Predictive value of abnormal sperm morphology in in vitro fertilization
Open accessAbstract
In patients with acceptable sperm count and motility, two patterns of abnormal morphology, judged with strict criteria, were identified and described. Patients with less than 4% normal forms and less than 30% morphology index (summation of normal and slightly amorphous forms) had a fertilization rate of 7.6% of the oocytes (P pattern, poor prognosis). Patients with normal morphology between 4 and 14% had a significantly better fertilization rate of 63.9% of the oocytes (P less than 0.0001). Cases with greater than 14% normal forms fertilized within the normal range for the laboratory. By evaluating sperm morphology with the proposed strict criteria, its predictive value in in vitro fertilization is enhanced.
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Kruger et al. reported that men with less than 4% sperm with normal morphology had a fertilization rate of 7.6% while those with normal morphology between 4% and 14% had a fertilization rate of 63.9%.
“The predictive value of morphological assessment by strict criteria during IVF was first highlighted by Kruger et al. who reported that men with less than 4% sperm with normal morphology had a fertilization rate of 7.6% while those with normal morphology between 4% and 14% had a fertilization rate of 63.9% (90).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [90]
Publications examining the impact of morphology on spontaneous pregnancy, intrauterine insemination, and in vitro fertilization reach varying conclusions.
“Despite efforts to standardize methodology for grading sperm morphology, publications examining the impact morphology on spontaneous pregnancy, intrauterine insemination, and in vitro fertilization reach varying conclusions (2, 3, 4, 5, 6, 7, 8, 9, 10).”
From Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria (2022) · cites this paper as [7]
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- Authors
- Kruger, T. F., Acosta, A. A., Simmons, K. F., Swanson, R. J., Matta, J. F., & Oehninger, S.
- Affiliations
- Eastern Virginia Medical School (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 49
- Issue
- 1
- Pages
- 112-117
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W26653565
- Cited by
- 1,159
- References
- 0
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 21 · 2023: 12 · 2022: 18 · 2021: 24 · 2020: 13 · 2019: 19 · 2018: 29 · 2017: 31 · 2016: 27 · 2015: 34 · 2014: 36 · 2013: 42 · 2012: 41
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- sperm morphology, abnormal sperm morphology, in vitro fertilization, fertilization rate, outcome prediction, male infertility, sperm count and motility
- MeSH terms
- Female, Fertilization in Vitro, Humans, Male, Oocytes, Ovulation Induction, Prognosis, Sperm Motility, Spermatozoa
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