The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
Endometrial receptivity markers, the journey to successful embryo implantation.
Abstract
Human embryo implantation is a three-stage process (apposition, adhesion and invasion) involving synchronized crosstalk between a receptive endometrium and a functional blastocyst. This ovarian steroid-dependent phenomenon can only take place during the window of implantation, a self-limited period of endometrial receptivity spanning between days 20 and 24 of the menstrual cycle. Implantation involves a complex sequence of signalling events, consisting in the acquisition of adhesion ligands together with the loss of inhibitory components, which are crucial to the establishment of pregnancy. Histological evaluation, now considered to add little clinically significant information, should be replaced by functional assessment of endometrial receptivity. A large number of molecular mediators have been identified to date, including adhesion molecules, cytokines, growth factors, lipids and others. Thus, endometrial biopsy samples can be used to identify molecules associated with uterine receptivity to obtain a better insight into human implantation. In addition, development of functional in vitro systems to study embryo-uterine interactions will lead to better definition of the interactions existing between the molecules involved in this process. The purpose of this review was not only to describe the different players of the implantation process but also to try to portray the relationship between these factors and their timing in the process of uterine receptivity.
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“Embryo implantation is a pivotal step during pregnancy and the failure of the embryo to implant into the uterine endometrium at early pregnancy stages is a major cause of infertility [45].”
From Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation (2010) · cites this paper as [45]
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Cites
Items 201–209 of 209
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Cited by
Sorted by citations
The role of infection in miscarriage
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E. M., & Horne, A. W. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv041 · Cited by 464
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BackgroundMicroRNA signature and regulatory functions in the endometrium during normal and disease states
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Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects
Lessey, B., Lebovic, D., & Taylor, R. (2013) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1333476 · Cited by 113
The roles of leptin and adiponectin at the fetal-maternal interface in humans
Dos Santos, E., Duval, F., Vialard, F., & Dieudonné, M.-N. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0031 · Cited by 52
Metadata
- Authors
- Achache, H., & Revel, A.
- Affiliations
- Hadassah Medical Center (IL)
- Corresponding author
- Achache, Hanna
- ORCID
- Revel, Ariel
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-18
- Volume
- 12
- Issue
- 6
- Pages
- 731-746
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2130463115
- Cited by
- 952
- References
- 209
- Citations by year
- 2026: 55 · 2025: 73 · 2024: 50 · 2023: 72 · 2022: 80 · 2021: 73 · 2020: 85 · 2019: 61 · 2018: 40 · 2017: 47 · 2016: 45 · 2015: 39 · 2014: 37 · 2013: 36 · 2012: 36
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- endometrial receptivity, embryo implantation, blastocyst adhesion, embryo-uterus interaction, implantation window, endometrial biopsy, adhesion molecules, cytokines, growth factors, lipids, implantation failure
- MeSH terms
- Animals, Endometrium, Female, Humans, Infertility, Female, Embryo Implantation, Pregnancy, Prostaglandins, Biomarkers, Cell Adhesion Molecules, Cytokines
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