Role of exercise-induced hepatokines in metabolic disorders

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works

Lack of Exercise Is a Major Cause of Chronic Diseases

Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works

Nonalcoholic Fatty Liver Disease

Rinella, M. E. (2015) · JAMA · doi:10.1001/jama.2015.5370 · Cited by 2,289 · see citing works

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

Chen, L., Magliano, D. J., & Zimmet, P. Z. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.183 · Cited by 2,227 · see citing works

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

Adams, L. A., Anstee, Q. M., Tilg, H., & Targher, G. (2017) · Gut · doi:10.1136/gutjnl-2017-313884 · Cited by 1,210 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095 · see citing works

Identification and characterization of metabolically benign obesity in humans

Stefan, N. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1609 · Cited by 1,049 · see citing works

Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

Koliaki, C., Szendroedi, J., Kaul, K., Jelenik, T., Nowotny, P., Jankowiak, F., Herder, C., Carstensen, M., Krausch, M., Knoefel, W. T., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.004 · Cited by 1,032 · see citing works

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

Stefan, N., Häring, H., & Cusi, K. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30154-2 · Cited by 848 · see citing works

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00067-1 · Cited by 847 · see citing works

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748 · see citing works

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works

Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running

Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.949bp.x · Cited by 673 · see citing works

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631 · see citing works

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes · doi:10.2337/db14-0595 · Cited by 590 · see citing works

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works

HSP72 protects against obesity-induced insulin resistance

Chung, J., Nguyen, A.-K., Henstridge, D. C., Holmes, A. G., Chan, M. H. S., Mesa, J. L., Lancaster, G. I., Southgate, R. J., Bruce, C. R., Duffy, S. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705799105 · Cited by 553 · see citing works

Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants

Petryszak, R., Keays, M., Tang, A., Fonseca, N. A., Barrera, E., Burdett, T., Füllgrabe, A., Fuentes, A. M.-P., Jupp, S., Koskinen, S., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1045 · Cited by 530 · see citing works

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review

Thoma, C., Day, C. P., & Trenell, M. I. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.06.010 · Cited by 523 · see citing works

Muscle as a secretory organ

Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120033 · Cited by 516 · see citing works

The role of hepatokines in metabolism

Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works

Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497 · see citing works

α2-Heremans-Schmid Glycoprotein/ Fetuin-A Is Associated With Insulin Resistance and Fat Accumulation in the Liver in Humans

Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Kröber, S. M., Machicao, F. E., Fritsche, A., & Häring, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1938 · Cited by 475 · see citing works

Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice

Kawanishi, N., Yano, H., Yokogawa, Y., & Suzuki, K. (2026) · PubMed · doi:10.22029/eir.2010.1655 · Cited by 456 · see citing works

Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction

Febbraio, M. A., Hiscock, N., Sacchetti, M., Fischer, C. P., & Pedersen, B. K. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1643 · Cited by 455 · see citing works

Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

Song, M. J., Kim, K. H., Yoon, J. M., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.170 · Cited by 454 · see citing works

Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects

Bruun, J. M., Helge, J. W., Richelsen, B., & Stallknecht, B. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00506.2005 · Cited by 431 · see citing works

Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism

Köster, A., Chao, Y. B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P. A., Hale, J. E., Li, D., Qiu, Y., Fraser, C. C., Yang, D. D., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0476 · Cited by 427 · see citing works

FGF21 is an Akt‐regulated myokine

Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415 · see citing works

Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

Li, H., Fang, Q., Gao, F., Fan, J., Zhou, J., Wang, X., Zhang, H., Pan, X., Bao, Y., Xiang, K., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.018 · Cited by 400 · see citing works

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

Izumiya, Y., Hopkins, T., Morris, C., Sato, K., Zeng, L., Viereck, J., Hamilton, J. A., Ouchi, N., LeBrasseur, N. K., & Walsh, K. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.003 · Cited by 395 · see citing works

Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

Chavez, A. O., Molina-Carrion, M., Abdul-Ghani, M. A., Folli, F., DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-0684 · Cited by 390 · see citing works

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., & Maratos-Flier, E. (2009) · Endocrinology · doi:10.1210/en.2009-0532 · Cited by 362 · see citing works

A systematic review and meta‐analysis of interval training versus moderate‐intensity continuous training on body adiposity

Keating, S. E., Johnson, N. A., Mielke, G. I., & Coombes, J. S. (2017) · Obesity Reviews · doi:10.1111/obr.12536 · Cited by 344 · see citing works

Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene

Mathews, S. T., Singh, G. P., Ranalletta, M., Cintrón, V. J., Qiang, X., Goustin, A. S., Jen, K. C., Charron, M. J., Jahnen‐Dechent, W., & Grunberger, G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2450 · Cited by 343 · see citing works

Novel insights in SHBG regulation and clinical implications

Simó, R., Sáez-López, C., Barbosa-Desongles, A., Hernández, C., & Selva, D. M. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.05.001 · Cited by 335 · see citing works

Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification, and anti-mitogenic activity

Auberger, P., Falquerho, L., Contreres, J. O., Pagès, G., Cam, G. L., Rossi, B., & Cam, A. L. (1989) · Cell · doi:10.1016/0092-8674(89)90098-6 · Cited by 321 · see citing works

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Xu, A., Lam, M. C., Chan, K. W., Wang, Y., Zhang, J., Hoo, R. L. C., Xu, J. Y., Chen, B., Chow, W.-S., Tso, A. W. K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408452102 · Cited by 315 · see citing works

Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis

Guo, J., & Friedman, S. L. (2010) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-3-21 · Cited by 311 · see citing works

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

Berglund, E. D., Li, C. Y., Bina, H. A., Lynes, S. E., Michael, M. D., Shanafelt, A. B., Kharitonenkov, A., & Wasserman, D. H. (2009) · Endocrinology · doi:10.1210/en.2009-0221 · Cited by 297 · see citing works

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

Ghorpade, D. S., Özcan, L., Zheng, Z., Nicoloro, S. M. C., Shen, Y., Chen, E., Blüher, M., Czech, M., & Tabas, I. A. (2018) · Nature · doi:10.1038/nature26138 · Cited by 295 · see citing works

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans

Kim, K. H., Kim, S. H., Min, Y.-K., Yang, H.-M., Lee, J.-B., & Lee, M.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063517 · Cited by 290 · see citing works

RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance

Moraes‐Vieira, P. M., Yore, M. M., Dwyer, P., Syed, I., Aryal, P., & Kahn, B. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.018 · Cited by 287 · see citing works

The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications

Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.153 · Cited by 279 · see citing works

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works

Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism

Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.023 · Cited by 255 · see citing works

Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

Gilson, H., Schakman, O., Kalista, S., Lause, P., Tsuchida, K., & Thissen, J.-P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00193.2009 · Cited by 248 · see citing works

Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Hayashino, Y., Jackson, J. L., Hirata, T., Fukumori, N., Nakamura, F., Fukuhara, S., Tsujii, S., & Ishii, H. (2014) · Metabolism · doi:10.1016/j.metabol.2013.08.018 · Cited by 244 · see citing works

Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level

Srinivas, P. R., Wagner, A. S., Reddy, L. V. K., Deutsch, D. D., Leon, M. A., Goustin, A. S., & Grunberger, G. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.11.7906861 · Cited by 243 · see citing works

Primary structure of the human follistatin precursor and its genomic organization

Shimasaki, S., Koga, M., Esch, F., Cooksey, K., Mercado, M., Koba, A., Ueno, N., Ying, S. Y., Ling, N., & Guillemin, R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4218 · Cited by 232 · see citing works

Effect of endurance training on skeletal muscle myokine expression in obese men: Identification of apelin as a novel myokine

Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C., Daviaud, D., Mir, L., Marques, M.-A., Thalamas, C., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.158 · Cited by 227 · see citing works

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity

Mashili, F. L., Austin, R. L., Deshmukh, A. S., Fritz, T., Caidahl, K., Bergdahl, K., Zierath, J. R., Chibalin, A., Moller, D. E., Kharitonenkov, A., et al. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1177 · Cited by 222 · see citing works

Myokines in insulin resistance and type 2 diabetes

Eckardt, K., Görgens, S. W., Raschke, S., & Eckel, J. (2014) · Diabetologia · doi:10.1007/s00125-014-3224-x · Cited by 221 · see citing works

FGF21 and the late adaptive response to starvation in humans

Fazeli, P. K., Lun, M., Kim, S. M., Bredella, M. A., Wright, S., Zhang, Y., Lee, H., Catana, C., Klibanski, A., Patwari, P., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83349 · Cited by 214 · see citing works

Inhibins, activins and follistatin in reproduction

de Kretser, D. M. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.6.529 · Cited by 211 · see citing works

Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

Park, S. E., Park, C., & Sweeney, G. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1023429 · Cited by 206 · see citing works

Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids

Kersten, S., Lichtenstein, L., Steenbergen, E., Mudde, K., Hendriks, H., Hesselink, M. K. C., Schrauwen, P., & Müller, M. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.182147 · Cited by 206 · see citing works

Exercise induces a marked increase in plasma follistatin: Evidence that follistatin is a contraction-induced hepatokine

Hansen, J., Brandt, C., Nielsen, A. R., Hojman, P., Whitham, M., Febbraio, M. A., Pedersen, B. K., & Plomgaard, P. (2011) · Endocrinology · doi:10.1210/en.2010-0868 · Cited by 200 · see citing works

Inventing new medicines: The FGF21 story

Kharitonenkov, A., & Adams, A. C. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.003 · Cited by 198 · see citing works

Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake

Lichtenstein, L., Berbée, J. F. P., van Dijk, S. J., van Dijk, K. W., Bensadoun, A., Kema, I. P., Voshol, P. J., Müller, M. M., Rensen, P. C. N., & Kersten, S. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151894 · Cited by 196 · see citing works

Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease

Rodino‐Klapac, L. R., Haidet, A. M., Kota, J., Handy, C., Kaspar, B. K., & Mendell, J. R. (2009) · Muscle & Nerve · doi:10.1002/mus.21244 · Cited by 194 · see citing works

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans

Febbraio, M. A., Ott, P., Nielsen, H. B., Steensberg, A., Keller, C., Krustrup, P., Secher, N. H., & Pedersen, B. K. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.025148 · Cited by 187 · see citing works

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans

Staiger, H., Haas, C., Machann, J., Werner, R., Weisser, M., Schick, F., Machicao, F., Stefan, N., Fritsche, A., & Häring, H.-U. (2009) · Diabetes · doi:10.2337/db07-1438 · Cited by 183 · see citing works

α2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor

Mathews, S. T. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00237-9 · Cited by 179 · see citing works

Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

Yu, H., Xia, F., Lam, K. S., Wang, Y., Bao, Y., Zhang, J., Gu, Y., Zhou, P., Lu, J., Jia, W., et al. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.155184 · Cited by 170 · see citing works

NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

Dasgupta, S., Bhattacharya, S., Biswas, A., Majumdar, S. S., Mukhopadhyay, S., Ray, S., & Bhattacharya, S. (2010) · Biochemical Journal · doi:10.1042/bj20100330 · Cited by 168 · see citing works

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

Fisher, F. M., Kim, M., Doridot, L., Cunniff, J. C., Parker, T. S., Levine, D. M., Hellerstein, M. K., Hudgins, L. C., Maratos-Flier, E., & Herman, M. A. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2016.11.008 · Cited by 166 · see citing works

Fetuin-A: A novel link between obesity and related complications

Trepanowski, J. F., Mey, J., & Varady, K. A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.203 · Cited by 161 · see citing works

Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans

Stefan, N., & Häring, H.-U. (2013) · Nature Medicine · doi:10.1038/nm.3116 · Cited by 160 · see citing works

Toll-like receptor 4 modulates skeletal muscle substrate metabolism

Frisard, M. I., McMillan, R. P., Marchand, J., Wahlberg, K. A., Wu, Y., Voelker, K. A., Heilbronn, L. K., Haynie, K. R., Muoio, B. M., Li, L., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00307.2009 · Cited by 157 · see citing works

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

Misu, H., Takayama, H., Saito, Y., Mita, Y., Kikuchi, A., Ishii, K.-A., Chikamoto, K., Kanamori, T., Tajima, N., Lan, F., et al. (2017) · Nature Medicine · doi:10.1038/nm.4295 · Cited by 156 · see citing works

Effectiveness and Safety of High-Intensity Interval Training in Patients With Type 2 Diabetes

François, M. E., & Little, J. P. (2015) · Diabetes Spectrum · doi:10.2337/diaspect.28.1.39 · Cited by 153 · see citing works

Metabolic crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion

Gerst, F., Wagner, R., Kaiser, G., Panse, M., Heni, M., Machann, J., Bongers, M. N., Sartorius, T., Sipos, B., Fend, F., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4385-1 · Cited by 151 · see citing works

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers-van Gogh, I., Schaart, G., Jeppesen, J., Kneppers, A., Mensink, M., Voshol, P. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400889111 · Cited by 150 · see citing works

Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women

Yang, S. J., Hong, H. C., Choi, H. Y., Yoo, H. J., Cho, G. J., Hwang, T. G., Baik, S. H., Choi, D. S., Kim, S. M., & Choi, K. M. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04078.x · Cited by 148 · see citing works

The impact of liver fat vs visceral fat in determining categories of prediabetes

Kantartzis, K., Machann, J., Schick, F., Fritsche, A., Häring, H., & Stefan, N. (2010) · Diabetologia · doi:10.1007/s00125-010-1663-6 · Cited by 146 · see citing works

Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice

Kawanishi, N., Yano, H., Mizokami, T., Takahashi, M., Oyanagi, E., & Suzuki, K. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.04.006 · Cited by 136 · see citing works

Exercise and the Regulation of Endocrine Hormones

Hackney, A. C., & Lane, A. R. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.001 · Cited by 136 · see citing works

Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation

Tanimura, Y., Aoi, W., Takanami, Y., Kawai, Y., Mizushima, K., Naito, Y., & Yoshikawa, T. (2016) · Physiological Reports · doi:10.14814/phy2.12828 · Cited by 131 · see citing works

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

Aryal, B. K., Singh, A. K., Zhang, X., Varela, L., Rotllán, N., Goedeke, L., Chaube, B., Camporez, J. P., Vatner, D. F., Horváth, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 131 · see citing works

Fetuin-null mice are protected against obesity and insulin resistance associated with aging

Mathews, S. T., Rakhade, S. N., Zhou, X., Parker, G. C., Coscina, D. V., & Grunberger, G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.071 · Cited by 129 · see citing works

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid

Tan, B. K., Hallschmid, M., Adya, R., Kern, W., Lehnert, H., & Randeva, H. S. (2011) · Diabetes · doi:10.2337/db11-0672 · Cited by 129 · see citing works

Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women

Kong, Z., Sun, S., Liu, M., & Shi, Q. (2016) · Journal of Diabetes Research · doi:10.1155/2016/4073618 · Cited by 126 · see citing works

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

Lundsgaard, A.-M., Fritzen, A. M., Sjøberg, K. A., Myrmel, L. S., Madsen, L., Wojtaszewski, J. F. P., Richter, E. A., & Kiens, B. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2016.11.001 · Cited by 126 · see citing works

Circulating follistatin is liver-derived and regulated by the glucagon-to-insulin ratio

Hansen, J. S., Rutti, S., Arous, C., Clemmesen, J. O., Secher, N. H., Drescher, A., Gonelle-Gispert, C., Halban, P. A., Pedersen, B. K., Weigert, C., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3668 · Cited by 125 · see citing works

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

Hansen, J. S., Clemmesen, J. O., Secher, N. H., Hoene, M., Drescher, A., Weigert, C., Pedersen, B. K., & Plomgaard, P. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.06.001 · Cited by 123 · see citing works

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

Zarei, M., Barroso, E., Palomer, X., Dai, J., Rada, P., Quesada‐López, T., Escolá‐Gil, J. C., Cedó, L., Zali, M. R., Molaei, M., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.008 · Cited by 117 · see citing works

Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes

Gray, N. E., Lam, L. N., Yang, K., Zhou, A. Y., Koliwad, S., & Wang, J.-C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294124 · Cited by 116 · see citing works

Pronounced Effects of Acute Endurance Exercise on Gene Expression in Resting and Exercising Human Skeletal Muscle

Catoire, M., Mensink, M., Boekschoten, M. V., Hangelbroek, R., Müller, M., Schrauwen, P., & Kersten, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051066 · Cited by 116 · see citing works

The Inflamed Liver and Atherosclerosis: A Link Between Histologic Severity of Nonalcoholic Fatty Liver Disease and Increased Cardiovascular Risk

Alkhouri, N., Tamimi, T., Yerian, L. M., López, R., Zein, N. N., & Feldstein, A. E. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-1075-y · Cited by 113 · see citing works

Increased selenoprotein P levels in subjects with visceral obesity and nonalcoholic Fatty liver disease

Choi, H. Y., Hwang, S. Y., Lee, C. H., Hong, H. C., Yang, S. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.63 · Cited by 111 · see citing works

Follistatin Promotes Adipocyte Differentiation, Browning, and Energy Metabolism

Braga, M., Reddy, S. T., Vergnes, L., Pervin, S., Grijalva, V., Stout, D., David, J., Li, X., Tomasian, V., Reid, C. B., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m039719 · Cited by 111 · cited 1× · see citing works

Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans

Morville, T. H., Sahl, R. E., Trammell, S. A. J., Svenningsen, J. S., Gillum, M. P., Helge, J. W., & Clemmensen, C. (2018) · JCI Insight · doi:10.1172/jci.insight.122737 · Cited by 111 · see citing works

Effects of elastic band resistance training and nutritional supplementation on muscle quality and circulating muscle growth and degradation factors of institutionalized elderly women: the Vienna Active Ageing Study (VAAS)

Hofmann, M., Schober-Halper, B., Oesen, S., Franzke, B., Tschan, H., Bachl, N., Strasser, E.-M., Quittan, M., Wagner, K., & Wessner, B. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3344-8 · Cited by 106 · see citing works

Exercise-induced secretion of FGF21 and follistatin are blocked by pancreatic clamp and impaired in type 2 diabetes

Hansen, J. S., Pedersen, B. K., Xu, G., Lehmann, R., Weigert, C., & Plomgaard, P. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1681 · Cited by 106 · see citing works

Inactivating hepatic follistatin alleviates hyperglycemia

Tao, R., Wang, C., Stöhr, O., Qiu, W., Hu, Y., Miao, J., Dong, X. C., Leng, S., Stefater, M., Stylopoulos, N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0048-0 · Cited by 104 · see citing works

Endurance Exercise Reduces Hepatic Fat Content and Serum Fibroblast Growth Factor 21 Levels in Elderly Men

Taniguchi, H., Tanisawa, K., Sun, X., Kubo, T., & Higuchi, M. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3308 · Cited by 102 · see citing works

Retinoic Acid Receptor β Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in Mice

Li, Y., Wong, K., Walsh, K., Gao, B., & Zang, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.429852 · Cited by 101 · see citing works

An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function.

Lee, J. H., Kang, Y. E., Chang, J. Y., Park, K. C., Kim, H.-W., Kim, J. T., Kim, H. J., Yi, H., Shong, M., Chung, H. K., et al. (2016) · PubMed Central · Cited by 101 · see citing works

Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi

Xiong, X., Wang, Q., Wang, S., Zhang, J., Liu, T., Guo, L., Yu, Y., & Lin, J. D. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2018.12.004 · Cited by 100 · see citing works

A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes

Wu, H.-T., Ou, H.-Y., Hung, H.-C., Su, Y.-C., Lu, F.-H., Wu, J.-S., Yang, Y.-C., Wu, C.-L., & Chang, C.-J. (2016) · Diabetologia · doi:10.1007/s00125-016-3991-7 · Cited by 96 · see citing works

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K., & Kersten, S. (2018) · Diabetologia · doi:10.1007/s00125-018-4583-5 · Cited by 96 · see citing works

Glucose ingestion attenuates the exercise-induced increase in circulating heat shock protein 72 and heat shock protein 60 in humans

Febbraio, M. A., Mesa, J. L. M., Chung, J. Z. Y., Steensberg, A., Keller, C., Nielsen, H. B., Krustrup, P., Ott, P., Secher, N. H., & Pedersen, B. K. (2004) · Cell Stress and Chaperones · doi:10.1379/csc-24r1.1 · Cited by 95 · see citing works

Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross-Sectional Study

Yan, H., Xia, M., Chang, X., Xu, Q., Bian, H., Zeng, M., Rao, S., Yao, X., Tu, Y., Jia, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024895 · Cited by 95 · see citing works

Deoxyribonucleotides as genetic and metabolic regulators

Mathews, C. K. (2014) · The FASEB Journal · doi:10.1096/fj.14-251249 · Cited by 95 · see citing works

Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise

Hoene, M., Lehmann, R., Hennige, A. M., Pohl, A. K., Häring, H. U., Schleicher, E. D., & Weigert, C. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160275 · Cited by 92 · see citing works

The role of hepassocin in the development of non-alcoholic fatty liver disease

Wu, H.-T., Lu, F.-H., Ou, H.-Y., Su, Y.-C., Hung, H.-C., Wu, J.-S., Yang, Y.-C., Wu, C.-L., & Chang, C.-J. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.06.004 · Cited by 92 · see citing works

Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes: a meta-analysis with bias analysis

Morrison, A. E., Zaccardi, F., Khunti, K., & Davies, M. J. (2019) · Liver International · doi:10.1111/liv.13994 · Cited by 92 · see citing works

Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal women

Dieli-Conwright, C. M., Spektor, T. M., Rice, J. C., Sattler, F. R., & Schroeder, E. T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00590.2009 · Cited by 90 · see citing works

Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase

Lafferty, M. J., Bradford, K. C., Erie, D. A., & Neher, S. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497602 · Cited by 88 · see citing works

Nonalcoholic fatty liver disease: a challenge for pediatricians

Widhalm, K., & Ghods, E. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.185 · Cited by 85 · see citing works

Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity

Malin, S. K., del Rincon, J. P., Huang, H., & Kirwan, J. P. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000338 · Cited by 85 · see citing works

The hepatokines fetuin-A and fetuin-B are upregulated in the state of hepatic steatosis and may differently impact on glucose homeostasis in humans

Peter, A., Kovářová, M., Staiger, H., Machann, J., Schick, F., Königsrainer, A., Königsrainer, I., Schleicher, E. D., Fritsche, A., Häring, H., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2017 · Cited by 82 · see citing works

Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity

Lin, X., Braymer, H. D., Bray, G. A., & York, D. A. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00250-1 · Cited by 79 · see citing works

Activin E controls energy homeostasis in both Brown and white adipose tissues as a hepatokine

Hashimoto, O., Funaba, M., Sekiyama, K., Doi, S., Shindo, D., Satoh, R., Itoi, H., Oiwa, H., Morita, M., Suzuki, C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.008 · Cited by 77 · see citing works

A complex role of activin A in non-alcoholic fatty liver disease

Yndestad, A., Haukeland, J. W., Dahl, T. B., Bjøro, K., Gladhaug, I. P., Berge, C., Damås, J. K., Haaland, T., Løberg, E. M., Linnestad, P., et al. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.318 · Cited by 75 · see citing works

A preliminary study: Effects of football training on glucose control, body composition, and performance in men with type 2 diabetes

Andersen, T. R., Schmidt, J. F., Thomassen, M., Hornstrup, T., Frandsen, U., Randers, M. B., Hansen, P. R., Krustrup, P., & Bangsbo, J. (2014) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12259 · Cited by 74 · see citing works

Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes

Berti, L., Irmler, M., Zdichavsky, M., Meile, T., Böhm, A., Stefan, N., Fritsche, A., Beckers, J., Königsrainer, A., Häring, H.-U., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.04.002 · Cited by 73 · see citing works

A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression

Hwang, H.-J., Jung, T. W., Kim, B.-H., Hong, H. C., Seo, J. A., Kim, S. G., Kim, N. H., Choi, K. M., Choi, D. S., Baik, S. H., et al. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.08.098 · Cited by 72 · see citing works

Plasma follistatin is elevated in patients with type 2 diabetes: Relationship to hyperglycemia, hyperinsulinemia, and systemic low-grade inflammation

Hansen, J., Rinnov, A., Krogh‐Madsen, R., Fischer, C. P., Andreasen, A. S., Berg, R. M. G., Møller, K., Pedersen, B. K., & Plomgaard, P. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2415 · Cited by 71 · see citing works

Association of Fetuin-A With Incident Diabetes Mellitus in Community-Living Older Adults

Ix, J. H., Biggs, M. L., Mukamal, K. J., Kizer, J. R., Zieman, S. J., Siscovick, D. S., Mozaffarian, D., Jensen, M. K., Nelson, L., Ruderman, N. B., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.072751 · Cited by 71 · see citing works

Increased Fetuin-A Concentrations in Impaired Glucose Tolerance with or without Nonalcoholic Fatty Liver Disease, But Not Impaired Fasting Glucose

Ou, H., Yang, Y., Wu, H., Wu, J., Lu, F., & Chang, C. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2414 · Cited by 69 · see citing works

Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease

Malin, S. K., Mulya, A., Fealy, C. E., Haus, J. M., Pagadala, M. R., Scelsi, A. R., Huang, H., Flask, C. A., McCullough, A. J., & Kirwan, J. P. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00237.2013 · Cited by 68 · see citing works

Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

Ishikura, K., Misu, H., Kumazaki, M., Takayama, H., Nagata, N., Tajima, N., Chikamoto, K., Lan, F., Ando, H., Ota, T., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3306-9 · Cited by 67 · see citing works

Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins

Robciuc, M. R., Naukkarinen, J., Ortega‐Alonso, A., Tyynismaa, H., Raivio, T., Rissanen, A., Kaprio, J. A., Ehnholm, C., Jauhiainen, M., & Pietiläinen, K. H. (2011) · Journal of Lipid Research · doi:10.1194/jlr.p015867 · Cited by 67 · see citing works

Serum fetuin‐A concentrations are elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes

Ou, H., Yang, Y., Wu, H., Wu, J., Lu, F., & Chang, C. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04070.x · Cited by 66 · see citing works

High Glucose Induces Transactivation of the .ALPHA.2-HS Glycoprotein Gene Through the ERK1/2 Signaling Pathway

Takata, H., Ikeda, Y., Suehiro, T., Ishibashi, A., Inoue, M., Kumon, Y., & Terada, Y. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.no950 · Cited by 66 · see citing works

FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys

Andersen, B., Straarup, E. M., Heppner, K. M., Takahashi, D. L., Raffaele, V., Dissen, G. A., Lewandowski, K., Bödvarsdottir, T. B., Raun, K., Grove, K. L., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0080-7 · Cited by 66 · see citing works

Serum fetuin A/ α 2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis

Yilmaz, Y. N., Yönal, O., Kurt, R., Arı, F., Oral, A. Y., Çelikel, Ç., KORKMAZ, Ş., Ulukaya, E., Ozdogan, O. C., İmeryüz, N., et al. (2010) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2010.010169 · Cited by 64 · see citing works

Fetuin A promotes lipotoxicity in β cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity

Shen, X., Yang, L., Yan, S., Zheng, H., Liang, L., Cai, X., & Liao, M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.014 · Cited by 63 · see citing works

Retinol Binding Protein 4 Stimulates Hepatic Sterol Regulatory Element-Binding Protein 1 and Increases Lipogenesis Through the Peroxisome Proliferator-Activated Receptor-γ Coactivator 1β-Dependent Pathway

Xia, M., Liu, Y., Guo, H., Wang, D., Wang, Y., & Ling, W. (2013) · Hepatology · doi:10.1002/hep.26227 · Cited by 63 · see citing works

A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle

Awazawa, M., Gabel, P., Tsaousidou, E., Nolte, H., Krüger, M., Schmitz, J., Ackermann, P. J., Brandt, C., Altmuller, J., Motameny, S., et al. (2017) · Nature Medicine · doi:10.1038/nm.4420 · Cited by 63 · see citing works

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP

Ingerslev, B., Hansen, J. S., Hoffmann, C., Clemmesen, J. O., Secher, N. H., Scheler, M., Hrabĕ de Angelis, M., Häring, H. U., Pedersen, B. K., Weigert, C., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.018 · Cited by 61 · see citing works

Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease

de Oliveira, C. P. M. S., Sanches, P. D. L., de Abreu-Silva, E. O., & Marcadenti, A. (2015) · Journal of Diabetes Research · doi:10.1155/2016/4597246 · Cited by 60 · see citing works

Behavioral Treatment of the Patient with Obesity

Alamuddin, N., & Wadden, T. A. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.04.008 · Cited by 59 · see citing works

Interaction between plasma fetuin‐A and free fatty acids predicts changes in insulin sensitivity in response to long‐term exercise

Lee-Ødegård, S., Norheim, F., Gulseth, H. L., Langleite, T. M., Kolnes, K. J., Tangen, D. S., Stadheim, H. K., Gilfillan, G. D., Holen, T., Birkeland, K. I., et al. (2017) · Physiological Reports · doi:10.14814/phy2.13183 · Cited by 59 · see citing works

Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese subjects

Cullberg, K., Christiansen, T., Paulsen, S., Bruun, J., Pedersen, S., & Richelsen, B. (2013) · Obesity · doi:10.1002/oby.20060 · Cited by 58 · see citing works

The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men

Sargeant, J. A., Aithal, G. P., Takamura, T., Misu, H., Takayama, H., Douglas, J. A., Turner, M. C., Stensel, D. J., Nimmo, M. A., Webb, D. R., et al. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0639 · Cited by 56 · see citing works

Heat shock protein 72 regulates hepatic lipid accumulation

Archer, A. E., Rogers, R. S., Schulze, A. T. V., Wheatley, J. L., Morris, E. M., McCoin, C. S., Thyfault, J. P., & Geiger, P. C. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00073.2018 · Cited by 56 · see citing works

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

Takahashi, H., Kotani, K., Tanaka, K., Egucih, Y., & Anzai, K. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00588 · Cited by 55 · see citing works

Toll‐Like Receptor Expression and Response to Specific Stimulation in Adipocytes and Preadipocytes

Pietsch, J., Batra, A., STROH, T., Fedke, I., Glauben, R., Okur, B., Zeitz, M., & Siegmund, B. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.021 · Cited by 54 · see citing works

Regulation of angiopoietin-like protein 4 production during and after exercise

Norheim, F., Hjorth, M., Langleite, T. M., Lee, S., Holen, T., Bindesbøll, C., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Kielland, A., et al. (2014) · Physiological Reports · doi:10.14814/phy2.12109 · Cited by 53 · see citing works

Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction

Fletcher, J. A., Meers, G. M.-E., Laughlin, M. H., Ibdah, J. A., Thyfault, J. P., & Rector, R. S. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-091 · Cited by 53 · see citing works

Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor

Goustin, A. S., Derar, N., & Abou-Samra, A. B. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2012.12.011 · Cited by 51 · see citing works

Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals

Slusher, A. L., Whitehurst, M., Zoeller, R. F., Mock, J. T., Maharaj, M., & Huang, C.-J. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.06.002 · Cited by 50 · see citing works

Resistance training increases SHBG in overweight/obese, young men

Roberts, C. K., Croymans, D. M., Aziz, N., Butch, A. W., & Lee, C. C. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.004 · Cited by 50 · see citing works

Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A

Zhao, J., Xiong, X., Li, Y., Liu, X., Wang, T., Zhang, H., Jiao, Y., Jiang, J., Zhang, H., Tang, Q., et al. (2018) · Diabetes · doi:10.2337/db17-1348 · Cited by 47 · see citing works

A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance

Crescenzo, R., Bianco, F., Mazzoli, A., Giacco, A., Liverini, G., & Iossa, S. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1073-0 · Cited by 46 · see citing works

Acute Loading and Aging Effects on Myostatin Pathway Biomarkers in Human Skeletal Muscle After Three Sequential Bouts of Resistance Exercise

Dalbo, V. J., Roberts, M. D., Sunderland, K., Poole, C. N., Stout, J. R., Beck, T. W., Bemben, M. G., & Kerksick, C. M. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr091 · Cited by 46 · see citing works

Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding

Loyd, C., Magrisso, I. J., Haas, M., Balusu, S., Krishna, R., Itoh, N., Sandoval, D. A., Pérez–Tilve, D., Obici, S., & Habegger, K. M. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00456.2016 · Cited by 46 · see citing works

Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

Wang, Y., Liu, L.-M., Li, W., Ye, W., Meng, X., Chen, F., Xiao, Q., Chen, J.-Y., & Zhou, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5637 · Cited by 46 · see citing works

Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice

Chen, Z., Ding, L., Yang, W., Wang, J., Chen, L., Chang, Y., Geng, B., Cui, Q., Guan, Y., & Yang, J. (2017) · Diabetes · doi:10.2337/db16-0993 · Cited by 46 · see citing works

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21

Camporez, J. P., Asrih, M., Zhang, D., Kahn, M., Samuel, V. T., Jurczak, M. J., & Jornayvaz, F. R. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0136 · Cited by 44 · see citing works

Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation

Elliott, B., Herbert, P., Sculthorpe, N. F., Grace, F., Stratton, D., & Hayes, L. D. (2017) · Physiological Reports · doi:10.14814/phy2.13343 · Cited by 43 · see citing works

Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in the liver of mice is related to plasma glucose levels after acute exercise

Hoene, M., Franken, H., Fritsche, L., Lehmann, R., Pohl, A. K., Häring, H., Zell, A., Schleicher, E. D., & Weigert, C. (2010) · Diabetologia · doi:10.1007/s00125-010-1666-3 · Cited by 40 · see citing works

Cardiorespiratory Fitness and Visceral Fat Are Key Determinants of Serum Fibroblast Growth Factor 21 Concentration in Japanese Men

Taniguchi, H., Tanisawa, K., Sun, X., Cao, Z., Oshima, S., Ise, R., Sakamoto, S., & Higuchi, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1877 · Cited by 40 · see citing works

Overcoming Insulin Insufficiency by Forced Follistatin Expression in β -cells of db/db Mice

Zhao, C., Qiao, C., Tang, R., Jiang, J., Li, J., Martin, C. B., Bulaklak, K., Li, J., Wang, D. W., & Xiao, X. (2015) · Molecular Therapy · doi:10.1038/mt.2015.29 · Cited by 37 · see citing works

Activin A and follistatin in patients with nonalcoholic fatty liver disease

Pοlyzos, S. A., Kountouras, J., Anastasilakis, A. D., Triantafyllou, G. A., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.07.009 · Cited by 36 · see citing works

Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21

Porter, J. W., Rowles, J. L., Fletcher, J. A., Zidon, T. M., Winn, N. C., McCabe, L., Park, Y.-M., Perfield, J. W., Thyfault, J. P., Rector, R. S., et al. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0190 · Cited by 31 · see citing works

Elevated RBP4 plasma levels were associated with diabetic retinopathy in type 2 diabetes

Li, J., Chen, X., Lu, X.-H., Zhang, C., Shi, Q., & Feng, L. (2018) · Bioscience Reports · doi:10.1042/bsr20181100 · Cited by 31 · see citing works

Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations

Fletcher, J. A., Linden, M. A., Sheldon, R. D., Meers, G. M.-E., Morris, E. M., Butterfield, A. M., Perfield, J. W., Thyfault, J. P., & Rector, R. S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00355.2015 · Cited by 28 · see citing works

Increased Activin Bioavailability Enhances Hepatic Insulin Sensitivity While Inducing Hepatic Steatosis in Male Mice

Ungerleider, N., Bonomi, L. M., Brown, M., & Schneyer, A. L. (2013) · Endocrinology · doi:10.1210/en.2012-1844 · Cited by 27 · see citing works

Effect of physical training on liver expression of activin A and follistatin in a nonalcoholic fatty liver disease model in rats

Silva, R. N., Bueno, P. G., de Avó, L. R. D. S., Nonaka, K. O., Selistre-de-Araújo, H. S., & Leal, A. M. O. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20143869 · Cited by 24 · see citing works

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis

Chanda, D., Li, J., Oligschlaeger, Y., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Shiri‐Sverdlov, R., & Neumann, D. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.79 · Cited by 22 · see citing works

Fetuin-A and Risk of Diabetes Independent of Liver Fat Content

Aroner, S. A., Mukamal, K. J., St-Jules, D. E., Budoff, M. J., Katz, R., Criqui, M. H., Allison, M., de Boer, I. H., Siscovick, D. S., Ix, J. H., et al. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww095 · Cited by 22 · see citing works

Skeletal muscle‐specific overexpression of heat shock protein 72 improves skeletal muscle insulin‐stimulated glucose uptake but does not alter whole body metabolism

Marshall, J. P. S., Estévez, E., Kammoun, H. L., King, E. J., Bruce, C. R., Drew, B. G., Qian, H., Iliades, P., Gregorevic, P., Febbraio, M. A., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13319 · Cited by 19 · see citing works

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics

van der Kolk, B. W., Goossens, G. H., Jocken, J. W. E., Kersten, S., & Blaak, E. E. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4285 · Cited by 17 · see citing works

Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction

Hakuno, D., Kimura, M., Ito, S., Satoh, J., Nakashima, Y., Horie, T., Kuwabara, Y., Nishiga, M., Ide, Y., Baba, O., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-35194-w · Cited by 14 · see citing works

Preventive roles of swimming exercise and pioglitazone treatment on hepatic dysfunction in a rat model of metabolic syndrome

Sakr, H. F., Al-Hashem, F. H., El-Naby, W. M. H., Alkhateeb, M. A., Zaki, M. S. A., Refaey, H. E., & Morsy, M. D. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0043 · Cited by 12 · see citing works

The Effects of Aerobic Exercises and 25(OH) D Supplementation on GLP1 and DPP4 Level in Type II Diabetic Patients

Rahimi, N., Sharif, M. A. S., ., A. G., & Heidarianpour, A. (2017) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_161_17 · Cited by 8 · see citing works

AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease

Rinella, M. E., Neuschwander-Tetri, B. A., Siddiqui, M. S., Abdelmalek, M. F., Caldwell, S., Barb, D., Kleiner, D. E., & Loomba, R. (2023) · Hepatology · doi:10.1097/hep.0000000000000323 · Cited by 2,667 · see citing works

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works

Hepatokines and metabolism: Deciphering communication from the liver

Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works

Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit

McGee, S. L., & Hargreaves, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0377-1 · Cited by 221 · see citing works

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

Bourebaba, L., & Marycz, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122033 · Cited by 123 · see citing works

The metabolic basis of nonalcoholic steatohepatitis

Chakravarthy, M. V., & Neuschwander‐Tetri, B. A. (2020) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.112 · Cited by 86 · see citing works

Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases

Jouy, S. H., Mohan, S., Scichilone, G., Mostafa, A., & Mahmoud, A. M. (2024) · Biomedicines · doi:10.3390/biomedicines12092129 · Cited by 92 · see citing works

Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice

Chen, M., Zhu, J., Mu, W.-J., Luo, H.-Y., Li, Y., Li, S., Yan, L.-J., Li, R.-Y., & Guo, L. (2023) · Nature Communications · doi:10.1038/s41467-023-44242-7 · Cited by 76 · see citing works

The wonder exerkines—novel insights: a critical state-of-the-art review

Magliulo, L., Bondi, D., Pini, N., Marramiero, L., & Filippo, E. S. D. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04264-5 · Cited by 74 · see citing works

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

Kim, T. H., Hong, D.-G., & Yang, Y. M. (2021) · Biomedicines · doi:10.3390/biomedicines9121903 · Cited by 52 · see citing works

Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD)

Carneros, D., López‐Lluch, G., & Bustos, M. (2020) · Nutrients · doi:10.3390/nu12113472 · Cited by 47 · see citing works

Hepatokines as a Molecular Transducer of Exercise

Seo, D. Y., Park, S.-H., Marquez, J. C., Kwak, H., Kim, T. N., Bae, J. H., Koh, J., & Han, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030385 · Cited by 36 · see citing works

Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release

Geisler, C. E., Ghimire, S., Hepler, C., Miller, K. E., Bruggink, S. M., Kentch, K. P., Higgins, M. R., Banek, C. T., Yoshino, J., Klein, S., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109298 · Cited by 35 · see citing works

Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

Nardo, W. D., Miotto, P. M., Bayliss, J. A., Nie, S., Keenan, S. N., Montgomery, M. K., & Watt, M. J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101491 · Cited by 35 · see citing works

Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: Systematic review and meta-analysis

Khalafi, M., Alamdari, K. A., Symonds, M. E., Nobari, H., & Carlos-Vivas, J. (2021) · HORMONES · doi:10.1007/s42000-020-00245-3 · Cited by 34 · see citing works

Exercise as a tool to mitigate metabolic disease

Esteves, J. V. D. C., & Stanford, K. I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2024 · Cited by 38 · see citing works

Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis

Kim, H., Jung, J., Park, S., Joo, Y., Lee, S., Sim, J., Choi, J., Lee, H., Hwang, G., & Lee, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087284 · Cited by 26 · see citing works

Taiwan Association for the Study of the Liver-Taiwan Society of Cardiology Taiwan position statement for the management of metabolic dysfunction- associated fatty liver disease and cardiovascular diseases

Cheng, P., Chen, W., Hou, C. J., Lin, C., Chang, M., Wang, C., Chang, W., Wang, C., Lin, C., Hung, C., et al. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2023.0315 · Cited by 23 · see citing works

Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH

Henkel, J., Buchheim-Dieckow, K., Castro, J. P., Laeger, T., Wardelmann, K., Kleinridders, A., Jöhrens, K., & Püschel, G. P. (2019) · Nutrients · doi:10.3390/nu11112709 · Cited by 22 · see citing works

The endocrine role of hepatokines: implications for human health and disease

Iglesias, P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1663353 · Cited by 22 · see citing works

Crosstalk between the liver and kidney in diabetic nephropathy

Yang, M., Luo, S., Yang, J., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175219 · Cited by 17 · see citing works

Habitually inactive physically – a proposed procedure of counteracting cognitive decline in women with diminished insulin sensitivity through a high-intensity circuit training program

Micielska, K., Kortas, J. A., Gmiat, A., Jaworska, J., Flis, M., Łysak, A., Rodziewicz-Flis, E. A., Żychowska, M., & Ziemann, E. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113235 · Cited by 14 · see citing works

Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest

Ward, K., Mulder, E. R., Frings‐Meuthen, P., O’Gorman, D. J., & Cooper, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.573581 · Cited by 13 · see citing works

Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review

Hekmatikar, A. A., Nelson, A., & Petersen, A. C. (2023) · BMC Cancer · doi:10.1186/s12885-023-11391-3 · Cited by 13 · see citing works

FGF21: A Sharp Weapon in the Process of Exercise to Improve NAFLD

Wang, Z., Sun, T., Yu, J., Li, S., Gong, L., & Zhang, Y. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2812351 · Cited by 11 · see citing works

Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma

Vachher, M., Bansal, S., Kumar, B., Yadav, S., Arora, T. K., Wali, N. M., & Burman, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30252 · Cited by 11 · see citing works

Issues on Trainability

Radák, Z., & Taylor, A. W. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.790196 · Cited by 7 · see citing works

Nuclear Nicotinamide Adenine Dinucleotide Deficiency by Nmnat1 Deletion Impaired Hepatic Insulin Signaling, Mitochondrial Function, and Hepatokine Expression in Mice Fed a High-Fat Diet

Dong, H., Guo, W., Yue, R., Sun, X., & Zhou, Z. (2024) · Laboratory Investigation · doi:10.1016/j.labinv.2024.100329 · Cited by 10 · see citing works

Alterations of Serum Ser312‐Phosphorylated Fetuin‐A from Exercise‐Induced Moderate Body Weight Loss in Individuals with Obesity

Ren, G., Bowers, R. L., Kim, T., Araya-Ramírez, F., Mahurin, A. J., Dean, D. M., Grandjean, P. W., & Mathews, S. T. (2020) · Obesity · doi:10.1002/oby.22730 · Cited by 10 · see citing works

Plasma Myostatin Increases with Age in Male Youth and Negatively Correlates with Vitamin D in Severe Pediatric Obesity

Baumgartner, M., Lischka, J., Schanzer, A., de Gier, C., Walleczek, N.-K., Greber-Platzer, S., & Zeyda, M. (2022) · Nutrients · doi:10.3390/nu14102133 · Cited by 9 · see citing works

Metabolic dysfunction-associated steatotic liver disease in people with HIV

Gattu, A. K., & Fourman, L. T. (2025) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000952 · Cited by 9 · see citing works

Severe maternal stress alters placental function, resulting in adipose tissue and liver dysfunction in offspring of mice

Kondo, R., Ozawa, R., Satomi, T., Funabayashi, K., Iwata, H., Kuwayama, T., & Shirasuna, K. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111814 · Cited by 8 · see citing works

Exercise mediates myocardial infarction via non-coding RNAs

Han, C., Zhai, C., Li, A., Ma, Y., & Hallajzadeh, J. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1432468 · Cited by 7 · see citing works

Ameliorating effect of 6-week swimming exercise on mice with experimental autoimmune encephalomyelitis (EAE) by reducing fetuin-A and increasing AMPK & NAD⁺ levels in liver tissue.

Nazari, M., Kordi, M. R., Minasian, V., & Quchan, A. H. S. K. (2022) · PubMed Central · doi:10.22038/ijbms.2022.65117.14335 · Cited by 7 · see citing works

Serum selenoprotein P in lean and obese Egyptian individuals and its relation to insulin resistance

El-Kafrawy, N., Atta, A. E.-B. M., Abdelsattar, S., & Zewain, S. K. (2021) · Alexandria Journal of Medicine · doi:10.1080/20905068.2021.1876288 · Cited by 6 · see citing works

Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients

Deng, X., Cai, Z., Li, Y., Wu, X., Zhao, L., Li, H., Chen, K., Zhang, P., Wang, C., Zhao, Z., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.737624 · Cited by 6 · see citing works

Weight loss reduces intermuscular adipose tissue and liver fat compared to exercise: implications for muscle quality and metabolic health

Berry, K. A. Z., Garfield, A., Macias, E., Zarini, S., Bowen, S., Cree‐Green, M., Snell‐Bergeon, J. K., Bodkin, S. G., & Bergman, B. C. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag018 · Cited by 3 · see citing works

Fetuin-A in association with metabolic syndrome and its components

Singh, M., Sreenivasulu, K., & Choudhary, S. (2021) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20213079 · Cited by 2 · see citing works

Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver

Farsani, Z. H., Faramarzi, M., Karaji, Z. G., Akbarzadeh, H., & Hosseinzadeh, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-01156-2 · Cited by 2 · see citing works

Comparative Transcriptome Analysis Reveals the Role of the FST Gene in Goose Muscle Development

Wang, C., Liu, Y., Li, M., Yang, Y., Dai, J., Chen, S., Wang, H., & He, D. (2025) · Animals · doi:10.3390/ani15203009 · Cited by 2 · see citing works

Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers

Malaikah, S., Willis, S. A., Henson, J. J., Sargeant, J. A., Yates, T. E., Thackray, A. E., Goltz, F. R., Roberts, M. J., Bernard-Deshong, D., Aithal, G. P., et al. (2023) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2022-0445 · Cited by 1 · see citing works

High serum EDA concentration is associated with metabolic syndrome and its determinants

Deng, X., Li, Y., Gu, T., Wu, X., Sun, Z., Li, H., Yang, L., & Yuan, G. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02408-9 · Cited by 1 · see citing works

Increased Circulating Levels of EDA in Newly Diagnosed Type 2 Diabetic PatientsPreprint

Deng, X., Li, Y., Wu, X., Zhao, L., Li, H., Chen, K., Zhang, P., Zhao, Z., Qiu, Y., Yang, L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-189239/v1

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Benites-Zapata, V. A., Bohórquez-Medina, S. L., & Bohórquez-Medina, A. L. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81303-1_9-1

Markers of Liver Function and Insulin Resistance

Benites-Zapata, V. A., Bohórquez-Medina, S. L., & Bohórquez-Medina, A. L. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-08014-2_9

Investigation of cardiovascular risk parameters in adolescents with metabolic syndrome

Can, Ü., Akdu, S., Bağcı, Z., & Büyükinan, M. (2023) · Cardiology in the Young · doi:10.1017/s1047951123001622

The Effect of Sira Vedha (Phlebotomy) at Right Elbow Joint in the Management of Non-alcoholic Fatty Liver Disease - Randomized Controlled Clinical Trial

Sawarkar, G. R., Desai, P., & Sawarkar, P. G. (2023) · Journal of Natural Remedies · doi:10.18311/jnr/2023/30616

The Hepatokine Leukocyte Cell-Derived Chemotaxin-2 Is Elevated in People with Impaired Glycaemic Regulation and Augmented by Acute Exercise

Engin, B., Willis, S. A., Malaikah, S., Sargeant, J. A., Stensel, D. J., Jelleyman, C., Ennequin, G., Aithal, G. P., Yates, T. E., & King, J. A. (2024) · Livers · doi:10.3390/livers4010005

ЭПИГЕНЕТИЧЕСКИЕ ФАКТОРЫ ФОРМИРОВАНИЯ ФЕНОТИПА СОМАТИЧЕСКИХ КЛЕТОК И ПОТЕНЦИАЛА ЖИЗНЕСПОСОБНОСТИ: ТЕОРЕТИЧЕСКИЕ И ПРИКЛАДНЫЕ-АСПЕКТЫ (ОБЗОР)

Колоскова, Е. М., & Г.Г., Ч. (2025) · Problemy biologii produktivnyh životnyh · doi:10.25687/1996-6733.prodanimbiol.2025.2.5-40

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Bernard, D., Sultan, A., & Bouzakri, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178182

Physical Activity and Its Impact on Cardiometabolic Disorders

Vázquez-Jiménez, J. G., & Romero‐García, T. (2026) · Handbook of experimental pharmacology · doi:10.1007/164_2026_792

Metainflammation, Mitochondrial Dysfunction, and Organokine Crosstalk: A Central Axis Linking Metabolic Syndrome to Cardiovascular Diseases

Sodré, A. F. P., Rodrigues, L. G., Sloan, K. P., Sloan, L. A., Tanaka, M., Curi, R., Takeda, L. N., Goulart, R. D. Á., de Souza, A. L. D. M., Detregiachi, C. R. P., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156554

An in vivo resource of age-regulated C. elegans intestinal secretory-pathway proteins highlights secreted enzymes associated with lifespan regulation

Miklas, J. W., Papsdorf, K., Sun, E., Tsenter, A., Haseley, N. R., Ameglio, B., Medoh, U. N., Richard, D. J., McCarthy, F., Artiles, K. L., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117902

Hepatokines as a Molecular Transducer of Exercise

Seo, D. Y., Park, S.-H., Marquez, J. C., Kwak, H., Kim, T. N., Bae, J. H., Koh, J., & Han, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030385 · Cited by 36 · see citing works

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