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Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus
Abstract
Study question What were the risks with regard to the pregnancy outcomes of patients who conceived by frozen-thawed embryo transfer (FET) during a hormone replacement cycle (HRC-FET)? Summary answer The patients who conceived by HRC-FET had increased risks of hypertensive disorders of pregnancy (HDP) and placenta accreta and a reduced risk of gestational diabetes mellitus (GDM) in comparison to those who conceived by FET during a natural ovulatory cycle (NC-FET). What is known already Previous studies have shown that pregnancy and live-birth rates after HRC-FET and NC-FET are comparable. Little has been clarified regarding the association between endometrium preparation and other pregnancy outcomes. Study design, size, duration A retrospective cohort study of patients who conceived after HRC-FET and those who conceived after NC-FET was performed based on the Japanese assisted reproductive technology registry in 2014. Participants/materials, setting, methods The pregnancy outcomes were compared between NC-FET (n = 29 760) and HRC-FET (n = 75 474) cycles. Multiple logistic regression analyses were performed to investigate the potential confounding factors. Main results and the role of chance The pregnancy rate (32.1% vs 36.1%) and the live birth rate among pregnancies (67.1% vs 71.9%) in HRC-FET cycles were significantly lower than those in NC-FET cycles. A multiple logistic regression analysis showed that pregnancies after HRC-FET had increased odds of HDPs [adjusted odds rati…
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Endometrial preparation with artificial cycle FET has been shown to be associated with higher rates of hypertensive disorders in pregnancy, postpartum haemorrhage, and preterm birth compared with normal cycle FET.
“Endometrial preparation with artificial cycle FET has been shown to be associated with higher rates of hypertensive disorders in pregnancy, postpartum haemorrhage, and preterm birth compared with normal cycle FET. 27,28”
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International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010) · Diabetes Care · doi:10.2337/dc09-1848 · Cited by 5,390
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Ishihara, O., Jwa, S. C., Kuwahara, A., Katagiri, Y., Kuwabara, Y., Hamatani, T., Harada, M., & Ichikawa, T. (2020) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12307 · Cited by 63
Self-citationHo, V. N. A., Pham, T. D., Nguyen, N. T., Wang, R., Norman, R. J., Mol, B. W., Ho, T. M., & Vuong, L. N. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00756-6 · Cited by 55
Metadata
- Authors
- Saito, K., Kuwahara, A., Ishikawa, T., Morisaki, N., Miyado, M., Miyado, K., Fukami, M., Miyasaka, N., Ishihara, O., Irahara, M., & Saito, H.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Tokushima University (JP)
- National Center For Child Health and Development (JP)
- National Research Institute for Child Health and Development (JP)
- Saitama Medical University (JP)
- Corresponding author
- Saito, Kazuki
- ORCID
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-07-12
- Volume
- 34
- Issue
- 8
- Pages
- 1567-1575
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2959031195
- Cited by
- 233
- References
- 1
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 23 · 2023: 38 · 2022: 53 · 2021: 43 · 2020: 24 · 2019: 4
- FWCI
- 32.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (19H01067, 17H06428, 19K09682)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- frozen embryo transfer, endometrial preparation, hormone replacement cycle, natural cycle, hypertensive disorders of pregnancy, placenta accreta, gestational diabetes mellitus, pregnancy outcomes, live birth rate, pregnancy rate, assisted reproduction, endometrial receptivity, endometrial receptivity array, endometrial receptivity gene expression, endometrial receptivity score, endometrial receptivity index
- MeSH terms
- Adult, Birth Rate, Embryo Transfer, Female, Humans, Placenta Accreta, Pregnancy, Pregnancy Outcome, Retrospective Studies, Risk, Cryopreservation, Incidence, Diabetes, Gestational, Pregnancy Rate, Hypertension, Pregnancy-Induced, Live Birth
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