Cited by 113Endometriosis Research and TreatmentReproductive System and PregnancyReproductive Biology and Fertility

Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects

Lessey, Bruce, Lebovic, Dan, Taylor, Robert·2013·Seminars in Reproductive Medicine

Abstract

The endometrium is ground zero when it comes to understanding how implantation occurs and how it might also fail, resulting in infertility or pregnancy loss. Many of the causes of diminished uterine receptivity are acquired during a woman's lifetime. Endometriosis, a major inflammatory disease affecting women, is also a leading cause of infertility and miscarriage. Once established, the inflammatory changes can, in some women, lead to progesterone resistance and downstream changes in endometrial gene expression. Much is now known about how inflammation translates to progesterone resistance and infertility, but much remains to be learned. In this review we provide an overview for understanding how the endometrium becomes dysfunctional, what biomarkers may hold promise for the diagnosis of endometriosis, and how progesterone resistance leads to infertility. Understanding the pathophysiology of this disease will likely lead to better treatment options.

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Registry

Crossref · 10.1055/s-0032-1333476

Cites

252 of 252 references verified0 citation errors · 0 not checkable

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  • In the endometrium of women with endometriosis, several hundred minor biochemical changes have been described.

    “In the endometrium of women with endometriosis several hundred minor biochemical changes have been described (124-128).”

    From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [125]

  • More than 200 differences between the endometrium of women with and without endometriosis have been described.

    “More than 200 differences between the endometrium of women with and without endometriosis were described (for recent reviews, see Refs.[169][170][171][172][173]).”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [170]

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Authors
Lessey, B., Lebovic, D., & Taylor, R.
Affiliations
  • Prisma Health (US)
  • University of Wisconsin System (US)
  • Wake Forest University Health Sciences (US)
Venue
Seminars in Reproductive Medicine
Published
2013-02-27
Volume
31
Issue
02
Pages
109-124
ISSN
  • 1526-4564 (ISSN-L)
  • 1526-8004
OpenAlex
W1984413516
Cited by
113
References
252
Citations by year
2026: 4 · 2025: 2 · 2024: 8 · 2023: 8 · 2022: 13 · 2021: 9 · 2020: 13 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 11 · 2015: 15 · 2014: 7 · 2013: 2
FWCI
14.09
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Reproductive Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD067721)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
endometriosis, endometrium, implantation defects, endometrial receptivity, progesterone resistance, infertility, miscarriage, endometritis, endometrial gene expression, endometriosis diagnosis
MeSH terms
Animals, Endometriosis, Endometrium, Female, Humans, Infertility, Female, Embryo Implantation, Pregnancy, Pregnancy Maintenance, Progesterone, Biomarkers, Chemokines, Embryo Loss

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