The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
Inhibins, activins and follistatin in reproduction
Abstract
The regulation of reproductive processes involves a complex network of communication systems between the brain, endocrine organs, the gonads and other reproductive tissues. Classically, our understanding has focused on the role of endocrine hormones, but more recently interest has also dwelt on the paracrine and autocrine regulation of these cell systems. In this review, the structure and physiology of the inhibins, activins and follistatin are discussed in terms of the evidence supporting their role as endocrine hormones, and how they might function as paracrine factors within the pituitary, gonad and associated tissues. With the advent of more specific techniques and assays for their measurement, the potential of inhibins, activins and follistatin as clinical markers of reproductive function and in the screening of various pathologies is also evaluated.
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“FST acts as a multi-faceted hepatokine that is involved in reproduction [181], muscle growth [182], cancer development [183], and metabolism [184].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [181]
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Cites
Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920
Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid
Vale, W., Rivier, J., Vaughan, J. M., McClintock, R. A., CORRIGAN, A. Z., WOO, W., Karr, D., & Spiess, J. (1986) · Nature · doi:10.1038/321776a0 · Cited by 1,155
Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin
LING, N. C., Ying, S., Ueno, N., Shimasaki, S., Esch, F. S., Hotta, M., & Guillemin, R. (1986) · Nature · doi:10.1038/321779a0 · Cited by 1,082
Measurement of dimeric inhibin B throughout the human menstrual cycle
Groome, N. P., Illingworth, P. J., O'Brien, M., Pai, R., Rodger, F. E., Mather, J. P., & McNeilly, A. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636341 · Cited by 949
α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice
Matzuk, M. M., Finegold, M. J., Su, J.-G. J., Hsueh, A. J. W., & Bradley, A. (1992) · Nature · doi:10.1038/360313a0 · Cited by 893
Activin-Binding Protein from Rat Ovary Is Follistatin
Nakamura, T., Takio, K., Eto, Y., Shibai, H., Titani, K., & Sugino, H. (1990) · Science · doi:10.1126/science.2106159 · Cited by 883
Pattern formation by local self-activation and lateral inhibition
Meinhardt, H., & Gierer, A. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 629
Different phenotypes for mice deficient in either activins or activin receptor type II
Matzuk, M. M., Kumar, T. R., & Bradley, A. (1995) · Nature · doi:10.1038/374356a0 · Cited by 589
Multiple defects and perinatal death in mice deficient in follistatin
Matzuk, M. M., Lu, N., Vogel, H. S., Sellheyer, K., Roop, D. R., & Bradley, A. (1995) · Nature · doi:10.1038/374360a0 · Cited by 584
Functional analysis of activins during mammalian development
Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578
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Regulation of Muscle Mass by Follistatin and Activins
Lee, S.-J., Lee, Y.-S., Zimmers, T. A., Soleimani, A., Matzuk, M. M., Tsuchida, K., Cohn, R. D., & Barton, E. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0127 · Cited by 273
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252
Allaway, H. C. M., Southmayd, E. A., & De Souza, M. J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0053 · Cited by 89
Role of exercise-induced hepatokines in metabolic disorders
Ennequin, G., Sirvent, P., & Whitham, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2018 · Cited by 54
Dalcq, J., Pasque, V., Ghaye, A., Larbuisson, A., Motte, P., Martial, J. A., & Muller, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050140 · Cited by 52
Metadata
- Authors
- de Kretser, D. M.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 8
- Issue
- 6
- Pages
- 529-541
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2166390226
- Cited by
- 211
- References
- 223
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 3 · 2013: 12 · 2012: 13
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- inhibin, activin, follistatin, reproductive control, paracrine signaling, autocrine regulation, endocrine hormones, pituitary gland, gonads
- MeSH terms
- Animals, Female, Follicle Stimulating Hormone, Humans, Inhibins, Male, Ovary, Pregnancy, Reproduction, Testis, Activins, Follistatin
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