (2019) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2019.100025 · Cited by 373
Central effects of estradiol in the regulation of food intake, body weight, and adiposity
Brown, L. M., & Clegg, D. J. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.005 · Cited by 331
Sexual differences in the control of energy homeostasis
Shi, H., Seeley, R. J., & Clegg, D. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.004 · Cited by 242
“Specifically, adipose tissue distributed in the abdominal or visceral region carries a much greater risk for metabolic disorders, than does adipose tissue distributed subcutaneously [19], [20] and [21].”
Background
Metadata
- Authors
- Bjorntorp, P.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-10-01
- Volume
- 12
- Issue
- suppl 1
- Pages
- 21-25
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2111064917
- Cited by
- 171
- References
- 3
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
