CoChat
Sign Up
Cited by 266Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and DisordersReproductive Biology and Fertility

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome

Bernard, Valérie, Donadille, Bruno, Zenaty, Delphine, Courtillot, Carine, Salenave, Sylvie, Brac de la Perrière, Aude, Albarel, Frédérique, Fèvre, Anne, Kerlan, Véronique, Brue, Thierry, Delemer, Brigitte, Borson-Chazot, Françoise, Carel, Jean-Claude, Chanson, Philippe, Léger, Juliane, Touraine, Philippe, Christin-Maitre, Sophie·2016·Human Reproduction
DOI 10.1093/humrep/dew012
Open this paper in CoChat — free account

Abstract

STUDY QUESTION: What are the prevalence and the outcomes of spontaneous pregnancies (SP) in a large cohort of French women with Turner syndrome (TS)? SUMMARY ANSWER: Amongst 480 women with TS, 27 women (5.6%) had a total of 52 SP, with 30 full-term deliveries for 18 women. WHAT IS KNOWN ALREADY: Primary ovarian insufficiency is a classic feature of TS. So far, few studies have evaluated the rate of SP in these patients. STUDY DESIGN, SIZE, DURATION: The French Ministry of Health set up a National Reference Centre for Rare Growth Disorders (CRMERC), including TS. We studied a cohort of adult TS patients from seven endocrine units (Saint-Antoine, Pitié-Salpêtrière, Bicêtre, Lyon, Marseille, Brest, Reims Hospitals) belonging to this centre, between January 1999 and January 2014. PARTICIPANTS/MATERIALS, SETTING, METHODS: A total of 480 adult patients with TS were included. The patients' clinical characteristics, karyotypes and reproductive histories had been collected, after informed consent, in a web database called CEMARA. Our reference population was issued from a database belonging to the French Health Ministry, collecting pregnancy outcomes in the French general population. In order to find predictive characteristics of SP, TS with spontaneous pregnancies were compared with non-pregnant TS patients from our cohort. MAIN RESULTS AND THE ROLE OF CHANCE: There were 27 patients (5.6%) who had a total of 52 SP. The two predictive factors which correlated with occurrence of a SP were spontaneous menarche and mosaic karyotype. The median delay to conception was 6 months (range 0-84). Miscarriage occurred in 16 pregnancies, 30.8% versus 15% in the general French population (P < 0.01). The remaining pregnancy outcomes were legal abortion (n = 2), medical interruption (n = 3), intrauterine fetal death (n = 1) and delivery at term (n = 30). Caesarean section rates were higher than in the general population, respectively 46.7% versus 21% (P < 0.001). Pregnancy-induced hypertensive disorders (PHDs) occurred in four cases (13.3%), including two cases of mild pre-eclampsia (6.7%). Neither aortic root dilatation nor aortic dissection were observed. The median birthweight was 3030 g (range 2020-3460). Two cases of TS were identified in the 17 daughters issued from this cohort. LIMITATIONS, REASONS FOR CAUTION: It would have been interesting to evaluate AMH levels and SP occurrence, as a predictive factor. Unfortunately, hormonal measurements were missing for some patients. Prospective studies are necessary to display prognostic values of AMH for SP and thus better target fertility preservation programmes in TS patients. WIDER IMPLICATIONS OF THE FINDINGS: This study suggests that pregnancy outcomes in SPs are more favourable than those after oocyte donation in TS patients. However, the risk of fetal chromosomal abnormalities remains high. Our study will be useful in order to give patients with TS, their families, paediatricians and physicians involved in reproduction, better counselling concerning their fertility. STUDY FUNDING/COMPETING INTERESTS: Funding was provided by the Association pour la recherche Claude Bernard, Paris France All authors claim no competing interests. TRIAL REGISTRATION NUMBER: NA.

Overview

Integrity signals

Registry

Crossref · 10.1093/humrep/dew012

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 38 references

1 of the 38 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. 10.1210/jc.87.8.3618 · DOI
  2. 10.1210/jc.82.6.1810 · DOI
  3. 10.1093/humrep/ · DOI

Cited by

Sorted by citations

See all 266

Related

Metadata

Authors
Bernard, V., Donadille, B., Zenaty, D., Courtillot, C., Salenave, S., Brac de la Perrière, A., Albarel, F., Fèvre, A., Kerlan, V., Brue, T., Delemer, B., Borson-Chazot, F., Carel, J.-C., Chanson, P., Léger, J., Touraine, P., & Christin-Maitre, S.
Affiliations
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Centre National de la Recherche Scientifique (FR)
  • Centre Hospitalier Universitaire de Reims (FR)
  • Inserm (FR)
ORCID
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2016-02-13
Volume
31
Issue
4
Pages
782-788
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/dew012
OpenAlex
W2292201919
Cited by
266
References
38
Citations by year
2026: 15 · 2025: 28 · 2024: 29 · 2023: 26 · 2022: 30 · 2021: 17 · 2020: 34 · 2019: 25 · 2018: 48 · 2017: 11
FWCI
22.60
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Association pour la recherche Claude Bernard
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
Turner syndrome, spontaneous conception, fertility, pregnancy outcomes, primary ovarian insufficiency, miscarriage, cesarean section, preeclampsia, mosaic karyotype, aortic root dilatation, aortic dissection, reproductive history, French women, rare disease registry
MeSH terms
Adolescent, Adult, Aged, Female, Fertility, Follow-Up Studies, France, Humans, Menarche, Middle Aged, Mosaicism, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Registries, Turner Syndrome, Cohort Studies, Primary Ovarian Insufficiency, Reproductive History, Pregnancy Rate, Young Adult, Time-to-Pregnancy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review