The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Role of Fatty Acids in Energy Provision During Oocyte Maturation and Early Embryo Development
Abstract
Contents: While much is known about the metabolism of exogenous nutrients such as glucose, lactate, pyruvate, amino acids by oocytes and pre‐implantation mammalian embryos, the role of endogenous stores, particularly lipid, has been largely overlooked. The presence of lipid within oocytes and early embryos has been long known, and comparisons between species indicate that the amounts and types of lipid present vary considerably. Large amounts of intracellular lipid can compromise the success of cryopreservation and the removal of such lipid has been the subject of considerable effort. In this review, we present evidence that strongly suggests a metabolic role for lipid, specifically with regard to energy provision, in the late‐stage oocyte and the pre‐implantation embryo. We focus initially on oxygen consumption as a global indicator of metabolic activity, before reviewing different approaches that either have been designed to investigate directly, or have revealed indirectly the role of endogenous lipid in energy generation. These fall under five headings: (i) fatty acid oxidation; (ii) inhibition of triglyceride oxidation; (iii) culture in the absence of exogenous substrates; (iv) cytoplasmic organization; and (v) delipidation. On the basis of the data derived from these studies, we conclude that there is strong evidence for the utilization of endogenous lipid as an energy substrate by oocytes and early embryos.
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Cites
Brasaemle, D. L. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700014-jlr200 · Cited by 992
Stojkovic, M., Machado, S. A., Stojkovic, P., Zakhartchenko, V., Hutzler, P., Gonçalves, P. B., & Wolf, E. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.3.904 · Cited by 530
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Self-citationQuiet please, do not disturb: a hypothesis of embryo metabolism and viability
Leese, H. J. (2002) · BioEssays · doi:10.1002/bies.10137 · Cited by 403
Self-citationOxygen consumption and energy metabolism of the early mouse embryo
Houghton, F. D., Thompson, J. G., Kennedy, C. J., & Leese, H. J. (1996) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199608)44:4<476::aid-mrd7>3.0.co;2-i · Cited by 352
Self-citationOxygen uptake and carbohydrate metabolism by in vitro derived bovine embryos
Thompson, J. G., Partridge, R. J., Houghton, F. D., Cox, C. I., & Leese, H. J. (1996) · Reproduction · doi:10.1530/jrf.0.1060299 · Cited by 335
Self-citationSun, Q. Y., Wu, G. M., Lai, L., Park, K. W., Cabot, R., Cheong, H. T., Day, B. N., Prather, R. S., & Schatten, H. (2001) · Reproduction · doi:10.1530/rep.0.1220155 · Cited by 299
Mitochondrial distribution and function in oocytes and early embryos
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Metabolism of the viable mammalian embryo: quietness revisited
Leese, H. J., Baumann, C. G., Brison, D. R., McEvoy, T. G., & Sturmey, R. G. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan065 · Cited by 267
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Cited by
Current progress in oocyte and embryo cryopreservation by slow freezing and vitrification
Saragusty, J., & Arav, A. (2011) · Reproduction · doi:10.1530/rep-10-0236 · Cited by 494
Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation
Dunning, K. R., Russell, D. L., & Robker, R. L. (2014) · Reproduction · doi:10.1530/rep-13-0251 · Cited by 451
Autophagy in Ovarian Follicular Development and Atresia
Zhou, J., Peng, X., & Mei, S. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.30369 · Cited by 304
Diet and female fertility: doctor, what should I eat?
Chiu, Y.-H., Chavarro, J. E., & Souter, I. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.05.027 · Cited by 91
Kazemi, M., Jarrett, B. Y., Vanden Brink, H., Lin, A. W., Hoeger, K. M., Spandorfer, S. D., & Lujan, M. E. (2020) · Nutrients · doi:10.3390/nu12071953 · Cited by 53
Metadata
- Authors
- Sturmey, R., Reis, A., Leese, H., & McEvoy, T.
- Venue
- Reproduction in Domestic Animals
- Publisher
- Wiley
- Published
- 2009-07-22
- Volume
- 44
- Issue
- s3
- Pages
- 50-58
- ISSN
- 0044-5371 (ISSN-L)
- 0936-6768
- 1439-0531
- OpenAlex
- W2125161176
- Cited by
- 398
- References
- 32
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Role of Fatty Acids in Energy Provision During Oocyte Maturation and Early Embryo Development. https://app.cochat.ai/papers/10.1111/j.1439-0531.2009.01402.x
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- Sturmey, R., Reis, A., Leese, H., & McEvoy, T. (2009). Role of Fatty Acids in Energy Provision During Oocyte Maturation and Early Embryo Development. Reproduction in Domestic Animals. https://doi.org/10.1111/j.1439-0531.2009.01402.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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