The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF *
Abstract
Many retrospective studies have shown that hydrosalpinx is associated with poor in-vitro fertilization (IVF) outcome. The mechanism of the actual cause is not yet fully understood. A clinical practice of performing salpingectomy before IVF has developed, without any evidence from prospective trials. The aim of the present prospective randomized trial was to test if a salpingectomy prior to IVF was effective in terms of increased pregnancy rates. Patients with hydrosalpinx were randomized to either a laparoscopic salpingectomy or no intervention before IVF. A total of 204 patients was available for an intention-to-treat analysis and 192 actually started IVF. Clinical pregnancy rates per included patient were 36.6% in the salpingectomy group and 23.9% in the non-intervention group (not significant, P = 0.067) and the ensuing delivery rates were 28.6% and 16.3% (P = 0.045). The corresponding delivery rates per transfer cycle were 29.5% versus 17. 5% (not significant, P = 0.083). A subgroup analysis revealed significant differences in favour of salpingectomy, in implantation rates in patients with bilateral hydrosalpinges (25.6% versus 12.3%, P = 0.038) and in clinical pregnancy rates (45.7% versus 22.5%, P = 0.029) and delivery rates (40.0% versus 17.5%, P = 0.038) in patients with ultrasound visible hydrosalpinges. The delivery rate was increased 3.5-fold in patients with bilateral hydrosalpinges visible on ultrasound (P = 0.019).
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Cites
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
Practical Statistics for Medical Research.
Walter, S. D., & Altman, D. G. (1992) · Biometrics · doi:10.2307/2532320 · Cited by 11,668
Camus, E. (1999) · Human Reproduction · doi:10.1093/humrep/14.5.1243 · Cited by 307
Hydrosalpinges adversely affect markers of endometrial receptivity
Meyer, W. R., Castelbaum, A. J., Somkuti, S., Sagoskin, A. W., Doyle, M., Harris, J. E., & Lessey, B. A. (1997) · Human Reproduction · doi:10.1093/humrep/12.7.1393 · Cited by 280
Adverse effects of hydrosalpinx on pregnancy rates after in vitro fertilization–embryo transfer
Zeyneloglu, H. B., Arici, A., & Olive, D. L. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00200-3 · Cited by 265
Hydrosalpinx reduces in-vitro fertilization/embryo transfer pregnancy rates
Strandell, A., Waldenström, U., Nilsson, L., & Hamberger, L. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138606 · Cited by 230
Self-citationAndersen, A. N., Yue, Z., Meng, F. J., & Petersen, K. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138362 · Cited by 170
Mukherjee, T., Copperman, A. B., McCaffrey, C., Cook, C. A., Bustillo, M., & Obasaju, M. F. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58652-x · Cited by 148
Murray, D. L., Sagoskin, A. W., Widra, E. A., & Levy, M. J. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00447-0 · Cited by 110
Kassabji, M., Sims, J. A., Butler, L. M., & Muasher, S. J. (1994) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(94)90269-0 · Cited by 104
Cited by
Fertility and infertility: Definition and epidemiology
Vander Borght, M., & Wyns, C. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.03.012 · Cited by 2,278
Recurrent implantation failure: definition and management
Coughlan, C., Ledger, W., Wang, Q., Liu, F., Demirol, A., Gurgan, T., Cutting, R., Ong, K., Sallam, H., & Li, T. C. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.08.011 · Cited by 904
Investigation and treatment of repeated implantation failure following IVF-ET
Margalioth, E. J., Ben-Chetrit, A., Gal, M., & Eldar-Geva, T. (2006) · Human Reproduction · doi:10.1093/humrep/del305 · Cited by 472
Surgical treatment for tubal disease in women due to undergo in vitro fertilisation
Johnson, N., van Voorst, S., Sowter, M. C., Strandell, A., & Mol, B. W. J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002125.pub3 · Cited by 340
Self-citationHydrosalpinx fluid diminishes endometrial cell HOXA10 expression
Daftary, G. S., & Taylor, H. S. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03306-x · Cited by 78
Metadata
- Authors
- Strandell, A., Lindhard, A., Waldenström, U., Thorburn, J., Janson, P. O., & Hamberger, L.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11
- Volume
- 14
- Issue
- 11
- Pages
- 2762-2769
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2143020969
- Cited by
- 349
- References
- 18
- FWCI
- 15.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF *. https://app.cochat.ai/papers/10.1093/humrep/14.11.2762
- The paper
- Strandell, A., Lindhard, A., Waldenström, U., Thorburn, J., Janson, P. O., & Hamberger, L. (1999). Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF *. Human Reproduction. https://doi.org/10.1093/humrep/14.11.2762
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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