The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Incidence of congenital malformations in children born after ICSI
Abstract
The aim of this study was to determine the incidence of congenital malformations in a complete cohort of children born after intracytoplasmic sperm injection (ICSI). The medical records were retrieved for 1139 infants, 736 singletons, 200 sets of twins and one set of triplets. The total number of infants with an identified anomaly was 87 (7.6%), 40 of which were minor. The incidence of malformations in children born after ICSI was also compared with all births in Sweden using data from the Swedish Medical Birth Registry and the Registry of Congenital Malformations. For ICSI children, the odds ratio (OR) for having any major or minor malformation was 1.75 [95% confidence interval (CI) 1.19-2.58] after stratification for delivery hospital, year of birth and maternal age. If stratification for singletons/twins was also done, the OR was reduced to 1.19 (95% CI 0.79-1.81). The increased rate of congenital malformations is thus mainly a result of a high rate of multiple births. The only specific malformation which was found to occur in excess in children born after ICSI was hypospadias (relative risk 3.0, exact 95% CI 1. 09-6.50) which may be related to paternal subfertility.
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The Risk of Major Birth Defects after Intracytoplasmic Sperm Injection and in Vitro Fertilization
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Assisted reproductive technology and major structural birth defects in the United States
Reefhuis, J., Honein, M. A., Schieve, L. A., Correa, A., Hobbs, C. A., Rasmussen, S. A., & Study, T. N. B. D. P. (2009) · Human Reproduction · doi:10.1093/humrep/den387 · Cited by 306
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Heredity of hypospadias and the significance of low birth weight
FREDELL, L., KOCKUM, I., HANSSON, E., HOLMNER, S., LUNDQUIST, L., LÄCKGREN, G., PEDERSEN, J., STENBERG, A., WESTBACKE, G., & NORDENSKJÖLD, A. (2002) · Journal of Urology · doi:10.1016/s0022-5347(05)65334-7 · Cited by 157
Metadata
- Authors
- Wennerholm, U.-B.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-04-01
- Volume
- 15
- Issue
- 4
- Pages
- 944-948
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2100619372
- Cited by
- 355
- References
- 14
- FWCI
- 25.03
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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