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Cited by 364

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception

Bonduelle, M., Wennerholm, U.-B., Loft, A., Tarlatzis, B.C., Peters, C., Henriet, S., Mau, C., Victorin-Cederquist, A., Van Steirteghem, A., Balaska, A., Emberson, J.R., Sutcliffe, A.G.·2005·Human Reproduction
DOI 10.1093/humrep/deh592
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Abstract

BACKGROUND: Over a million children have been born from assisted conception worldwide. Newer techniques being introduced appear less and less 'natural', such as intracytoplasmic sperm injection (ICSI), but there is little information on these children beyond the neonatal period. METHODS: 540 ICSI conceived 5-year-old children from five European countries were comprehensively assessed, along with 538 matched naturally conceived children and 437 children conceived with standard IVF. RESULTS: Of the 540 ICSI children examined, 63 (4.2%) had experienced a major congenital malformation. Compared with naturally conceived children, the odds of a major malformation were 2.77 (95% CI 1.41-5.46) for ICSI children and 1.80 (95% CI 0.85-3.81) for IVF children; these estimates were little affected by adjustment for socio-demographic factors. The higher rate observed in the ICSI group was due partially to an excess of malformations in the (boys') urogenital system. In addition, ICSI and IVF children were more likely than naturally conceived children to have had a significant childhood illness, to have had a surgical operation, to require medical therapy and to be admitted to hospital. A detailed physical examination revealed no further substantial differences between the groups, however. CONCLUSIONS: Singleton ICSI and IVF 5-year-olds are more likely to need health care resources than naturally conceived children. Assessment of singleton ICSI and IVF children at 5 years of age was generally reassuring, however, we found that ICSI children presented with more major congenital malformations and both ICSI and IVF children were more likely to need health care resources than naturally conceived children. Ongoing monitoring of these children is therefore required.

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Metadata

Authors
Bonduelle, M., Wennerholm, U.-B., Loft, A., Tarlatzis, B. C., Peters, C., Henriet, S., Mau, C., Victorin-Cederquist, A., Van Steirteghem, A., Balaska, A., Emberson, J. R., & Sutcliffe, A. G.
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2005-02-01
Volume
20
Issue
2
Pages
413-419
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/deh592
OpenAlex
W2129259025
Cited by
364
References
19
FWCI
21.82
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. https://app.cochat.ai/papers/10.1093/humrep/deh592
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Bonduelle, M., Wennerholm, U.-B., Loft, A., Tarlatzis, B. C., Peters, C., Henriet, S., Mau, C., Victorin-Cederquist, A., Van Steirteghem, A., Balaska, A., Emberson, J. R., & Sutcliffe, A. G. (2005). A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Human Reproduction. https://doi.org/10.1093/humrep/deh592

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.