The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Conception to ongoing pregnancy: the 'black box' of early pregnancy loss
Open accessAbstract
Even when conditions are optimal, the maximum chance of a clinically recognized pregnancy occurring in a given menstrual cycle is 30-40%. Increasing evidence points to preclinical pregnancy loss rather than failure of conception as the principal cause for the relatively low fecundity observed in humans. While sensitive assays for hCG have provided a glimpse of the events occurring between implantation and the missed menstrual period, new cytogenetic techniques have further opened this 'black box', providing novel insights into the causes of early pregnancy wastage. In this article, the evidence and causes of preclinical or 'occult' pregnancy are reviewed, and the implications for the infertile patient are addressed.
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Citations
Cites
Incidence of early loss of pregnancy
Wilcox, A. J., Weinberg, C. R., O'Connor, J. F., Baird, D. D., Schlatterer, J. P., Canfield, R. E., Armstrong, E. G., & Nisula, B. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190401 · Cited by 2,354
Time of Implantation of the Conceptus and Loss of Pregnancy
Wilcox, A. J., Baird, D. D., & Weinberg, C. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402304 · Cited by 1,081
Early embryonic mortality in women
Edmonds, D. K., Lindsay, K. S., Miller, J. F., Williamson, E., & Wood, P. J. (1982) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46579-9 · Cited by 512
Slama, R. (2002) · Human Reproduction · doi:10.1093/humrep/17.2.503 · Cited by 308
Cited by
Ovarian aging: mechanisms and clinical consequences
Broekmans, F. J., Soules, M. R., & Fauser, B. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0006 · Cited by 1,248
Chromosome instability is common in human cleavage-stage embryos
Vanneste, E., Voet, T., Le Caignec, C., Ampe, M., Konings, P., Melotte, C., Debrock, S., Amyere, M., Vikkula, M., Schuit, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.1924 · Cited by 880
DNA methylation signatures link prenatal famine exposure to growth and metabolism
Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms6592 · Cited by 630
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 587
Single Cell Genomics: Advances and Future Perspectives
Macaulay, I. C., & Voet, T. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004126 · Cited by 384
Metadata
- Authors
- Macklon, N. S.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-07-01
- Volume
- 8
- Issue
- 4
- Pages
- 333-343
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2111676688
- Cited by
- 783
- References
- 4
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
