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Cited by 43Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

Is insulin resistance an essential component of PCOS?: The influence of confounding factors

Cibula, D.·2004·Human Reproduction
DOI 10.1093/humrep/deh137
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Abstract

Insulin resistance is often considered a regular component of polycystic ovary syndrome (PCOS). Many interventional studies assume a state of insulin resistance in all patients. However, the evidence is based on small samples that are often insufficient to adjust for significant confounding factors. Moreover, several studies have not confirmed differences in insulin sensitivity between women with PCOS and healthy controls, especially in non-obese patients. This debate article provides an overview of the data published regarding the presence of abnormal or normal insulin sensitivity in PCOS. In conclusion, available data offer evidence that a substantial subgroup of women with PCOS have insulin sensitivity comparable with healthy controls if matched carefully for potential confounding factors.

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Authors
Cibula, D.
Affiliations
Charles University (CZ)
Corresponding author
Cibula, D.
ORCID
Cibula, D.
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2004-02-12
Volume
19
Issue
4
Pages
757-759
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/deh137
OpenAlex
W2096281233
Cited by
43
References
0
Citations by year
2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 1 · 2017: 1 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
4.90
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministerstvo Zdravotnictví Ceské Republiky
  • National Institutes of Health (NH/6558-3)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
polycystic ovary syndrome, insulin resistance, insulin sensitivity, confounding factors, obesity, non-obese women, subgroup analysis
MeSH terms
Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome

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