The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI
Abstract
INTRODUCTION: Sperm chromatin integrity assessment has been suggested as a fertility predictor. The aim of this study was to examine the relationship between the results of sperm chromatin structure assay (SCSA) and the outcome of IVF, ICSI and intrauterine insemination (IUI). METHODS: A total of 306 consecutive couples undergoing assisted reproduction were included. IUI was performed in 131, IVF in 109 and ICSI in 66. SCSA results were expressed as DNA fractionation index (DFI) and highly DNA stainable (HDS) cell fractions. Reproductive outcome parameters were biochemical pregnancy (BP), clinical pregnancy (CP) and delivery (D). RESULTS: For IUI, the chance of pregnancy/delivery was significantly higher in the group with DFI 27% or HDS >10%. The odds ratios (ORs) (95% confidence intervals) were 20 (2.3-117), 16 (1.9-137) and 14 (1.6-110) for BP, CP and D, respectively. No statistical difference between the outcomes of IVF versus ICSI was observed in the group with DFI 27% group, however, the results of ICSI were significantly better than those of IVF. Comparing ICSI with IVF, the OR (95% CI) for BP was 26 (1.9-350). CONCLUSIONS: SCSA is a useful method for prediction of the outcome of assisted reproduction.
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Evenson, D. P. (1999) · Human Reproduction · doi:10.1093/humrep/14.4.1039 · Cited by 1,121
The Risk of Major Birth Defects after Intracytoplasmic Sperm Injection and in Vitro Fertilization
Hansen, M., Kurinczuk, J. J., Bower, C., & Webb, S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010035 · Cited by 1,083
EVENSON, D. P., LARSON, K. L., & JOST, L. K. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02599.x · Cited by 1,072 · cited 6×
“We have expressed the extent of DNA denaturation in terms of the DFI, which is the ratio of red to total (red plus green) ¯uorescence intensity, i.e. the level of denatured DNA over the total DNA (Evenson et al., 2002).”
BackgroundMethodResultInfluentialDeBaun, M. R., Niemitz, E. L., & Feinberg, A. P. (2003) · The American Journal of Human Genetics · doi:10.1086/346031 · Cited by 916
Role of sperm chromatin abnormalities and DNA damage in male infertility
Agarwal, A. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg027 · Cited by 857
Relation of Mammalian Sperm Chromatin Heterogeneity to Fertility
Evenson, D. P., Darzynkiewicz, Z., & Melamed, M. R. (1980) · Science · doi:10.1126/science.7444440 · Cited by 812
DNA Integrity in Human Spermatozoa: Relationships With Semen Quality
IRVINE, D. S., TWIGG, J. P., GORDON, E. L., FULTON, N., MILNE, P. A., & AITKEN, R. J. (2000) · Journal of Andrology · doi:10.1002/j.1939-4640.2000.tb03273.x · Cited by 736
Oxidative stress, DNA damage and the Y chromosome
Aitken, R. J., & Krausz, C. (2001) · Reproduction · doi:10.1530/rep.0.1220497 · Cited by 730
Sperm chromatin damage impairs human fertility
Spanò, M., Bonde, J. P., Hjøllund, H. I., Kolstad, H. A., Cordelli, E., & Leter, G. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00462-8 · Cited by 719
Intracytoplasmic Sperm Injection May Increase the Risk of Imprinting Defects
Cox, G. F., Bürger, J., Lip, V., Mau, U. A., Sperling, K., Wu, B.-L., & Horsthemke, B. (2002) · The American Journal of Human Genetics · doi:10.1086/341096 · Cited by 704
Cited by
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., Kirkman-Brown, J., & Coomarasamy, A. (2012) · Human Reproduction · doi:10.1093/humrep/des261 · Cited by 629
Origins and consequences of DNA damage in male germ cells
Aitken, R. J., & De Iuliis, G. N. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60676-1 · Cited by 425
De Iuliis, G. N., Thomson, L. K., Mitchell, L. A., Finnie, J. M., Koppers, A. J., Hedges, A., Nixon, B., & Aitken, R. J. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.076836 · Cited by 419
Carrell, D., Simon, L., Zini, A., Dyachenko, A., & Ciampi, A. (2017) · Asian Journal of Andrology · doi:10.4103/1008-682x.182822 · Cited by 409
Zhao, J., Zhang, Q., Wang, Y., & Li, Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.033 · Cited by 361
Metadata
- Authors
- Bungum, M.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-04-22
- Volume
- 19
- Issue
- 6
- Pages
- 1401-1408
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2122407132
- Cited by
- 477
- References
- 50
- FWCI
- 27.03
- Type
- journal article
- Language
- en
- Open access
- closed
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