Pregnancy complications in women with polycystic ovary syndrome
Open accessAbstract
Background The great majority of studies performed so far concerning women diagnosed with polycystic ovary syndrome (PCOS) have focused on diagnosis, menstrual cycle abnormalities, hirsutism and infertility. Although progress has been made in developing methods for achieving a pregnancy and reducing multiple gestations in women with PCOS, little attention has been paid to pregnancy complications and subsequent child outcomes. This review aims to summarize current knowledge regarding the clinical and pathophysiological features of pregnancy and children in women with PCOS. Methods A literature search up to April 2015 was performed in PubMed, Medline, the Cochrane Library and Web of Science without language restriction. All articles were initially screened for title and abstract and full texts of eligible articles were subsequently selected. Systematic reviews with meta-analysis were initially included for each specific subject. Recent randomised controlled trials (RCTs), which were not included in the systematic reviews, were also included. In addition to evidence from meta-analyses or RCTs, we used non-randomized prospective, uncontrolled prospective, retrospective and experimental studies. When specific data for patients with PCOS were lacking, results from general population studies were reported. Results Women with PCOS exhibit a clinically significant increased risk of pregnancy complications compared with controls. Data which were not adjusted for BMI or other confounder…
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Those with PCOS have an increased risk of pregnancy complications such as gestational diabetes and pre-eclampsia, and post-partum risk for diabetes and cardiovascular disease.
“Those with PCOS have an increased risk of pregnancy complications such as gestational diabetes and pre-eclampsia, and post-partum risk for diabetes and cardiovascular disease.”
From Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care (2023) · cites this paper as [55]
PCOS is associated with a higher incidence of fertility assistance and complications of pregnancy, including gestational hypertension and diabetes.
“PCOS is associated with a higher incidence of fertility assistance and complications of pregnancy, including gestational hypertension and diabetes.12,17,18,21, 22, 23, 24”
From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [22]
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“Therefore, early intervention to target cardiometabolic risk factors following a diagnosis of PCOS is strongly recommended [3, 55, 56].”
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Self-citation
- Authors
- Palomba, S., de Wilde, M. A., Falbo, A., Koster, M. P. H., La Sala, G. B., & Fauser, B. C. J. M.
- Affiliations
- Santa Maria Nuova Hospital (IT)
- University Medical Center Utrecht (NL)
- Corresponding author
- Palomba, Stefano
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-06-27
- Volume
- 21
- Issue
- 5
- Pages
- 575-592
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2133883611
- Cited by
- 691
- References
- 27
- Citations by year
- 2026: 59 · 2025: 84 · 2024: 92 · 2023: 100 · 2022: 109 · 2021: 65 · 2020: 51 · 2019: 47 · 2018: 32 · 2017: 25 · 2016: 14 · 2015: 11 · 2012: 1
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- other-oa
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- polycystic ovary syndrome, pregnancy complications, gestational hypertension, preeclampsia, gestational diabetes mellitus, preterm birth, hyperandrogenism, insulin resistance, obesity, offspring metabolic outcomes, long-term maternal health
- MeSH terms
- Abortion, Spontaneous, Female, Hirsutism, Humans, Infertility, Female, Menstruation Disturbances, Polycystic Ovary Syndrome, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Prospective Studies, Retrospective Studies, Randomized Controlled Trials as Topic, Diabetes, Gestational, Hyperandrogenism, Premature Birth
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