Cited by 52Reproductive System and PregnancyPregnancy and preeclampsia studiesAdipokines, Inflammation, and Metabolic Diseases

The roles of leptin and adiponectin at the fetal-maternal interface in humans

Dos Santos, Esther, Duval, Fabien, Vialard, François, Dieudonné, Marie-Noëlle·2015·Hormone Molecular Biology and Clinical Investigation

Abstract

Infertility now affects one in seven couples, and the prevalence of this condition continues to increase. Ovulatory defects and unknown causes account for more than half of the cases of infertility. It has been postulated that a significant proportion of these cases are directly or indirectly related to obesity, since the presence of excess adipose tissue has a variety of effects on reproductive function. Here, we review on the effects of the two major adipokines (leptin and adiponectin) on fertility, with a focus on the first steps in embryo implantation and the key components of fetal-maternal interface (the placenta and the endometrium). These adipokines are reportedly involved in the regulation of cell proliferation and differentiation, and as such affect local angiogenesis, immune tolerance and inflammatory processes in placental and endometrial tissues. In placental cells, leptin and adiponectin also modulate trophoblast invasiveness and the nutrient supply. These observations strongly suggest by interfering with the placenta and endometrium, adipokines can create a favorable environment for embryo implantation and have a key role in fetal-maternal metabolism, fetal-maternal communication, and gestation. Given that reproductive functions are tightly coupled to the energy balance, metabolic abnormalities may lead to the development of complications of pregnancy and changes in fetal growth. In this context, we suggest that the leptin/adiponectin ratio may be a clinically valuable marker for detecting a number of pathologies in pregnancy.

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Crossref · 10.1515/hmbci-2015-0031

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Authors
Dos Santos, E., Duval, F., Vialard, F., & Dieudonné, M.-N.
Affiliations
Université de Versailles Saint-Quentin-en-Yvelines (FR)
Venue
Hormone Molecular Biology and Clinical Investigation
Published
2015-10-01
Volume
24
Issue
1
Pages
47-63
ISSN
  • 1868-1883 (ISSN-L)
  • 1868-1891
OpenAlex
W1874108458
Cited by
52
References
158
Citations by year
2026: 2 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 1 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 5
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone Molecular Biology and Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
leptin, adiponectin, adipokines, maternal-fetal interface, embryo implantation, placenta, endometrium, infertility, obesity, trophoblast invasion, angiogenesis, immune tolerance, inflammation, fetal growth, leptin/adiponectin ratio, pregnancy complications, energy balance
MeSH terms
Endometrium, Female, Humans, Maternal-Fetal Exchange, Obesity, Embryo Implantation, Placenta, Pregnancy, Pregnancy Complications, Leptin, Fetal Development, Adiponectin

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