The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Study of apoptotic DNA fragmentation in human spermatozoa
Open accessAbstract
The aim of our work was to define and better understand apoptosis in the spermatozoa of normal subjects, infertile patients and patients affected by specific tumoral diseases employing the method of the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling and confirming the results by electron microscopy. We studied 23 healthy, normozoospermic subjects (group A), 29 oligoasthenoteratozoospermic patients, affected by various andrological pathologies (group B), 28 patients with Hodgkin's disease (C1) and 30 patients with testicular cancer (C2). Our data demonstrate that the percentage of apoptosis in normozoospermic subjects (group A) is significantly lower than in all the other groups (B, C1, C2) (P < 0.001). This confirms that high DNA fragmentation is one of the characteristics of spermatogenetic failure. The induction of apoptosis, which can also be a basic response to neoplastic disease, can even act right up to the mature male gamete. Our results suggest that apoptosis could be the final result of various pathologies and of a deregulation of spermatogenesis control systems.
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Cites
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Cited by
Bungum, M. (2004) · Human Reproduction · doi:10.1093/humrep/deh280 · Cited by 477
Male infertility testing: reactive oxygen species and antioxidant capacity
Ko, E. Y., Sabanegh, E. S., & Agarwal, A. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.10.020 · Cited by 329
Sperm chromatin structure and male fertility: biological and clinical aspects
Erenpreiss, J., Spano, M., Erenpreisa, J., Bungum, M., & Giwercman, A. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00112.x · Cited by 304
Benchaib, M., Lornage, J., Mazoyer, C., Lejeune, H., Salle, B., & François Guerin, J. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.057 · Cited by 285
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Metadata
- Authors
- Gandini, L.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-04-01
- Volume
- 15
- Issue
- 4
- Pages
- 830-839
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1991270389
- Cited by
- 311
- References
- 28
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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