Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis
Open accessAbstract
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined. Methods: Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University. Results: A total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49–4.74), PIH (OR3.43; 95% CI: 2.49–4.74), preeclampsia (OR2.17; 95% CI: 1.91–2.46), preterm birth (OR1.93; 95%CI: 1.45–2.57), caesarean section (OR 1.74; 95% CI: 1.38–2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD −0.11g; 95%CI: -0.19 – -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40–3.85) compared to controls. Conclusions: Women with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications.
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Women with PCOS have 2.8 to 4.3 times the risk of developing gestational diabetes mellitus during pregnancy compared to women without PCOS.
“Women with PCOS have 2.8 to 4.3 times the risk of developing GDM during pregnancy, compared to women without PCOS [53–55].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [55]
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- Authors
- Qin, J. Z., Pang, L. H., Li, M. J., Fan, X. J., Huang, R. D., & Chen, H. Y.
- Affiliations
- First Affiliated Hospital of GuangXi Medical University (CN)
- Corresponding author
- Pang, Li H
- Li, Mu J
- Venue
- Reproductive Biology and Endocrinology
- Published
- 2013-06-26
- Volume
- 11
- Issue
- 1
- Pages
- 56-56
- ISSN
- 1477-7827 (ISSN-L)
- PMC
- PMC3737012
- OpenAlex
- W2143450042
- Cited by
- 317
- References
- 49
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 41 · 2023: 27 · 2022: 38 · 2021: 27 · 2020: 27 · 2019: 25 · 2018: 27 · 2017: 18 · 2016: 9 · 2015: 28 · 2014: 17
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Reproductive Biology and Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- polycystic ovary syndrome, pregnancy complications, gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, cesarean section, birth weight, neonatal intensive care admission, adverse pregnancy outcomes
- MeSH terms
- Female, Humans, Infant, Newborn, Polycystic Ovary Syndrome, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Diabetes, Gestational, Risk Assessment, Hypertension, Pregnancy-Induced, Premature Birth
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