Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects
Abstract
The endometrium is ground zero when it comes to understanding how implantation occurs and how it might also fail, resulting in infertility or pregnancy loss. Many of the causes of diminished uterine receptivity are acquired during a woman's lifetime. Endometriosis, a major inflammatory disease affecting women, is also a leading cause of infertility and miscarriage. Once established, the inflammatory changes can, in some women, lead to progesterone resistance and downstream changes in endometrial gene expression. Much is now known about how inflammation translates to progesterone resistance and infertility, but much remains to be learned. In this review we provide an overview for understanding how the endometrium becomes dysfunctional, what biomarkers may hold promise for the diagnosis of endometriosis, and how progesterone resistance leads to infertility. Understanding the pathophysiology of this disease will likely lead to better treatment options.
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In the endometrium of women with endometriosis, several hundred minor biochemical changes have been described.
“In the endometrium of women with endometriosis several hundred minor biochemical changes have been described (124-128).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [125]
More than 200 differences between the endometrium of women with and without endometriosis have been described.
“More than 200 differences between the endometrium of women with and without endometriosis were described (for recent reviews, see Refs.[169][170][171][172][173]).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [170]
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Self-citationSundqvist, J., Andersson, K. L., Scarselli, G. F., Gemzell‐Danielsson, K., & Lalitkumar, P. G. (2012) · Human Reproduction · doi:10.1093/humrep/des220 · Cited by 60 · see citing works
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Zondervan, K. T., Becker, C. M., Koga, K., Missmer, S. A., Taylor, R. N., & Viganò, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0008-5 · Cited by 1,257 · see citing works
Self-citationEndometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options
Tanbo, T., & Fedorcsak, P. (2017) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.13082 · Cited by 432 · see citing works
Pathogenesis of endometriosis: The genetic/epigenetic theory
Koninckx, P. R., Ussia, A., Adamyan, L., Wattiez, A., Gomel, V., & Martin, D. C. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.013 · Cited by 427 · see citing works
Progesterone resistance in endometriosis: origins, consequences and interventions
Patel, B. G., Rudnicki, M., Yu, J., Shu, Y., & Taylor, R. N. (2017) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13156 · Cited by 336 · see citing works
Self-citationLessey, B. A., & Kim, J. J. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.031 · Cited by 286 · see citing works
Self-citationPathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241 · see citing works
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“…regulation over endometrial invasion, as well as up- regulated angiogenesis, pro- inflammatory cytokine expression, and oxidative stress (Brosens et al., 2012; Gellersen & Brosens, 2014; Lessey et al., 2013; Matteo et al., 2017; Sharpe- Timms, 2001; Soares et al., 2012; Xavier et al., 2005).”
BackgroundRetinoic Acid Biosynthesis Is Impaired in Human and Murine Endometriosis1
Pierzchalski, K., Taylor, R. N., Nezhat, C., Jones, J. W., Napoli, J. L., Yang, G., Kane, M. A., & Sidell, N. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.119677 · Cited by 50 · see citing works
Self-citationThe known, the unknown and the future of the pathophysiology of endometriosis
Ochoa Bernal, M. A., & Fazleabas, A. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115815 · Cited by 59 · see citing works
“Women with endometriosis have a higher risk of infertility and miscarriage, due in part to endometrial abnormalities [131].”
BackgroundBCL-6 Overexpression as a predictor for endometriosis in patients undergoing in vitro fertilization
Nezhat, C., Rambhatla, A., Miranda-Silva, C., Asiaii, A., Nguyen, K., Eyvazzadeh, A., Tazuke, S., Agarwal, S., Jun, S., Nezhat, A., et al. (2020) · JSLS : Journal of the Society of Laparoscopic & Robotic Surgeons · doi:10.4293/jsls.2020.00064 · Cited by 34 · see citing works
- Authors
- Lessey, B., Lebovic, D., & Taylor, R.
- Affiliations
- Prisma Health (US)
- University of Wisconsin System (US)
- Wake Forest University Health Sciences (US)
- Venue
- Seminars in Reproductive Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2013-02-27
- Volume
- 31
- Issue
- 02
- Pages
- 109-124
- ISSN
- 1526-4564 (ISSN-L)
- 1526-8004
- OpenAlex
- W1984413516
- Cited by
- 113
- References
- 252
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 8 · 2023: 8 · 2022: 13 · 2021: 9 · 2020: 13 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 11 · 2015: 15 · 2014: 7 · 2013: 2
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Reproductive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD067721)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometriosis, endometrium, implantation defects, endometrial receptivity, progesterone resistance, infertility, miscarriage, endometritis, endometrial gene expression, endometriosis diagnosis
- MeSH terms
- Animals, Endometriosis, Endometrium, Female, Humans, Infertility, Female, Embryo Implantation, Pregnancy, Pregnancy Maintenance, Progesterone, Biomarkers, Chemokines, Embryo Loss
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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