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Reduction of the Incidence of Sperm DNA Fragmentation by Oral Antioxidant Treatment
Open accessAbstract
ABSTRACT: Sperm DNA fragmentation is known to compromise male fertility. Previous findings have suggested the implication of oxidative stress in the etiology of this pathological condition. The present study was conducted to find out if the pathologically increased incidence of DNA fragmentation in ejaculated spermatozoa can be reduced by oral treatment with two antioxidants, vitamins C and E. Sixty‐four men with unexplained infertility and an elevated (≥15%) percentage of DNA‐fragmented spermatozoa in the ejaculate were randomized between an antioxidant treatment (1 g vitamin C and 1 g vitamin E daily for 2 months) group and a placebo group. Sperm DNA fragmentation was evaluated by terminal deoxyribonucleotidyl transferase‐mediated dUTP nick‐end labeling assay before and after treatment. No differences in basic sperm parameters were found between the antioxidant treatment and the placebo group before or after treatment. However, the percentage of DNA‐fragmented spermatozoa was markedly reduced (P < .001) in the antioxidant treatment group after the treatment (9.1 ± 7.2) as compared with the pretreatment values (22.1 ± 7.7). No difference in the pretreatment and posttreatment incidence of sperm DNA fragmentation was observed in the placebo group. These data show that sperm DNA damage can be efficiently treated with oral antioxidants administered during a relatively short time period.
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Citations
Cited by
Male infertility testing: reactive oxygen species and antioxidant capacity
Ko, E. Y., Sabanegh, E. S., & Agarwal, A. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.10.020 · Cited by 329
Antioxidants for male subfertility
Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub3 · Cited by 285
Benchaib, M., Lornage, J., Mazoyer, C., Lejeune, H., Salle, B., & François Guerin, J. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.057 · Cited by 285
Antioxidants for male subfertility
Smits, R. M., Mackenzie-Proctor, R., Yazdani, A., Stankiewicz, M. T., Jordan, V., & Showell, M. G. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub4 · Cited by 277
Role of antioxidants in the treatment of male infertility
Kefer, J. C., Agarwal, A., & Sabanegh, E. (2009) · International Journal of Urology · doi:10.1111/j.1442-2042.2009.02280.x · Cited by 273
Metadata
- Authors
- Greco, E., Iacobelli, M., Rienzi, L., Ubaldi, F., Ferrero, S., & Tesarik, J.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 2005-05-06
- Volume
- 26
- Issue
- 3
- Pages
- 349-353
- ISSN
- 0196-3635 (ISSN-L)
- 1939-4640
- OpenAlex
- W2052999816
- Cited by
- 511
- References
- 0
- FWCI
- 17.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Greco, E., Iacobelli, M., Rienzi, L., Ubaldi, F., Ferrero, S., & Tesarik, J. (2005). Reduction of the Incidence of Sperm DNA Fragmentation by Oral Antioxidant Treatment. Journal of Andrology. https://doi.org/10.2164/jandrol.04146
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