CoChat
Sign Up
Cited by 852Ovarian function and disordersGestational Diabetes Research and ManagementAssisted Reproductive Technology and Twin Pregnancy

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome

Boomsma, C.M., Eijkemans, M.J.C., Hughes, E.G., Visser, G.H.A., Fauser, B.C.J.M., Macklon, N.S.·2006·Human Reproduction Update
DOI 10.1093/humupd/dml036
Open this paper in CoChat — free account

Abstract

Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with many characteristic features, including hyperandrogenaemia, insulin resistance and obesity which may have significant implications for pregnancy outcomes and long-term health of the woman. This meta-analysis was conducted to evaluate the risk of pregnancy and neonatal complications in women with PCOS. Electronic databases were searched for the following MeSH headings: PCOS, hyperandrogenism, pregnancy outcome, pregnancy complications, diabetes mellitus, type II. A handsearch of human reproduction and fertility and sterility was also conducted. Studies in which pregnancy outcomes in women with PCOS were compared with controls were considered for inclusion in this meta-analysis. Fifteen of 525 identified studies were included, involving 720 women presenting with PCOS and 4505 controls. Women with PCOS demonstrated a significantly higher risk of developing gestational diabetes [odds ratio (OR) 2.94; 95% confidence interval (CI): 1.70–5.08], pregnancy-induced hypertension (OR 3.67; 95% CI: 1.98–6.81), pre-eclampsia (OR 3.47; 95% CI: 1.95–6.17) and preterm birth (OR 1.75; 95% CI: 1.16–2.62). Their babies had a significantly higher risk of admission to a neonatal intensive care unit (OR 2.31; 95% CI: 1.25–4.26) and a higher perinatal mortality (OR 3.07; 95% CI: 1.03–9.21), unrelated to multiple births. In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications. Pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks.

Overview

Integrity signals

Registry

Crossref · 10.1093/humupd/dml036

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 42 references

Research works printed but not linked: 10

  1. Franks, 2001, N Engl J Med, 333, 853, 10.1056/NEJM199509283331307 · DOI · Paper page
  2. Haslam, 2005, The Lancet, 366, 1197, 10.1016/S0140-6736(05)67483-1 · DOI · Paper page
  3. Kashyap, 2000, J Reprod Med, 45, 991
  4. Levran, 1990, Int J Fertil, 35, 157
  5. Radon, 1999, Obstet Gynecol, 94, 194
  6. Scholten, 1999, Ned Tijdschr Geneeskd, 143, 843
  7. 2004, Fertil Steril, 81, 19
  8. 2004, Hum Reprod, 19, 41, 10.1093/humrep/deh098 · DOI · Paper page
  9. Urman, 1997, J Reprod Med, 42, 501
  10. Wortsman, 1991, J Reprod Med, 36, 659

Cited by

Sorted by citations

Items 501–600 of 850

Related

See all

Metadata

Authors
Boomsma, C. M., Eijkemans, M. J. C., Hughes, E. G., Visser, G. H. A., Fauser, B. C. J. M., & Macklon, N. S.
Affiliations
  • University Medical Center Utrecht (NL)
  • Erasmus University Rotterdam (NL)
  • McMaster University (CA)
  • Utrecht University (NL)
Corresponding author
Boomsma, C.M.
ORCID
Venue
Human Reproduction Update
Publisher
Oxford University Press (OUP)
Published
2006-08-04
Volume
12
Issue
6
Pages
673-683
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
DOI
10.1093/humupd/dml036
OpenAlex
W2101687529
Cited by
852
References
42
Citations by year
2026: 26 · 2025: 29 · 2024: 58 · 2023: 55 · 2022: 59 · 2021: 37 · 2020: 53 · 2019: 52 · 2018: 38 · 2017: 44 · 2016: 40 · 2015: 51 · 2014: 61 · 2013: 41 · 2012: 39
FWCI
4.80
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords
polycystic ovary syndrome, pregnancy outcomes, gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, neonatal intensive care admission, perinatal mortality, hyperandrogenemia, insulin resistance, obesity
MeSH terms
Birth Weight, Cesarean Section, Female, Humans, Infant Mortality, Infant, Newborn, Infertility, Female, Polycystic Ovary Syndrome, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Diabetes, Gestational, Hypertension, Pregnancy-Induced, Premature Birth

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review