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The causes of misdiagnosis and adverse outcomes in PGD
Abstract
The European Society of Human Reproduction and Embryology PGD Consortium has collected data on PGD cycles and deliveries since 1997. From 15,158 cycles, 24 misdiagnoses and adverse outcomes have been reported; 12/2538 cycles after polymerase chain reaction and 12/12,620 cycles after fluorescence in situ hybridization. The causes of misdiagnosis include confusion of embryo and cell number, transfer of the wrong embryo, maternal or paternal contamination, allele dropout, use of incorrect and inappropriate probes or primers, probe or primer failure and chromosomal mosaicism. Unprotected sex has been mentioned as a cause of adverse outcome not related to technical and human errors. The majority of these causes can be prevented by using robust diagnostic methods within laboratories working to appropriate quality standards. However, diagnosis from a single cell remains a technically challenging procedure, and the risk of misdiagnosis cannot be eliminated.
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Cited by
The ESHRE PGD Consortium: 10 years of data collection
Harper, J. C., Wilton, L., Traeger-Synodinos, J., Goossens, V., Moutou, C., SenGupta, S. B., Pehlivan Budak, T., Renwick, P., De Rycke, M., Geraedts, J. P. M., et al. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr052 · Cited by 299
Self-citationPreimplantation genetic diagnosis at 20 years
Simpson, J. L. (2010) · Prenatal Diagnosis · doi:10.1002/pd.2552 · Cited by 117
PREIMPLANTATION GENETIC TESTING: clinical experience of preimplantation genetic testing
De Rycke, M., Berckmoes, V., De Vos, A., Van De Voorde, S., Verdyck, P., Verpoest, W., & Keymolen, K. (2020) · Reproduction · doi:10.1530/rep-20-0082 · Cited by 34
Metadata
- Authors
- Wilton, L., Thornhill, A., Traeger-Synodinos, J., Sermon, K. D., & Harper, J. C.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-27
- Volume
- 24
- Issue
- 5
- Pages
- 1221-1228
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2119115947
- Cited by
- 300
- References
- 0
- FWCI
- 28.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wilton, L., Thornhill, A., Traeger-Synodinos, J., Sermon, K. D., & Harper, J. C. (2009). The causes of misdiagnosis and adverse outcomes in PGD. Human Reproduction. https://doi.org/10.1093/humrep/den488
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