The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The role of genetic factors in age at natural menopause
Open accessAbstract
BACKGROUND: Environmental factors explain only a small part of the age variance at which menopause commences. The variation in natural menopause is a trait predominantly determined by interaction of multiple genes, whose identity and causative genetic variation remains to be determined. Menopause is a retrospective marker for the reproductive capacity of preceding years, since subfertility and infertility precede menopause at distinct time-intervals. In the present study we have investigated the contribution of genetic factors to menopausal age. METHODS: Data were collected from a random population sample of singleton and twin sisters participating in a prospective breast cancer screening project, who had subsequently experienced natural menopause. Heritability of menopausal age was estimated with analysis of variance, Mx modelling and Gibbs sampling. RESULTS: All produced almost identical heritability estimates of 0.85-0.87 for singleton sisters, suggesting a strong genetic contribution to menopausal age. Twin data were used to distinguish additive genetic from common environmental effects; a heritability of 0.71-0.72 was determined, which does not deviate significantly from the estimate for singleton sisters. CONCLUSIONS: According to our findings, a woman with a family history of early menopause risks early menopause and consequently early reproductive failure herself.
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Sampling-based approaches to calculating marginal densities
Gelfand, A. E., & Smith, A. F. M. (1990) · Journal of the American Statistical Association · doi:10.1080/01621459.1990.10476213 · Cited by 6,606
XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
Fisher, R. A. (1919) · Transactions of the Royal Society of Edinburgh · doi:10.1017/s0080456800012163 · Cited by 4,387
Cited by
Ovarian aging: mechanisms and clinical consequences
Broekmans, F. J., Soules, M. R., & Fauser, B. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0006 · Cited by 1,248
The variability of female reproductive ageing
te Velde, E. R. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.2.141 · Cited by 1,214
Self-citationFemale reproductive ageing: current knowledge and future trends
Broekmans, F. J., Knauff, E. A. H., te Velde, E. R., Macklon, N. S., & Fauser, B. C. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.01.004 · Cited by 427
Self-citationFactors Related to Age at Natural Menopause: Longitudinal Analyses From SWAN
Gold, E. B., Crawford, S. L., Avis, N. E., Crandall, C. J., Matthews, K. A., Waetjen, L. E., Lee, J. S., Thurston, R., Vuga, M., & Harlow, S. D. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws421 · Cited by 429
Premature menopause in a multi-ethnic population study of the menopause transition
Luborsky, J. L., Meyer, P., Sowers, M. F., Gold, E. B., & Santoro, N. (2003) · Human Reproduction · doi:10.1093/humrep/deg005 · Cited by 423
Metadata
- Authors
- de Bruin, J. P., Bovenhuis, H., van Noord, P. A. H., Pearson, P. L., van Arendonk, J. A. M., te Velde, E. R., Kuurman, W. W., & Dorland, M.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09
- Volume
- 16
- Issue
- 9
- Pages
- 2014-2018
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2142534216
- Cited by
- 301
- References
- 2
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- de Bruin, J. P., Bovenhuis, H., van Noord, P. A. H., Pearson, P. L., van Arendonk, J. A. M., te Velde, E. R., Kuurman, W. W., & Dorland, M. (2001). The role of genetic factors in age at natural menopause. Human Reproduction. https://doi.org/10.1093/humrep/16.9.2014
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