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Cited by 200Ovarian function and disordersAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study

Escobar-Morreale, H.F.·2006·Human Reproduction
DOI 10.1093/humrep/del146
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Abstract

BACKGROUND: We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS). METHODS: Seventy-six PCOS patients and 40 non-hyperandrogenic women matched for BMI and degree of obesity were included. Serum adiponectin and resistin levels, anthropometrical and hormonal variables, the 45 T-->G and 276 G-->T polymorphisms in the adiponectin gene, and the -420 C-->G variant in the resistin gene, were analysed. RESULTS: Serum adiponectin concentrations were reduced in PCOS patients compared with controls (P = 0.038) irrespective of the degree of obesity, whereas serum resistin levels were increased in overweight and obese women compared with lean subjects (P = 0.016), irrespective of their PCOS or controls status. The adiponectin and resistin polymorphisms were not associated with PCOS and did not influence serum levels of adiponectin, resistin and other clinical and hormonal variables. In a multiple regression model, the waist-to-hip ratio, free testosterone levels and age, but not insulin resistance, were the major determinants of hypoadiponectinaemia. CONCLUSIONS: PCOS patients present with hypoadiponectinaemia, in relation with abdominal adiposity and hyperandrogenism. Our present results suggest that hyperandrogenism and abdominal obesity, by reducing the serum levels of the insulin sensitizer adipokine adiponectin, might contribute to the insulin resistance of PCOS.

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Crossref · 10.1093/humrep/del146

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Metadata

Authors
Escobar-Morreale, H. F.
Affiliations
Hospital Universitario Ramón y Cajal (ES)
Corresponding author
Escobar-Morreale, H.F.
ORCID
Escobar-Morreale, H.F.
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2006-06-03
Volume
21
Issue
9
Pages
2257-2265
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/del146
OpenAlex
W2129639179
Cited by
200
References
51
Citations by year
2026: 4 · 2025: 3 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 6 · 2019: 6 · 2018: 13 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 15 · 2013: 12 · 2012: 19
FWCI
13.76
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Comunidad de Madrid
  • Instituto de Salud Carlos III
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, adiponectin, resistin, hyperandrogenism, abdominal obesity, waist-to-hip ratio, free testosterone, insulin resistance, adiponectin gene polymorphism, adipokines
MeSH terms
Adult, Blood Pressure, Cross-Sectional Studies, Female, Genotype, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Polymorphism, Genetic, Case-Control Studies, Adiponectin, Resistin

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