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Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique
Abstract
BACKGROUND: Standard sperm characteristics are poor predictors of the outcome of IVF treatments. On the contrary, sperm genome quality has been emphasized for several years as playing a major role in early embryogenesis, thus in the success of IVF attempt. METHODS: Sperm DNA fragmentation from a selected group of 104 couples undergoing assisted reproductive techniques (ART) (IVF: n = 50; and ICSI: n = 54) was measured by TUNEL assay and correlated with semen and ART outcomes. RESULTS: A negative correlation was found between sperm characteristics and the proportion of sperm showing DNA fragmentation. For fragmentation >10%, a significant decrease of the fertilization rate was observed. No correlation was found between sperm DNA fragmentation and embryo quality. A high proportion of sperm with fragmented DNA was a pejorative factor to obtain pregnancies when ICSI was performed, but there was no relationship when conventional IVF was performed. CONCLUSIONS: The proportion of sperm with DNA fragmentation appears to be potentially useful as a predictor of ICSI outcome, whereas embryo quality based on morphological criteria, appeared unaffected by DNA fragmentation.
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Cited by
Reduction of the Incidence of Sperm DNA Fragmentation by Oral Antioxidant Treatment
Greco, E., Iacobelli, M., Rienzi, L., Ubaldi, F., Ferrero, S., & Tesarik, J. (2005) · Journal of Andrology · doi:10.2164/jandrol.04146 · Cited by 511
Bungum, M. (2004) · Human Reproduction · doi:10.1093/humrep/deh280 · Cited by 477
Tesarik, J. (2004) · Human Reproduction · doi:10.1093/humrep/deh127 · Cited by 454
Sharma, R., Agarwal, A., Rohra, V. K., Assidi, M., Abu-Elmagd, M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 451
Origins and consequences of DNA damage in male germ cells
Aitken, R. J., & De Iuliis, G. N. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60676-1 · Cited by 425
Metadata
- Authors
- Benchaib, M.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-05-01
- Volume
- 18
- Issue
- 5
- Pages
- 1023-1028
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2097286099
- Cited by
- 463
- References
- 0
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- closed
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