Cited by 116Reproductive Biology and FertilityOvarian function and disordersReproductive Health and Technologies

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Sub-optimal responders following controlled ovarian stimulation: an overlooked group?

Polyzos, N.P., Sunkara, S.K.·2015·Human Reproduction

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Abstract

Individualization of IVF treatment and tailored stimulation based on predicted ovarian response may maximize treatment success and minimize the risks following IVF. Whilst there has been a consensus in defining poor ovarian response and an attempt to elucidate the threshold for excessive ovarian response based on the number of oocytes retrieved following ovarian stimulation, no systematic effort has been made in order to refine the oocyte yield thresholds for a normal responder. In this opinion article we discuss the evidence behind the oocyte number thresholds for the ovarian response categories and present the rationale and merits in recognizing a new, overlooked, ovarian response group: The sub-optimal ovarian responders.

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Authors: Polyzos, N. P., & Sunkara, S. K.
Affiliations: Vrije Universiteit Brussel (BE)
University of Aberdeen (GB)
Corresponding author: Polyzos, N.P.
ORCID: Polyzos, N.P.
Sunkara, S.K.
Venue: Human Reproduction
Publisher: Oxford University Press (OUP)
Published: 2015-07-21
Volume: 30
Issue: 9
Pages: 2005-2008
ISSN: 0268-1161 (ISSN-L)
1460-2350
DOI: 10.1093/humrep/dev149
OpenAlex: W2101104610
Cited by: 106
References: 26
Citations by year: 2026: 2 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 14 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 3
FWCI: 8.58
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction (publishedVersion)
PubMed (publishedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords: controlled ovarian stimulation, poor ovarian response, oocyte retrieval
MeSH terms: Adult, Cell Count, Female, Humans, Oocytes, Ovulation Induction, Reference Values, Treatment Outcome, Evidence-Based Medicine

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Sub-optimal responders following controlled ovarian stimulation: an overlooked group?

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