The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol
Abstract
A novel contraceptive vaginal ring releasing etonogestrel 120 microg and ethinyl oestradiol 15 microg daily over a period of 3 weeks was tested. Each ring was used for one cycle, comprising 3 weeks of ring use followed by a 1 week ring-free period. This 1 year, multicentre study assessed the contraceptive efficacy, cycle control, tolerability and acceptability of the contraceptive. Altogether, 1145 women were exposed to the vaginal ring for 12,109 cycles (928 woman-years). Six pregnancies occurred during treatment, giving a Pearl Index of 0.65 (95% confidence interval 0.24--1.41). Cycle control was very good, since irregular bleeding was rare (2.6--6.4% of evaluable cycles) and withdrawal bleeding (mean duration 4.7--5.3 days) occurred in 97.9--99.4% of evaluable cycles. Compliance to the prescribed regimen was high with criteria being fulfilled in 90.8% of cycles. The ring was well tolerated. The majority of women considered this new contraceptive method easy to use, and it offers an effective, convenient, well-accepted and novel method for hormonal contraception.
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Cites
Timmer, C. J., & Mulders, T. M. T. (2000) · Clinical Pharmacokinetics · doi:10.2165/00003088-200039030-00005 · Cited by 259
Self-citationClassification and comparison of oral contraceptives containing new generation progestogens
Newton (1995) · Human Reproduction Update · doi:10.1093/humupd/1.3.231 · Cited by 57
Fotherby, K. (1995) · Contraception · doi:10.1016/0010-7824(94)00010-t · Cited by 54
Efficacy, bleeding patterns, and side effects of a 1-year contraceptive vaginal ring
Weisberg, E., Fraser, I. S., Lacarra, M., Mishell, D. R., Alvarez, F., Brache, V, & Nash, H. A. (1999) · Contraception · doi:10.1016/s0010-7824(99)00035-9 · Cited by 43
Endrikat, J., Jaques, M.-A., Mayerhofer, M., et al. (1995) · Contraception · doi:10.1016/0010-7824(95)00191-c · Cited by 35
Serfaty, D., & Vree, M. L. (1998) · The European Journal of Contraception & Reproductive Health Care · doi:10.3109/13625189809167251 · Cited by 33
A contraceptive vaginal ring releasing norethindrone acetate and ethinyl estradiol
Ballagh, S. A., Mishell, D. R., Lacarra, M., Shoupe, D., Jackanicz, T. M., & Eggena, P. (1994) · Contraception · doi:10.1016/0010-7824(94)90011-6 · Cited by 30
Cited by
Ott, M. A., Sucato, G. S., COMMITTEE ON ADOLESCENCE, Braverman, P. K., Adelman, W. P., Alderman, E. M., Breuner, C. C., Levine, D. A., Marcell, A. V., & O’Brien, R. F. (2014) · PEDIATRICS · doi:10.1542/peds.2014-2300 · Cited by 402
History of oral contraceptive drugs and their use worldwide
Christin-Maitre, S. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.11.004 · Cited by 272
Why consider vaginal drug administration?
Alexander, N. J., Baker, E., Kaptein, M., Karck, U., Miller, L., & Zampaglione, E. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.01.025 · Cited by 269
Advances in the management of endometriosis: an update for clinicians
Crosignani, P., Olive, D., Bergqvist, A., & Luciano, A. (2006) · Human Reproduction Update · doi:10.1093/humupd/dmi049 · Cited by 237
Wearable and implantable devices for drug delivery: Applications and challenges
Kar, A., Ahamad, N., Dewani, M., Awasthi, L., Patil, R., & Banerjee, R. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121435 · Cited by 179
Metadata
- Authors
- Roumen, F. J. M. E., Apter, D., Mulders, T. M. T., & Dieben, T. O. M.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-03-01
- Volume
- 16
- Issue
- 3
- Pages
- 469-475
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2151939658
- Cited by
- 264
- References
- 7
- FWCI
- 17.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Roumen, F. J. M. E., Apter, D., Mulders, T. M. T., & Dieben, T. O. M. (2001). Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol. Human Reproduction. https://doi.org/10.1093/humrep/16.3.469
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
