Cited by 211Reproductive Biology and FertilityOvarian function and disordersHypothalamic control of reproductive hormones

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Inhibins, activins and follistatin in reproduction

de Kretser, D. M.·2002·Human Reproduction Update

DOI 10.1093/humupd/8.6.529

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Abstract

The regulation of reproductive processes involves a complex network of communication systems between the brain, endocrine organs, the gonads and other reproductive tissues. Classically, our understanding has focused on the role of endocrine hormones, but more recently interest has also dwelt on the paracrine and autocrine regulation of these cell systems. In this review, the structure and physiology of the inhibins, activins and follistatin are discussed in terms of the evidence supporting their role as endocrine hormones, and how they might function as paracrine factors within the pituitary, gonad and associated tissues. With the advent of more specific techniques and assays for their measurement, the potential of inhibins, activins and follistatin as clinical markers of reproductive function and in the screening of various pathologies is also evaluated.

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Production and actions of inhibin and activin during folliculogenesis in the rat
Findlay, J. K., Drummond, A. E., Dyson, M., et al. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00521-4 · Cited by 99
Measurement of circulating inhibin forms during the establishment of pregnancy.
Illingworth, P. J., Groome, N. P., Duncan, W. C., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636353 · Cited by 99
Analysis of the Testicular Phenotype of the Follicle-Stimulating Hormone β-Subunit Knockout and the Activin Type II Receptor Knockout Mice by Stereological Analysis*
Wreford, N. G., Kumar, T. R., Matzuk, M. M., & KRETSER, D. M. D. (2001) · Endocrinology · doi:10.1210/endo.142.7.8230 · Cited by 99
Isolation and characterization of native activin B.
Nakamura, T., Asashima, M., Eto, Y., Takio, K., Uchiyama, H., Moriya, N., Ariizumi, T., YASHIRO, T., Sugino, K., & Titani, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42014-5 · Cited by 98
Inhibin as an oocyte meiotic inhibitor
W.-S., O., Robertson, D. M., & KRETSER, D. M. D. (1989) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(89)90018-x · Cited by 98
The effect of bovine activin and follicle-stimulating hormone (FSH) suppressing protein/follistatin on FSH-induced differentiation of rat granulosa cells in vitro
Xiao, S., Findlay, J. K., & Robertson, D. M. (1990) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(90)90082-j · Cited by 97
Activin from Secondary Follicles Causes Small Preantral Follicles to Remain Dormant at the Resting Stage
Mizunuma, H., Liu, X., Andoh, K., Abe, Y., Kobayashi, J., 山田, 清., Yokota, H., Ibuki, Y., & Hasegawa, Y. (1999) · Endocrinology · doi:10.1210/endo.140.1.6409 · Cited by 97
Localization and Secretion of Inhibin/Activin Subunits in the Human and Subhuman Primate Fetal Gonads*
Rabinovici, J., Goldsmith, P. C., Roberts, V. J., et al. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1141 · Cited by 95
Maternal serum human chorionic gonadotropin level at fifteen weeks is a predictor for preeclampsia
Müller, F., Savey, L., Fiblec, B. L., et al. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70247-8 · Cited by 95
Comparison of maternal serum total activin A and inhibin A in normal, preeclamptic, and nonproteinuric gestationally hypertensive pregnancies
Silver, H. M., Lambert-Messerlian, G. M., STAR, J. A., et al. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70606-x · Cited by 94
Enhancement of primate oocyte maturation and fertilization in vitro by inhibin A and activin A
Alak, B. M., Smith, G. D., Woodruff, T. K., et al. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58583-5 · Cited by 92
Effects of FSH and IGF-I on immature rat Sertoli cells: inhibin α- and β-subunit mRNA levels and inhibin secretion
Toebosch, A., Robertson, D. M., Trapman, J., et al. (1988) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(88)90096-2 · Cited by 92
Second-trimester maternal serum inhibin A concentration as an early marker for preeclampsia
Aquilina, J. T., Barnett, A. G., Thompson, O., et al. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70448-5 · Cited by 90
Frequency Modulation of Follicle-Stimulating Hormone (FSH) during the Luteal-Follicular Transition: Evidence for FSH Control of Inhibin B in Normal Women
Welt, C. K. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2645 · Cited by 88
Immunohistochemical detection of inhibin in the gonad
Cuevas, P., Ying, S., LING, N. C., et al. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90446-3 · Cited by 87
Activin receptor mRNA expression in rat testicular cell types
de Winter, P., Themmen, A. P. N., Hoogerbrugge, J. W., et al. (1992) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(92)90201-g · Cited by 87
Maternal serum inhibin A can predict pre‐eclampsia
Cuckle, H., Sehmi, I. K., & Jones, R. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb09943.x · Cited by 87
Pituitary follistatin and inhibin subunit messenger ribonucleic acid levels are differentially regulated by local and hormonal factors
Bilezikjian, L. M., CORRIGAN, A. Z., Blount, A. L., & Vale, W. (1996) · Endocrinology · doi:10.1210/endo.137.10.8828487 · Cited by 86
Immunostainable Inhibin Subunits Are in Multiple Types of Testicular Cells*
Shaha, C., Morris, P. L., Chen, C. C., et al. (1989) · Endocrinology · doi:10.1210/endo-125-4-1941 · Cited by 86
Modulatory Actions of Activin-A and Follistatin on the Developmental Competence of In Vitro-Matured Bovine Oocytes1
Silva, C. C. G., & KNIGHT, P. G. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.2.558 · Cited by 84
Characterization and the regulation of inhibin/activin subunit proteins of cultured rat anterior pituitary cells.
Bilezikjian, L. M., Vaughan, J. M., & Vale, W. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243276 · Cited by 80
Clinical review 46: Clinical utility of inhibin measurements.
Burger, H. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.6.8501140 · Cited by 80
High Concentrations of Plasma Immunoreactive Inhibin during Normal Pregnancy in Women
Abe, Y., Hasegawa, Y., Miyamoto, K., et al. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-1-133 · Cited by 79
Expression and Localization of Activin Subunits and Follistatins in Tissues from Men with High Grade Prostate Cancer
Thomas, T. Z., Wang, H., Niclasen, P., O’Bryan, M. K., Evans, L. W., Groome, N. P., Pedersen, J., & Risbridger, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4374 · Cited by 78
Activin inhibits basal and androgen-stimulated proliferation and induces apoptosis in the human prostatic cancer cell line, LNCaP.
Wang, Q. F., Tilly, K. I., Tilly, J. L., et al. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940374 · Cited by 78
Development, validation and application of an ultra-sensitive two-site enzyme immunoassay for human follistatin
Evans, L., Muttukrishna, S., & Groome, N. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560275 · Cited by 77
Inhibin Concentrations throughout the Menstrual Cycles of Normal, Infertile, and Older Women Compared with Those during Spontaneous Conception Cycles
Lenton, E. A., de Kretser, D., WOODWARD, A. J., & ROBERTSON, M. D. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1180 · Cited by 76
Activin promotes ovarian follicle development in vitro
Li, R. (1995) · Endocrinology · doi:10.1210/en.136.3.849 · Cited by 76
Relative roles of follicle-stimulating hormone and luteinizing hormone in the control of inhibin secretion in normal men.
McLachlan, R. I., Matsumoto, A. M., Burger, H., et al. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113693 · Cited by 75
Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome
Treetampinich, C., O’Connor, A. E., MacLachlan, V. B., et al. (2000) · Human Reproduction · doi:10.1093/humrep/15.9.2028 · Cited by 75
Dimeric Inhibins in Amniotic Fluid, Maternal Serum, and Fetal Serum in Human Pregnancy1
Wallace, E. M., Riley, S. C., Crossley, J. A., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.1.3685 · Cited by 73
Activins and Inhibins in Endocrine and Other Tumors
Risbridger, G. P. (2001) · Endocrine Reviews · doi:10.1210/er.22.6.836 · Cited by 73
Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells
Bilezikjian, L. M., CORRIGAN, A. Z., Vaughan, J. M., & Vale, W. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243277 · Cited by 72
Local Regulatory Effects of Activin A and Follistatin on Meiotic Maturation of Rat Oocytes
Sadatsuki, M., Tsutsumi, O., Yamada, R., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2261 · Cited by 72
Inhibin forms in serum from postmenopausal women with ovarian cancers
Robertson, D. M., Cahir, N. F., Burger, H., et al. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00656.x · Cited by 71
Expression of Mitochondrial Heat Shock Protein 60 in Distinct Cell Types and Defined Stages of Rat Seminiferous Epithelium1
Meinhardt, A., Parvinen, M., Bacher, M., et al. (1995) · Biology of Reproduction · doi:10.1095/biolreprod52.4.798 · Cited by 70
Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145
McPherson, S. J., Thomas, T. Z., Wang, H., Gurusinghe, C. J., & Risbridger, G. P. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.1540535 · Cited by 70
Net Increase in Stimulatory Input Resulting from a Decrease in Inhibin B and an Increase in Activin A May Contribute in Part to the Rise in Follicular Phase Follicle-Stimulating Hormone of Aging Cycling Women
Reame, N. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3302 · Cited by 70
Peritubular myoid cells from immature rat testes secrete activin-A and express activin receptor type II in vitro.
de Winter, P., Vanderstichele, H., Verhoeven, G., et al. (1994) · Endocrinology · doi:10.1210/endo.135.2.8033824 · Cited by 68
Expression of inhibin/activin system messenger ribonucleic acids and proteins in ovarian follicles from women with polycystic ovarian syndrome
Roberts, V. J., Barth, S., El-Roeiy, A., & YEN, S. S. C. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962340 · Cited by 67
Circulating immunoactive inhibin in the luteal phase and early gestation of women undergoing ovulation induction
McLachlan, R. I., Healy, D. L., Robertson, D. M., et al. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59599-5 · Cited by 67
Localization of follistatin in the rat testis
Meinhardt, A., O’Bryan, M. K., McFarlane, J. R., et al. (1998) · Reproduction · doi:10.1530/jrf.0.1120233 · Cited by 66
Evaluation of maternal serum dimeric inhibin a as a first‐trimester marker of down's syndrome
Wallace, E. M., Grant, V., Swanston, I. A., et al. (1995) · Prenatal Diagnosis · doi:10.1002/pd.1970150410 · Cited by 65
A Two-Site Chemiluminescent Assay for Activin-Free Follistatin Reveals That Most Follistatin Circulating in Men and Normal Cycling Women Is in an Activin-Bound State1
McConnell, D. S., Wang, Q., Sluss, P. M., Bolf, N., Khoury, R. H., Schneyer, A. L., MIDGLEY, A. R., Reame, N. E., Crowley, W. F., & Padmanabhan, V. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4651 · Cited by 65
Overexpression of Mouse Follistatin Causes Reproductive Defects in Transgenic Mice
Guo, Q. (1997) · Molecular Endocrinology · doi:10.1210/me.12.1.96 · Cited by 65
Evidence that in a physiological setting Sertoli cell number is the major determinant of circulating concentrations of inhibin B in the adult male rhesus monkey (Macaca mulatta).
Ramaswamy, S., Marshall, G. R., McNeilly, A. S., & Plant, T. M. (1999) · PubMed · Cited by 63
Activin at parturition: changes of maternal serum levels and evidence for binding sites in placenta and fetal membranes.
Petraglia, F., Gallinelli, A., VITA, D. D., et al. (1994) · PubMed · Cited by 63
Immunohistochemical Localization of Follistatin in Rat Tissues.
Satō, K., Ogawa, K., Hayashi, Y., Nakamura, T., Titani, K., & Sugino, H. (1991) · Endocrinologia Japonica · doi:10.1507/endocrj1954.38.383 · Cited by 62
Localization of activin receptor (ActR-IIB2) mRNA in the rat seminiferous epithelium.
Kaipia, A. J., Parvinen, M., & Toppari, J. (1993) · Endocrinology · doi:10.1210/endo.132.1.8380387 · Cited by 61
Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells.
Dalkin, A. C., Gilrain, J. T., Bradshaw, D., et al. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940339 · Cited by 59
Follistatin-activin complexes in human serum and follicular fluid differ immunologically and biochemically
Schneyer, A. L., Hall, H. A., Lambert-Messerlian, G. M., Wang, Q. F., Sluss, P., & Crowley, W. F. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536619 · Cited by 59
ACTIVIN-A INHIBITS OXYTOCIN AND PROGESTERONE PRODUCTION BY PREOVULATORY BOVINE GRANULOSA CELLSIN VITRO
Shukovski, L., & Findlay, J. K. (1990) · Endocrinology · doi:10.1210/endo-126-4-2222 · Cited by 58
Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function
de Winter, P. (1993) · Endocrinology · doi:10.1210/en.132.3.975 · Cited by 58
Inhibin: a new circulating marker of hydatidiform mole?
Yohkaichiya, T., Fukaya, T., Hoshiai, H., et al. (1989) · BMJ · doi:10.1136/bmj.298.6689.1684 · Cited by 56
Elevated Levels of Maternal Serum Inhibin Immunoreactivity in Second Trimester Pregnancies Affected by Down's Syndrome
SPENCER, K. M., Wood, P. J., & Anthony, F. W. (1993) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329303000226 · Cited by 56
Testicular Expression of Inhibin and Activin Subunits and Follistatin in the Rat and Human Fetus and Neonate and During Postnatal Development in the Rat
Majdic, G. (1997) · Endocrinology · doi:10.1210/en.138.5.2136 · Cited by 56
Partial characterization of inhibin, activin, and follistatin in the term human placenta.
de Kretser, D., Foulds, L. M., Hancock, M., et al. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045969 · Cited by 55
Expression of Activin A and Follistatin Core Proteins by Human Prostate Tumor Cell Lines
McPherson, S. J., Mellor, S. L., Wang, H., et al. (1999) · Endocrinology · doi:10.1210/endo.140.11.7141 · Cited by 54
Inhibin and activin-like activity in fluids from male and female gonads: different molecular weight forms and bioactivity/immunoactivity ratios
GROOTENHUIS, A. J., Steenbergen, J., Timmerman, M. A., et al. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1220293 · Cited by 53
Maternal serum total activin A and follistatin in pregnancy and parturition
Schneider, M. E., D’Antona, D., Evans, L. W., et al. (2000) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2000.tb10402.x · Cited by 53
Interactions between activin and follicle-stimulating hormone-suppressing protein and their mechanisms of action on cultured rat granulosa cells
Xiao, S., & Findlay, J. K. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90100-7 · Cited by 52
Correlation Between Second Trimester Maternal Serum Inhibin-A and Human Chorionic Gonadotrophin for the Prediction of Pre-eclampsia
Aquilina, J., Maplethorpe, R., Ellis, P., et al. (2000) · Placenta · doi:10.1053/plac.2000.0540 · Cited by 52
Immunoradiometric assay for follistatin: serum immunoreactive follistatin levels in normal adults and pregnant women
WAKATSUKI, M., Shintani, Y., Abe, M., Liu, Z. H., Shitsukawa, K., & Saito, S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636280 · Cited by 52
Effects of activin and follicle-stimulating hormone (FSH)-suppressing protein/follistatin on FSH receptors and differentiation of cultured rat granulosa cells
Xiao, S. (1992) · Endocrinology · doi:10.1210/en.131.3.1009 · Cited by 52
Rccombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis
McLachlan, R. I., Dahl, K. D., Bremner, W. J., SCHWALL, R. H., Schmelzer, C. H., Mason, A. J., & Steiner, R. A. (1989) · Endocrinology · doi:10.1210/endo-125-5-2787 · Cited by 51
Activin maintains the condensed type of mitochondria in germ cells
Meinhardt, A., McFarlane, J. R., Seitz, J., et al. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00308-7 · Cited by 51
Male Reproductive Phenotypes in Double Mutant Mice Lacking Both FSHβ and Activin Receptor IIA
Kumar, T. R., Varani, S., Wreford, N. G., Telfer, N. M., de Kretser, D., & Matzuk, M. M. (2001) · Endocrinology · doi:10.1210/endo.142.8.8336 · Cited by 51
Developmental expression of heat shock protein 60 (HSP60) in the rat testis and ovary
Paranko, J., Seitz, J., & Meinhardt, A. (1996) · Differentiation · doi:10.1046/j.1432-0436.1996.6030159.x · Cited by 50
Follistatin concentrations in male sheep increase following sham castration/castration or injection of interleukin-1β
Phillips, D. J., Hedger, M. P., McFarlane, J. R., et al. (1996) · Journal of Endocrinology · doi:10.1677/joe.0.1510119 · Cited by 50
Abnormal concentration of maternal serum activin-A in gestational diseases
Petraglia, F. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.2.558 · Cited by 50
Inhibins, activins, and follistatins: Expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia
Thomas, T. Z., Chapman, S. M., Wang, H., Gurusingfhe, C., Mellor, S. L., Fletcher, R. J., Pedersen, J., & Risbridger, G. P. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19980101)34:1 · Cited by 49
Biological and immunological characterization of inhibin forms in human plasma
Robertson, D. M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.2.669 · Cited by 47
Human recombinant activin-A alters pituitary luteinizing hormone and follicle-stimulating hormone secretion, follicular development, and steroidogenesis, during the menstrual cycle in rhesus monkeys.
Stouffer, R. L., Woodruff, T. K., Dahl, K. D., et al. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.1.8325947 · Cited by 46
Age-dependent activin receptor expression pinpoints activin A as a physiological regulator of rat Sertoli cell proliferation
Fragale, A. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.12.1107 · Cited by 46
Feto-Placental Hypoxemia Regulates the Release of Fetal Activin A and Prostaglandin E2
Jenkin, G., Ward, J. W., Hooper, S. B., et al. (2001) · Endocrinology · doi:10.1210/endo.142.2.8110 · Cited by 46
A Two-Site Chemiluminescent Assay for Activin-Free Follistatin Reveals That Most Follistatin Circulating in Men and Normal Cycling Women Is in an Activin-Bound State
McConnell, D. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.851 · Cited by 46
The Source of Inhibin Secretion during the Human Menstrual Cycle*
Illingworth, P. J., Reddi, K., Smith, K. B., et al. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-3-667 · Cited by 44
Measurement of circulating inhibin forms during the establishment of pregnancy
Illingworth, P. J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.4.1471 · Cited by 44
Effect of inhibin immunoneutralization on steroidogenesis in rat ovarian follicles in vitro
Smyth, C. D., Gosden, R. G., McNeilly, A. S., et al. (1994) · Journal of Endocrinology · doi:10.1677/joe.0.1400437 · Cited by 43
Maternal serum inhibin levels in second‐trimester down's syndrome pregnancies
Cuckle, H., Holding, S., & Jones, R. (1994) · Prenatal Diagnosis · doi:10.1002/pd.1970140508 · Cited by 42
Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium
Kaipia, A. J. (1992) · Endocrinology · doi:10.1210/en.131.6.2703 · Cited by 42
Measurement of activin in biological fluids by radioimmunoassay, utilizing dissociating agents to remove the interference of follistatin
McFarlane, J. R., Foulds, L. M., Pisciotta, A., et al. (1996) · European Journal of Endocrinology · doi:10.1530/eje.0.1340481 · Cited by 41
Follistatin and activin A production by the male reproductive tract
Anderson, R. A., Evans, L. W., Irvine, D. S., et al. (1998) · Human Reproduction · doi:10.1093/humrep/13.12.3319 · Cited by 41
Changes of Dimeric Inhibin B Levels in Maternal Serum Throughout Healthy Gestation and in Women with Gestational Diseases1
Petraglia, F., Luisi, S. V., Benedetto, C., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4241 · Cited by 40
Identification of activins and follistatin proteins in human follicular fluid and placenta.
Yokoyama, Y., Nakamura, T., Nakamura, R., et al. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7883850 · Cited by 40
Differential regulation of inhibin/activin α- and βA-subunit and follistatin mRNAs by cyclic AMP and phorbol ester in cultured human granulosa-luteal cells
Tuuri, T., ERÄMAA, M., van Schaik, R. H. N., et al. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(96)03842-7 · Cited by 39
Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function.
de Winter, J. P., Vanderstichele, H. M., Timmerman, M. A., et al. (1993) · Endocrinology · doi:10.1210/endo.132.3.7679985 · Cited by 39
Clinical review 46: Clinical utility of inhibin measurements
Burger, H. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.76.6.1391 · Cited by 39
Differential Localization of Inhibin Subunit Proteins in the Ovine Testis during Fetal Gonadal Development*
Jarred, R. A., Cancilla, B., Richards, M. G., et al. (1999) · Endocrinology · doi:10.1210/endo.140.2.6471 · Cited by 38
Human Recombinant Inhibin a Suppresses Plasma Follicle-Stimulating Hormone to Intact Levels but has No Effect on Luteinizing Hormone in Castrated Rams1
Tilbrook, A. J., KRETSER, D. M. D., & Clarke, I. J. (1993) · Biology of Reproduction · doi:10.1095/biolreprod49.4.779 · Cited by 38
Inhibin B plasma concentrations in oligozoospermic subjects before and after therapy with follicle stimulating hormone
Foresta, C. (1999) · Human Reproduction · doi:10.1093/humrep/14.4.906 · Cited by 37
Inhibin in extra-embryonic coelomic and amniotic fluids and maternal serum in early pregnancy
Riley, S. C., Wathen, N. C., Chard, T., et al. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019208 · Cited by 36
Measurement of inhibin concentrations in men: study of changes after castration and comparison with androgen levels in testicular tissue, spermatic venous blood, and peripheral venous blood
ISHIDA, H., TASHIRO, H., WATANABE, M., FUJII, N., IMAMURA, K., MINOWADA, S., SHINOHARA, M., FUKUTANI, K., ASO, Y., & DE KRETSER, D. M. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-4-1019 · Cited by 35
Self-citation
Male Sterility in Transgenic Mice Expressing Activin βA Subunit Gene in Testis
Tanimoto, Y., Tanimoto, K., Sugiyama, F., Horiguchi, H., Murakami, K., Yagami, K., & Fukamizu, A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0833 · Cited by 35
Differential patterns of inhibin secretion in response to gonadotrophin stimulation in normal men
Kinniburgh, D. W., & Anderson, R. A. (2001) · International Journal of Andrology · doi:10.1046/j.1365-2605.2001.00276.x · Cited by 34
Changes of Dimeric Inhibin B Levels in Maternal Serum Throughout Healthy Gestation and in Women with Gestational Diseases
Petraglia, F. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.9.2991 · Cited by 34
Inhibin-related proteins in rat prostate
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Authors: de Kretser, D. M.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 2002-11-01
Volume: 8
Issue: 6
Pages: 529-541
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/8.6.529
OpenAlex: W2166390226
Cited by: 211
References: 223
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 3 · 2013: 12 · 2012: 13
FWCI: 1.22
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction Update (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: inhibin, activin, follistatin, reproductive control, paracrine signaling, autocrine regulation, endocrine hormones, pituitary gland, gonads
MeSH terms: Animals, Female, Follicle Stimulating Hormone, Humans, Inhibins, Male, Ovary, Pregnancy, Reproduction, Testis, Activins, Follistatin

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Inhibins, activins and follistatin in reproduction

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