The roles of leptin and adiponectin at the fetal-maternal interface in humans
Abstract
Infertility now affects one in seven couples, and the prevalence of this condition continues to increase. Ovulatory defects and unknown causes account for more than half of the cases of infertility. It has been postulated that a significant proportion of these cases are directly or indirectly related to obesity, since the presence of excess adipose tissue has a variety of effects on reproductive function. Here, we review on the effects of the two major adipokines (leptin and adiponectin) on fertility, with a focus on the first steps in embryo implantation and the key components of fetal-maternal interface (the placenta and the endometrium). These adipokines are reportedly involved in the regulation of cell proliferation and differentiation, and as such affect local angiogenesis, immune tolerance and inflammatory processes in placental and endometrial tissues. In placental cells, leptin and adiponectin also modulate trophoblast invasiveness and the nutrient supply. These observations strongly suggest by interfering with the placenta and endometrium, adipokines can create a favorable environment for embryo implantation and have a key role in fetal-maternal metabolism, fetal-maternal communication, and gestation. Given that reproductive functions are tightly coupled to the energy balance, metabolic abnormalities may lead to the development of complications of pregnancy and changes in fetal growth. In this context, we suggest that the leptin/adiponectin ratio may be a clinically valuable marker for detecting a number of pathologies in pregnancy.
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Low concentrations of leptin and leptin resistance may play a role in miscarriage because leptin has a role in embryonic implantation and establishment of the placenta.
“Both low concentrations of leptin and leptin resistance may play a role in miscarriage because this hormone has a role in embryonic implantation and the establishment of the placenta. 36”
From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [36]
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Thyroid Hormones in Early Pregnancy and Birth Weight: A Retrospective Study
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- Authors
- Dos Santos, E., Duval, F., Vialard, F., & Dieudonné, M.-N.
- Affiliations
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Venue
- Hormone Molecular Biology and Clinical Investigation
- Publisher
- Walter de Gruyter GmbH
- Published
- 2015-10-01
- Volume
- 24
- Issue
- 1
- Pages
- 47-63
- ISSN
- 1868-1883 (ISSN-L)
- 1868-1891
- OpenAlex
- W1874108458
- Cited by
- 52
- References
- 158
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 1 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 5
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Molecular Biology and Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leptin, adiponectin, adipokines, maternal-fetal interface, embryo implantation, placenta, endometrium, infertility, obesity, trophoblast invasion, angiogenesis, immune tolerance, inflammation, fetal growth, leptin/adiponectin ratio, pregnancy complications, energy balance
- MeSH terms
- Endometrium, Female, Humans, Maternal-Fetal Exchange, Obesity, Embryo Implantation, Placenta, Pregnancy, Pregnancy Complications, Leptin, Fetal Development, Adiponectin
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