Calcium ionophore-induced acrosome reaction correlates with fertilization rates in vitro in patients with teratozoospermic semen
Abstract
The aim of this study was to determine the relationship between calcium ionophore A23187-induced acrosome reaction (AR) and sperm fertilizing ability. Semen samples remaining after preparation for standard IVF were studied in 109 patients who had sperm concentrations > or =20 x 10(6)/ml. Ionophore-induced AR was performed on motile spermatozoa selected by centrifugation on a Percoll gradient. Semen analysis was performed using standard methods. Patients with higher (>50%, n = 76) fertilization rates had significantly higher ionophore-induced AR than patients with lower ( or =15% were analysed separately, only sperm count and the percentage of spermatozoa with progressive motility in semen were significantly related to fertilization rates. In conclusion, ionophore-induced AR was significantly related to fertilization rates in vitro mainly in patients with teratozoospermic semen. Tests for ionophore-induced AR may provide additional information about sperm fertilizing ability but may not indicate specific defects of the physiological AR.
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Pathophysiological studies have shown sometimes controversial associations between sperm morphology and sperm competence (aptitude to undergo the acrosomal reaction, DNA integrity, chromatin condensation, etc.).
“Sperm morphology assessment has also been examined in numerous pathophysiological studies that have shown sometimes controversial associations between morphology and sperm competence (aptitude to undergo the acrosomal reaction, DNA integrity, chromatin condensation, etc.) [5, 6, 7, 8].”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [5]
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- Authors
- Liu, D. Y., & Baker, H. W.
- Affiliations
- Royal Women's Hospital (AU)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-04-01
- Volume
- 13
- Issue
- 4
- Pages
- 905-910
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2147798729
- Cited by
- 52
- References
- 41
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Society of Human Reproduction and Embryology
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- acrosome reaction, A23187, fertilization rate, teratozoospermia, sperm fertilizing capacity, sperm motility, sperm morphology, sperm count, in vitro fertilization
- MeSH terms
- Calcimycin, Female, Fertilization, Fertilization in Vitro, Humans, Infertility, Male, Ionophores, Male, Semen, Sperm-Ovum Interactions, Spermatozoa, Treatment Failure
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