The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Smoking and reproduction: gene damage to human gametes and embryos
Abstract
Assisted conception is a useful methodology for detecting disturbances in clinical outcome, meiotic maturation, and genetic integrity of human gametes. Germinal cells are vulnerable to genetic damage from smoking, but can repair damage during meiosis. In ejaculated spermatozoa, repair capacity declines drastically. Smoking alters the meiotic spindle of oocytes and spermatozoa, leading to chromosome errors which affect reproductive outcomes. Smoking is associated with reduced numbers of retrieved oocytes, leading to early age of menopause. Oocyte elimination occurs preferentially during meiosis I, a period sensitive to genetic damage. Smoking inhibits embryo fragmentation; inhibition may confer survival advantage to embryos genetically altered. Smoking is associated with low sperm quality, but clinical effects are not recognized. Cadmium (a heavy metal), nicotine (a toxic alkaloid), and its metabolite cotinine, are detectable in gonadal tissues and fluids in association with smoking. Cotinine incorporates into ovarian granulosa-lutein cells, compromising the developmental potential of follicles. Benzo[a]pyrene is a carcinogenic polycyclic aromatic hydrocarbon resulting from cigarette combustion. Its reactive metabolite binds covalently to DNA, forming adducts. Smoking-related adducts were detectable in ovarian granulosa-lutein cells, oocytes, spermatozoa and preimplantation embryos. Transmission of altered DNA from smoking by spermatozoa was demonstrated in preimplantation embryos and in association with increased risk of childhood cancer.
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Cites
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Cited by
Sharma, R., Harlev, A., Agarwal, A., & Esteves, S. C. (2016) · European Urology · doi:10.1016/j.eururo.2016.04.010 · Cited by 532
Determinants of Mutation Rate Variation in the Human Germline
Ségurel, L., Wyman, M. J., & Przeworski, M. (2014) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-031714-125740 · Cited by 289
Is smoking a risk factor for decreased semen quality? A cross-sectional analysis
Ramlau-Hansen, C. H., Thulstrup, A. M., Aggerholm, A. S., Jensen, M. S., Toft, G., & Bonde, J. P. (2007) · Human Reproduction · doi:10.1093/humrep/del364 · Cited by 289
Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis
Bundhun, P. K., Janoo, G., Bhurtu, A., Teeluck, A. R., Soogund, M. Z. S., Pursun, M., & Huang, F. (2019) · BMC Public Health · doi:10.1186/s12889-018-6319-3 · Cited by 154
Is prenatal exposure to tobacco smoking a cause of poor semen quality? A follow-up study
Ramlau-Hansen, C. H., Thulstrup, A. M., Storgaard, L., Toft, G., Olsen, J., & Bonde, J. P. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm032 · Cited by 139
Metadata
- Authors
- Zenzes, M. T.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 6
- Issue
- 2
- Pages
- 122-131
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2128843448
- Cited by
- 396
- References
- 91
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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