Androgen Treatment of Abdominally Obese Men
Open accessAbstract
Middle‐aged men with abdominal obesity were treated in a double‐blind study with moderate doses of transdermal preparations of testosterone (T), dihydrotestosterone (DHT), or placebo. This resulted in moderately elevated T concentrations and marked decreases in follicle stimulating and luteinizing hormones in the group treated with T, while the DHT group showed elevated DHT, markedly lower T values, and less diminution of gonadotropin concentrations. In the group treated with T visceral fat mass decreased (measured by computerized tomography) without significant changes in other depot fat regions. Lean body mass did not change. In the group treated with T, glucose disposal rate, measured with the euglycemic hyperinsulinemic clamp method, was markedly augmented. Plasma triglycerides, cholesterol, and fasting blood glucose concentrations as well as diastolic blood pressure decreased. There were no such changes in the DHT or placebo treatment groups. The men treated with T reported increased well‐being and energy. In none of the groups did prostate volume, specific prostate antigen concentration, genitourinary history, or urinary flow measurement change. It is suggested that supplementation of abdominal obese men with moderate doses of T might have several beneficial effects. (OBESITY RESEARCH 1993;1:245–251)
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Serum triglycerides decrease after 4 weeks and after 3 months of testosterone treatment, with further decrease over 9 or 12 months.
“The decrease in serum triglycerides follows a similar pattern: after 4 weeks (38), after 3 months (35), and with further decrease over 9 months (41) or 12 months (43).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [41]
Diastolic blood pressure declines after 3-9 months of testosterone treatment, and in some studies systolic blood pressure also declines.
“In some studies a decline in diastolic blood pressure has been observed, after 3–9 months (22, 35, 41, 44) and in some studies in systolic blood pressure also (35, 44).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [41]
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- Authors
- Mårin, P., Holmtäng, S., Gustafsson, C., Jönsson, ‡., Kvist, ‡., Elander, A., Eldh, J., Sjöström, L., Holm, G., & Björntorp, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Mårin, Per
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 1993-07
- Volume
- 1
- Issue
- 4
- Pages
- 245-251
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2009810419
- Cited by
- 345
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 14 · 2016: 8 · 2015: 17 · 2014: 18 · 2013: 18 · 2012: 19
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- androgen therapy, abdominal obesity, testosterone, dihydrotestosterone, visceral fat, glucose disposal, insulin sensitivity, gonadotropins, blood pressure, lipid profile, middle-aged men, prostate volume
- MeSH terms
- Adult, Aged, Androgens, Blood Glucose, Blood Pressure, Body Composition, Body Weight, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, Type 2, Double-Blind Method, Glucose, Gonadotropins, Humans, Male, Middle Aged, Obesity, Placebos, Risk Factors, Sex Hormone-Binding Globulin, Dihydrotestosterone, Testosterone, Time Factors, Tomography, X-Ray Computed, Triglycerides, Prostate-Specific Antigen, Abdominal Fat, Lipid Metabolism
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