The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Sub-optimal responders following controlled ovarian stimulation: an overlooked group?
Abstract
Individualization of IVF treatment and tailored stimulation based on predicted ovarian response may maximize treatment success and minimize the risks following IVF. Whilst there has been a consensus in defining poor ovarian response and an attempt to elucidate the threshold for excessive ovarian response based on the number of oocytes retrieved following ovarian stimulation, no systematic effort has been made in order to refine the oocyte yield thresholds for a normal responder. In this opinion article we discuss the evidence behind the oocyte number thresholds for the ovarian response categories and present the rationale and merits in recognizing a new, overlooked, ovarian response group: The sub-optimal ovarian responders.
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“Ovarian responsiveness is crucial for the success of IVF (Polyzos and Sunkara, 2015) and, according to Sugita et al. (2013), the decrease in ovarian reserve may not be limited to the immediate post-operative period because of removal of ovarian cortex but may be progressive with time based on different pathogenic mechanisms.”
From When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement (2019) · cites this paper as Polyzos and Sunkara, 2015
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Ferraretti, A. P., La Marca, A., Fauser, B. C. J. M., Tarlatzis, B., Nargund, G., Gianaroli, L., & on behalf of the ESHRE working group on Poor Ovarian Response Definition (2011) · Human Reproduction · doi:10.1093/humrep/der092 · Cited by 1,882
Sunkara, S. K., Rittenberg, V., Raine-Fenning, N., Bhattacharya, S., Zamora, J., & Coomarasamy, A. (2011) · Human Reproduction · doi:10.1093/humrep/der106 · Cited by 924
Self-citationBaart, E. B., Martini, E., Eijkemans, M. J., Van Opstal, D., Beckers, N. G. M., Verhoeff, A., Macklon, N. S., & Fauser, B. C. J. M. (2007) · Human Reproduction · doi:10.1093/humrep/del484 · Cited by 609
An OHSS-Free Clinic by segmentation of IVF treatment
Devroey, P., Polyzos, N. P., & Blockeel, C. (2011) · Human Reproduction · doi:10.1093/humrep/der251 · Cited by 514
Self-citationTrounson, A. O., Leeton, J. F., Wood, C., Webb, J., & Wood, J. (1981) · Science · doi:10.1126/science.7221557 · Cited by 379
Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis
van Loendersloot, L. L., van Wely, M., Limpens, J., Bossuyt, P. M. M., Repping, S., & van der Veen, F. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq015 · Cited by 338
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Optimum number of oocytes for a successful first IVF treatment cycle
van der Gaast, M., Eijkemans, M., van der Net, J., de Boer, E., Burger, C., van Leeuwen, F., Fauser, B., & Macklon, N. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60633-5 · Cited by 229
Polyzos, N. P., & Devroey, P. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.048 · Cited by 227
Self-citationVerberg, M. F. G., Eijkemans, M. J. C., Macklon, N. S., Heijnen, E. M. E. W., Baart, E. B., Hohmann, F. P., Fauser, B. C. J. M., & Broekmans, F. J. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn053 · Cited by 221
Research works printed but not linked: 1
- Hamoda, 2010, Outcome of fresh IVF/ICSI cycles in relation to the number of oocytes collected: a review of 4,701 treatment cycles, Hum Reprod, 25, 147
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Items 101–116 of 116
Ulubaşoğlu, H., Bakay, K., Yavuzcan, A., Güven, D., Hatırnaz, Ş., & Dahan, M. H. (2022) · Research Square · doi:10.21203/rs.3.rs-1380129/v1
Miracle Pregnancy: Management of Poor Responder in In-Vitro Fertilization
Sethi, A., Singh, N., Patel, G., & Saini, M. (2022) · Global Journal of Reproductive Medicine · doi:10.19080/gjorm.2022.09.555754
Technical laboratory procedures faced on many oocytes picked up in vitro fertilization cycles
Morishima, C., Donadio, N. F., Gebrim, L. H., & Bonetti, T. C. (2025) · JBRA · doi:10.5935/1518-0557.20250015
Approaches to frozen embryo transfer: a Canadian Fertility and Andrology Society guideline
Saumet, J., Dahdouh, E. M., Sylvestre, C. V., Shapiro, H. M., Min, J. K., Roberts, J., Liu, K. E., Vélez, M. P., MAHUTTE, N. G., Sierra, S., et al. (2025) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2025.105373
Chua, S. J., Mol, B. W., Longobardi, S., Orvieto, R., Venetis, C. A., Lispi, M., Storr, A., & D’Hooghe, T. (2021) · Figshare · doi:10.6084/m9.figshare.14361321
Correa, N., Cerquides, J., Arcos, J. L., Vassena, R., & Popovic, M. (2024) · Figshare · doi:10.6084/m9.figshare.26666557
Wei, J., Luo, Z., Dong, X., Jin, H., Zhu, L., & 艾继辉 (2023) · Figshare · doi:10.6084/m9.figshare.24628036
Correa, N., Cerquides, J., Arcos, J. L., Vassena, R., & Popovic, M. (2024) · Figshare · doi:10.6084/m9.figshare.26666554
Correa, N., Cerquides, J., Arcos, J. L., Vassena, R., & Popovic, M. (2024) · Figshare · doi:10.6084/m9.figshare.26666551
Đánh giá hiệu quả tạo phôi của noãn non trưởng thành bằng Rescue IVM
Thảo, Đ. P., Mạnh, N. V., Thoa, N. N. K., Đạt, Đ. T., An, N. H. M., & Sơn, N. K. (2025) · Tạp chí Nghiên cứu Y học · doi:10.52852/tcncyh.v197i12.4445
Amr, H. M., Gaafar, T., Elwakeel, R. E. M., Sharaf, M. A., & Hanna, M. O. F. (2026) · American Journal of Reproductive Immunology · doi:10.1111/aji.70221
Boonlong, N., Salang, L., Proungvitaya, S., Maraming, P., Daduang, J., Pongsritasana, T., Sukkasame, S., & HAOHAN, S. (2026) · In Vivo · doi:10.21873/invivo.14300
Seah, M. K. Y., Carter, S. W. D., Usuda, H., Rekhawasin, T., Sim, W. E., Sesurajan, B. P., Fee, E. L., Kumagai, Y., Shen, L., Subhasri, T., et al. (2026) · Reproduction · doi:10.1093/reprod/xaag088
Meng, W., Pan, Y., Zhang, M., Song, Z., Xiao, Z., Liang, R., Shi, X., Bao, H., Zhuang, L., & Lü, Q. (2026) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-026-09783-x
Ovarian response to FSH differs by ethnicity: evidence from clinical outcomes and genetic clustering
Neves, A. R., Casarini, L., Carretta, C., Manfredini, R., Martínez, S. G., Vuong, N. L., Blockeel, C., Simoni, M., & Polyzos, N. P. (2026) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2026.106012
Self-citationMedić, N., Roje, D., & Goldštajn, M. Š. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15218497
Metadata
- Authors
- Polyzos, N. P., & Sunkara, S. K.
- Affiliations
- Vrije Universiteit Brussel (BE)
- University of Aberdeen (GB)
- Corresponding author
- Polyzos, N.P.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-07-21
- Volume
- 30
- Issue
- 9
- Pages
- 2005-2008
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2101104610
- Cited by
- 106
- References
- 26
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 14 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 3
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- controlled ovarian stimulation, poor ovarian response, oocyte retrieval
- MeSH terms
- Adult, Cell Count, Female, Humans, Oocytes, Ovulation Induction, Reference Values, Treatment Outcome, Evidence-Based Medicine
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