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Mitochondrial distribution and function in oocytes and early embryos
Abstract
Active mitochondria relocate during oocyte maturation or fertilization in several species. Detailed studies with hamster oocytes and early embryos reveal a pattern of active mitochondria migrating to surround the pronuclei to form a pattern that persists through the early cleavage stages. Although the functional significance of this relocation is unknown, it appears to be an important part of normal development in hamsters. Treatments that disrupt embryo development in vitro (such as the presence of inorganic phosphate or alteration of intracellular pH) also disrupt the normal pattern of mitochondrial distribution. Active mitochondria also reorganize during maturation in bovine oocytes and during fertilization in rhesus monkey oocytes. Examination of these changes in mitochondrial organization may provide insights into the regulation of normal embryo development and might serve as predictors of oocyte or embryo developmental competence.
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Cited by
Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos
Wilding, M., Dale, B., Marino, M., di Matteo, L., Alviggi, C., Pisaturo, M. L., Lombardi, L., & De Placido, G. (2001) · Human Reproduction · doi:10.1093/humrep/16.5.909 · Cited by 531
Ramalho-Santos, J., Varum, S., Amaral, S., Mota, P. C., Sousa, A. P., & Amaral, A. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp016 · Cited by 482
Role of Fatty Acids in Energy Provision During Oocyte Maturation and Early Embryo Development
Sturmey, R., Reis, A., Leese, H., & McEvoy, T. (2009) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2009.01402.x · Cited by 398
Evaluation of oocyte quality: morphological, cellular and molecular predictors
Wang, Q., & Sun, Q.-Y. (2006) · Reproduction, Fertility and Development · doi:10.1071/rd06103 · Cited by 306
Yu, Y., Dumollard, R., Rossbach, A., Lai, F. A., & Swann, K. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22171 · Cited by 254
Metadata
- Authors
- Bavister, B. D., & Squirrell, J. M.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-07-01
- Volume
- 15
- Issue
- suppl 2
- Pages
- 189-198
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2088048329
- Cited by
- 283
- References
- 0
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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